In vitro anti-Leishmania activity of new isomeric cobalt(II)complexes and in silico insights: Mitochondria impairment and apoptosis-like cell death of the parasite

Rocha, Samuel M.; Horn, Adolfo; Aline, R. de M.L. Terra; Rezende, Lara M.; Moreira, Felipe F.; DaMatta, Renato Augusto; Xavier, Fernando R.; Cervo, Rodrigo; Cargnelutti, Roberta; Moorkkannur, Sreerag N.; Owenby, Graysen; Prabhakar, Rajeev; Seabra, Sérgio Henrique; Fernandes, Christiane

doi:10.1016/j.jinorgbio.2022.112088

Cited by 4 publications

(1 citation statement)

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“…Only a few Cu(II) complexes with considerable anti-Toxoplasma activity were described, while no Co(II) complexes have been published until now showing activity against T. gondii parasites [44]. Antileishmanial Co(II) complexes with comparable activities were recently disclosed, and their mechanism of action involved mitochondrial damage associated with the induction of apoptosis-like parasite death [45]. Both Cu(II) and Co(II) complexes were also reported to target DNA, while Co(II) salts such as CoCl 2 are well-established hypoxia inducers [46][47][48].…”

Section: Discussionmentioning

confidence: 99%

Old Dogs with New Tricks: Antiparasitic Potential of Structurally Diverse 5-Nitrofuran and 5-Nitrothiophene Imines and Acyl Hydrazones

Al Nasr,

Koko,

Khan

et al. 2023

Sci. Pharm.

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Miscellaneous imines and acyl hydrazones were prepared from 5-nitrofuraldehyde and 5-nitrothiophene-2-carboxaldehyde. Their activities against Toxoplasma gondii and Leishmania major parasites were evaluated. Promising antiparasitic effects and selectivities were observed for certain acyl hydrazones and imines. Cobalt(II) and copper(II) complexes conserved the high anti-Toxoplasma activities of 3-hydroxy-2-naphthoic carboxyl hydrazone (2a). In addition, sound activities against L. major promastigotes were observed for various analogs of 2a (2b and 2i) and pyrid-2-ylpyrazole-based imines (3g and 3h). Relatively low toxicities to kidney cells and macrophages indicate promising selectivity profiles for these compounds.

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