In vitro anti-Leishmania infantum activity of essential oil from Piper angustifolium

Bosquiroli, Lauriane S. S.; Demarque, Daniel P.; Rizk, Yasmin Silva; Cunha, Marillin C.; Marques, Maria Carolina Silva; Matos, Maria de Fátima Cepa; Toffoli-Kadri, Mônica Cristina; Carollo, Carlos Alexandre; Arruda, Carla Cardozo Pinto de

doi:10.1016/j.bjp.2015.03.008

Cited by 32 publications

(21 citation statements)

References 32 publications

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“…C. verum extracts contain a mixture of polyphenols with cinnamaldehyde that plays a significant therapeutic role in cancer cell lines by depolarization of the mitochondrial membrane potential, leading to cellular apoptosis without cytotoxic activities on host cells [32]. One possible explanation of the modest selectivity index of AECV and EAECV is due to the presence of alkaloids and terpenoids [30,33]. The aforementioned results indicating the safety of C. verum extracts for the treatment of animals and humans following further clinical studies.…”

Section: Discussionmentioning

confidence: 90%

“…For example, von Son-de Fernex et al [27] and Williams et al [28] documented the in vitro anthelmintic activity of 2H-chromen-2-one and cinnamaldehyde, the main chemical component in AECV and EAECV against Cooperia Punctata and the swine nematode Ascaris suum, whereas Kpadonou et al [29] disclosed the antitrypanosomal efficacy of caryophyllene oxide against Trypanosoma brucei brucei with IC 50 value of 17.67 µg/mL. Moreover, Bosquiroli et al [30] proved antileishmanial activity of caryophyllene and caryophyllene oxide against promastigotes of L. infantum. In addition to that, Le et al [31] reported the anti-protozoal activity of C. verum essential oil and its constituents (cinnamaldehyde and caryophyllene) against Leishmania, Plasmodium and Trypanosoma.…”

Section: Discussionmentioning

confidence: 99%

“…The combination therapies of AECV and EAECV with DA were evaluated using the fluorescence assay in the in vitro culture of B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi as reported previously elsewhere [30]. Briefly, two-drug combinations of AECV and EAECV with DA, MESA and MEOE at five selected concentrations 0.25 ×, 0.5 ×, 1 ×, 2 ×, and 4 × the IC 50 were added in 96 well-plates in duplicate.…”

Section: In Vitro Drug Combination Testmentioning

confidence: 99%

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Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo

et al. 2020

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Cinnamomum verum is a commonly used herbal plant that has several documented properties against various diseases. The existing study evaluated the inhibitory effect of acetonic extract of C. verum (AECV) and ethyl acetate extract of C. verum (EAECV) against piroplasm parasites in vitro and in vivo. The drug-exposure viability assay was tested on Madin-Darby bovine kidney (MDBK), mouse embryonic fibroblast (NIH/3T3) and human foreskin fibroblast (HFF) cells. Qualitative phytochemical estimation revealed that AECV and EAECV containing multiple bioactive constituents namely alkaloids, tannins, saponins, terpenoids and remarkable amounts of polyphenols and flavonoids. AECV and EAECV inhibited B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi multiplication at half-maximal inhibitory concentrations (IC50) of 23.1 ± 1.4, 56.6 ± 9.1, 33.4 ± 2.1, 40.3 ± 7.5, 18.8 ± 1.6 µg/mL, and 40.1 ± 8.5, 55.6 ± 1.1, 45.7 ± 1.9, 50.2 ± 6.2, and 61.5 ± 5.2 µg/mL, respectively. In the cytotoxicity assay, AECV and EAECV affected the viability of MDBK, NIH/3T3 and HFF cells with half-maximum effective concentrations (EC50) of 440 ± 10.6, 816 ± 12.7 and 914 ± 12.2 µg/mL and 376 ± 11.2, 610 ± 7.7 and 790 ± 12.4 µg/mL, respectively. The in vivo experiment showed that AECV and EAECV were effective against B. microti in mice at 150 mg/kg. These results showed that C. verum extracts are potential antipiroplasm drugs after further studies in some clinical cases.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: In Vitro Drug Combination Testmentioning

confidence: 99%

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Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo

et al. 2020

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“…Actualmente, existen estudios realizados con los aceites esenciales de diversas plantas del género Piper como los mencionados en la revisión realizada por Pérez et al (2012), donde se indica la actividad de los aceites esenciales de Piper aduncum contra Leishmania amazonensis; y se reporta además que la actividad de Piper auritum es similar al medicamento anfotericina. Otro estudio muestra que el aceite esencial de Piper hispidinervum tuvo también actividad contra Leishmania infantum, con un CI 50 de 1.43 µg/mL (Bosquiroli et al, 2015).…”

Section: Discussionunclassified

Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae)

Rodríguez-Chaves

Bagnarello-Madrigal

Alpizar-Cordero

et al. 2018

RBT

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Anti-Leishmania (Trypanosomatidae) activity of trans-Z-α-bisabolene epoxide and isolation of safrole, in fruits of Piper auritum (Piperaceae). The leishmaniosis disease incidence is high in tropical regions, and its current treatment has shown severe secondary effects. Considering this problem, many studies have focused on plants, looking for chemical components that have anti-leishmanial activity, and are free of adverse effects for human beings. The purpose of this work was to find a chemical component with this kind of activity in Piper auritum. In a phytochemical screening of this plant, we found some cumarins, terpens, triterpens and reducing sugars; and later, we identified the components trans-Z-α-bisabolene epoxide and Safrol. The first component presented a CI50 of 50.0 µg/mL of anti-Leishmania activity. The Safrol, which is the major component of the essential oils of this plant, did not show antiparasitic activity. These results are discussed considering treatment of leishmaniasis. Rev. Biol. Trop. 66(2): 826-835. Epub 2018 June 01.

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“…Monoterpenes with this type of activity is still to be investigated, despite of a number of medicinal plants have been introduced having anti-leishmaniasis potential [36][37][38][39][40][41][42][43][44]. Saponins from Calliandra pulcherrima and Quillaja saponaria were found to exhibit significant anti-leishmaniasis activity against Leishmania donovani and L. chagasi.…”

Section: Anti-leishmaniasis and Anti-chagas Disease Potentialsmentioning

confidence: 99%

Applications of monoterpenic essential oils in neglected diseases: nerol in a prospection

Coêlho¹,

Islam²,

Moura³

et al. 2016

Int Arch Med

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Monoterpenes are the naturally occurred essential oils in various plant species having a wide range of biological activities. Attentions on the natural compounds, especially those are plant-derived is growing day by day. Nerol, a monoterpene having some important biological activities along with its other applications, may be a hopeful tool in this context. By considering the above circumstances, this study aimed to perform a scientific and technological prospective study on this charming monoterpene with an emphasis on the treatment of neglected diseases along with other monoterpenes. We conducted a comprehensive and systematic search for published articles, periodicals, magazines in the CAPES, ScienceDirect and Pubmed, while for patents we have gone through search in National Institute of Industrial Property of Brazil (INPI), European Patent Office (EPO), World Intellectual Property Organization (WIPO) and United States Patent and Trademark Office (USPTO). Results suggesting monoterpenes have therapeutic potentials against malaria, dengue, schistosomiasis, tuberculosis, leprosies, leishmaniasis and chagas diseases. Nerol has anti-tuberculosis potential. In conclusion, more researches are recommenced with nerol in a context of treatment of neglected diseases.

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In vitro anti-Leishmania infantum activity of essential oil from Piper angustifolium

Cited by 32 publications

References 32 publications

Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo

Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo

Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae)

Applications of monoterpenic essential oils in neglected diseases: nerol in a prospection

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