In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-d-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells

Characterization of the bioactive constituents of Nymphaea alba rhizomes and evaluation of anti-biofilm as well as antioxidant and cytotoxic properties

“…This was in agreement with Oh et al (2001) who isolated PGG from the root of Paeonia suffruticosa and tested its in vitro effect on human hepatocellular carcinoma SK-HEP-1 cells. Up to 50 μM PGG inhibited the growth of SK-HEP-1 cells in a dosedependent fashion and 30 μM PGG significantly induced G1 arrest.…”

The Genome-Wide Expression Profile of l,2,3,4,6-Penta-O-Galloyl-β-D-Glucose-Treated MDA-MB-231 Breast Cancer Cells: Molecular Target on Cancer Metabolism

“…PGG is one of plant secondary metabolites from many medicinal herbs such as Rhus chinensis Mill (Huh al., 2005), Acer truncatum Bunge , Pelargonium inquinans Ait (Ji et al, 2005), and Paeonia lactiflora Pall . PGG has been reported to have anti-cancer activities via proapoptosis, anti-angiogenesis, anti-metastasis and anti-proliferation in many types of cancer including prostate cancer (Kuo et al, 2009), lung cancer (Huh et al, 2005), melanoma (Ho et al, 2002), liver cancer (Oh et al, 2001) and leukemia (Pan et al, 1999). PGG also showed anti-oxidative (Riedl and Hagerman, 2001), anti-mutagenic (Okuda et al, 1984), anti-inflammatory (Pan et al, 2000), anti-allergic (Cavalher-Machado et al, 2008) and anti-kidney stone formation activities in vitro and in vivo.…”

“…1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) (Fig. 1) is a water soluble gallotannin polyphenolic compound (Hofmann and Gross, 1990) isolated from gallnut of Rhus chinensis Mill, Acer truncatum Bunge, Pelargonium inquinans Ait, and Paeonia lactiflora Pall exhibiting anti-tumor, anti-angiogenesis and antidiabetic activities (Huh et al, 2005;Li et al, 2005;Oh et al, 2001;Pan et al, 1999;Zhang et al, 2009). PGG induced apoptosis through caspase-3 activation in human leukemia cells (Pan et al, 1999) and mediated cell cycle arrest at the G1 phase by targeting cyclin D1 in human hepatocellular carcinoma and prostate cancer cells (Hu et al, 2009b;Oh et al, 2001).…”

Penta-O-galloyl-beta-D-glucose enhances antitumor activity of imatinib and suppresses the growth of K562 cells in mice

“…Also, it is of note that PGG exerts antitumor activity in various cancers such as prostate (Hu et al, 2008), lung (Huh et al, 2005), breast (Chen et al, 2003), melanoma (Ho et al, 2002), liver cancers (Oh et al, 2001) and sarcomas (Miyamoto et al, 1987). Nevertheless, there are no evidences regarding the synergistic antitumor effect of PGG with imatinib so far.…”