In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia

Jiwajinda, Suratwadee; Santisopasri, Vilai; Murakami, Akira; Kawanaka, Masanori; Kawanaka, Hiromu; Gasquet, M.; Eilas, Riad; Balansard, G.; Ohigashi, Hajime

doi:10.1016/s0378-8741(02)00160-5

Cited by 84 publications

(61 citation statements)

References 10 publications

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“…Litsea elliptica Blume of the Lauraceae family is widely found in the region of South East Asia (Jiwajinda et al, 2002). Extracts of its leaves are used in the traditional native herbal medicine to treat conditions such as stomach ulcers, fever and headache (Grosvenor et al, 1995;Jiwajinda et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Taib

Budin

Ain

et al. 2009

J. Zhejiang Univ. Sci. B

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Litsea elliptica Blume leaves have been traditionally used as medicinal herbs because of its antimutagenicity, chemopreventative and insecticidal properties. In this study, the toxic effects of L. elliptica essential oil against Sprague-Dawley rat's red blood cells (RBCs) were evaluated. L. elliptica essential oil was given by oral gavage 5 times per week for 3 treated groups in the doses of 125, 250, and 500 mg/(kg body weight), respectively, and the control group received distilled water. Full blood count, RBC osmotic fragility, RBC morphological changes, and RBC membrane lipid were analyzed 28 d after the treatment. Although L. elliptica essential oil administration had significantly different effects on hemoglobin (Hb), mean cell hemoglobin concentration (MCHC), mean cell volume (MCV), and mean cell hemoglobin (MCH) in the experimental groups as compared to the control group (P<0.05), the values were still within the normal range. L. elliptica induced morphological changes of RBC into the form of echinocyte. The percentage of echinocyte increased significantly among the treated groups in a dose-response manner (P<0.001). The concentrations of RBC membrane phospholipids and cholesterol of all treated groups were significantly lower than those of control group (P<0.001). However, the RBC membrane osmotic fragility and total proteins of RBC membrane findings did not differ significantly between control and treated groups (P>0.05). It is concluded that structural changes in the RBC membrane due to L. elliptica essential oil administration did not cause severe membrane damage.

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Section: Introductionmentioning

confidence: 99%

“…Extracts of its leaves are used in the traditional native herbal medicine to treat conditions such as stomach ulcers, fever and headache (Grosvenor et al, 1995;Jiwajinda et al, 2002). A significant antimutagenic activity has also been reported (Nakahara et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Taib

Budin

Ain

et al. 2009

J. Zhejiang Univ. Sci. B

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“…The in vitro antischistosomal activity of the A.indica leaves extract or the isolated compounds was performed according to the method described by Jiwahinda et al (16) . Briefly, in polystyrene Petri dish (3.5 x 10 mm), ten adult Schistosoma mansoni worms were cultured in 10 ml sterile RPMI-1640 media with graduated extracts from 10 µg/ml to 100 µg/ml at 37 °C for 24 hr .The negative control consisted of 10 adult worms cultured in RPMI-1640 media and 10 % DMSO whereas the positive control consisted of 1 mmol PZQ and incubated for 24 hr at 37 °C .…”

Section: In Vitro Antischistosomal Assaymentioning

confidence: 99%

Chemical Constituents, Antischistosomal and Antioxidant Activities of the Methanolic Extract of Azadirachta indica

2011

Egypt. J. Chem.

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HE PRESENT study was performed to evaluate the in vitro …….. schistosomicidal effect of 70% methanolic extract of the leaves of Azadirachta indica and its derived ethyl acetate and n-butanol fractions against adult Schistosoma mansoni worms. Also, antioxidant properties of these extracts were determined. Owing to the high antischistosomal and antioxidant activities of EtOAc and n-BuOH fractions, they were subjected to chromatographic isolation using different chromatographic techniques. Two flavonoid compounds; (1,2) were isolated from EtOAc fraction whereas one flavonoid; (3) quercetin-3-O-α-L-rhamnopyranoside and two bidesmosidic saponins; (4,5) were isolated from the butanolic fraction. Their structures were established using spectroscopic methods. Compounds 1-3 showed high antioxidant activity whereas compounds 4 and 5 were inactive. It is the first time that antischistosomal activity of A.indica and isolation of compounds 2-5 from this plant were carried out.

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“…A excelsina (100) é também muito ativa (0,2 µM; 0,096 µg mL -1 ), uma vez que a cloroquina (droga comercial) mostrase efetiva na concentração de 0,025 µM (0,008 µg mL ). Esses valores foram bem superiores aos registrados para outros quassinóides C 20 com ponte oximetilênica entre C-8 e C-11, também encontrados E. longifolia 78 . A partir dos resultados obtidos, foi possível relacionar várias características estruturais à atividade antimalárica, tais como a presença de uma hidroxila livre e o padrão de substituição e oxidação no anel A; a presença da ponte de éter entre C-8 e C-11 ou C-13 77,78 e, a presença de substituintes em C-15 76 .…”

Section: Atividade Antimaláricaunclassified

Ocorrência e atividade biológica de quassinóides da última década

Almeida¹,

Arriaga²,

Santos³

et al. 2007

Quím. Nova

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In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia

Cited by 84 publications

References 10 publications

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Chemical Constituents, Antischistosomal and Antioxidant Activities of the Methanolic Extract of Azadirachta indica

Ocorrência e atividade biológica de quassinóides da última década

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