In vitro anti-venom potential of various solvent based leaf extracts of Andrographis serpyllifolia (Rottler ex Vahl) Wight against Naja naja and Daboia russelli

Hansiya, V.S.; Geetha, N.

doi:10.1016/j.jep.2020.113687

Cited by 3 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This plant can be used to treat fever, wounds, and jaundice with its root extract and extract from the leaves (Alagesaboopathi, 2000). A. serpyllifolia leaf extracts have shown anti-venom activities against toxic venom enzymes of snakes in vitro (Balu and Alagesaboopathi, 1995;Hansiya and Geetha, 2021). The chemical investigation of A. serpyllifolia revealed the presence of serpyllin, a new flavone (Govindachari et al, 1968).…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

SOUNDARYA,

KARMEGAM

2023

Not Sci Biol

View full text Add to dashboard Cite

Nanoparticles (NPs) play a significant role in protecting human and environmental health. Worldwide, research is focused on developing new pharmaceuticals and environmentally safe materials. The current research reports the phytosynthesis of NPs from iron oxide (Fe2O3) mediated through ethanolic extracts of Andrographis serpyllifolia leaf (ASL) and their antimicrobial (bacteria and fungi) and mosquito (Culex quinquefasciatus) larvicidal activity. ASL was treated with aqueous iron chloride solution to turn into synthesized Fe2O3-NPs. The biosynthesized ASL·Fe2O3-NPs were characterized with spectroscopic, electron microscopic and X-ray analyses. The synthesized ASL·Fe2O3-NPs were characteristically showed triclinic crystal shape in SEM. The purity of synthesized Fe2O3 nanoparticles was confirmed by FT-IR analysis. Out of twelve different selective pathogens (4 G+ve bacteria, 4 G-ve bacteria and 4 fungal species) tested with ASL·Fe2O3-NPs, a maximum of 20.3 mm inhibition zone against Staphylococcus aureus among G+ve bacteria and 19.1 mm inhibition zone against Pseudomonas aeruginosa among G-ve bacteria was observed; while it was 16.9 mm against fungi (Aspergillus niger) at a test concentration of 100 µL. The exposure of 4th instar larvae for 48 h to ASL·Fe2O3-NPs exhibited a significant LC50 value at 12.80 ppm. The study findings reveal that the Fe2O3‑NPs synthesized using A. serpyllifolia leaf extract could be a potential source for antibacterial, antifungal and mosquito larvicidal activities.

show abstract

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

SOUNDARYA,

KARMEGAM

2023

Not Sci Biol

View full text Add to dashboard Cite

show abstract

“…In view of the fact that plant‐derived natural products or their scaffolds feature often in many pharmaceuticals, it is conceivable that the huge library of plant‐derived medicinal compounds if explored, can deliver the next generation of therapeutics to combat the lethality of SBE. As such, the search for antivenin medicinal plants or plant‐derived metabolites that can address the perennial burden of SBE has therefore been an active research area in many academic laboratories, [24–28] especially in regions where the burden of the disease is enormous.…”

Section: Introductionmentioning

confidence: 99%

Prospects and Challenges of Developing Plant‐Derived Snake Antivenin Natural Products: A Focus on West Africa

et al. 2021

View full text Add to dashboard Cite

Snakebite envenomation (SBE) is an important public health issue that is now receiving renewed attention following its reclassification as a Neglected Tropical Disease (NTD). Most incidences occur in rural areas of resource‐limited countries, as such, timely and appropriate medical care for SBE is often inaccessible. The administration of anti‐snake venom serum (ASV) is the only effective definitive treatment of SBE, but treatment failure to available ASVs is not uncommon. Emerging evidence highlights the potential of small‐molecule compounds as inhibitors against toxins of snake venom. This presents an encouraging prospect to develop an alternative therapeutic option for the treatment SBE, that may be amenable for use at the point of care in resource‐constraint settings. In view of the pivotal role of natural products in modern drug discovery programmes, there is considerable interest in ethno‐pharmacological mining of medicinal plants and plant‐derived medicinal compounds toward developing novel snake venom‐neutralising therapeutics. In this review, we compile a collection of medicinal plants used in the treatment of SBE in West Africa and highlight their promise as potential botanical drugs or as sources of novel small‐molecule compounds for the treatment of SBE. The challenges that must be surmounted to bring this to fruition including the need for (sub) regional collaboration have been discussed.

show abstract

Proteomic diversity of Russell's viper venom: exploring PLA2 isoforms, pharmacological effects, and inhibitory approaches

Srinivasan,

Nampoothiri,

Khandibharad

et al. 2024

Arch Toxicol

View full text Add to dashboard Cite

Snakebite envenomation is a serious health concern in tropical regions, resulting in high mortality. The World Health Organization (WHO) has declared it a neglected tropical disease and is working on strategies to reduce mortality. Russell’s viper (Daboia russelii) is one of the most abundant venomous snakes found across Southeast Asia. Proteomic analysis of Russell’s viper venom has demonstrated variation, with phospholipase A2 (PLA2) being the most abundant toxin across geographic boundaries. PLA2, a major constituent of the low-molecular-weight fraction of snake venom, hydrolyses phospholipids at the sn-2 position, releasing arachidonic acid and lysophospholipids. They are reported to cause various pharmacological effects, including hemolysis, anticoagulation, neurotoxicity, myotoxicity, and oedema. Though administration of antivenoms (ASV) is the primary treatment for envenomation, it has many drawbacks. Besides causing hypersensitivity reactions and life-threatening anaphylaxis, treatment with ASV is further complicated due to its inability to neutralize low-molecular-weight toxins. Thus, there is a greater need to produce next-generation antivenoms that can target specific toxins in the venom. In this review, we explored the classification of Russell’s viper and the variation in its proteomic profile across Southeast Asia to date. In addition, we have also summarized the mechanism of action of PLA2 and discussed various isoforms of PLA2 found across different regions with their respective pharmacological effects. Finally, the drawbacks of commercially available antivenoms and the molecules investigated for inhibiting the low-molecular-weight toxin, PLA2 are discussed.

show abstract

In vitro anti-venom potential of various solvent based leaf extracts of Andrographis serpyllifolia (Rottler ex Vahl) Wight against Naja naja and Daboia russelli

Cited by 3 publications

References 52 publications

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

Antimicrobial and mosquito larvicidal activity of iron oxide nanoparticles phytosynthesized from the medicinal plant Andrographis serpyllifolia

Prospects and Challenges of Developing Plant‐Derived Snake Antivenin Natural Products: A Focus on West Africa

Proteomic diversity of Russell's viper venom: exploring PLA2 isoforms, pharmacological effects, and inhibitory approaches

Contact Info

Product

Resources

About