In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci

Kim, Jong Bae; Lee, Gyu Sang; Kim, Yun Bong; Kim, Soo Kie; Kim, Yong Hae

doi:10.1016/j.ijantimicag.2004.03.018

Cited by 19 publications

(13 citation statements)

References 10 publications

(11 reference statements)

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“…In the past decades, resistance against these important drugs developed with increasing frequency around the world (J. Kim, G. Lee, Y. Kim, S. Kim, & Y. H. Kim, 2004;Rosenberg, Jarvis, Abbott, & Vugia, 2004;Stiefel et al, 2004). The spreading potential of resistance is an important issue since vancomycin resistance genes could be transferred among enterococci and from enterococci to staphylococcus species (Kacmaz & Aksoy, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…The results of the study agree with those Junco et al (2001). Despite, the reported increase in the incidences of vancomycin resistant enterococci (VRE) strains in hospitals throughout the world (Kim et al, 2004;Rosenberg et al, 2004;Stiefel et al, 2004) this has yet to be observed in clinical specimens in Turkey (Kacmaz & Aksoy, 2005;Moaddab & Toreci, 2000). The current work is the first investigation in respect to determination of heavy metals and antibiotics resistance of environmental Enterococcus strains in Istanbul.…”

Section: Discussionmentioning

confidence: 99%

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Isolation and Identification of Enterococci from Seawater Samples: Assessment of Their Resistance to Antibiotics and Heavy Metals

Kimiran-Erdem

Arslan

Yurudu

et al. 2006

Environ Monit Assess

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A hundred Enterococcus strains were isolated from seawater samples collected from coastal areas of Istanbul. Isolates were identified to the species level using standard biochemical tests specified by Facklam and Collins. The species distribution was as follows Enterococcus faecalis (96%), Enterococcus gallinarum (3%) and Enterococcus solitarius (1%). The resistance of bacteria to both heavy metals (zinc [Zn], iron [Fe], cadmium [Cd], chrome [Cr], cobalt [Co]) and antibiotics (ampicillin 10 microg [AP], penicillin G 10 Units [PG], gentamycin 10 microg [GM], streptomycin 10 microg [S], chloramphenicol 10 microg [C], erythromycin 15 microg [E], kanamycin 30 microg [K], amikacin 30 microg [AK], nalidixic acid 30 microg [NA], and vancomycin 30 microg [VA]) was evaluated. None of the strains was resistant to VA. It was found that among the 100 isolates, those that exhibit resistance to antibiotics, particularly NA, S and K, were also resistant all the heavy metals tested. To our knowledge this is the first report focusing on determination of resistance of environmental enterococci found in Istanbul against heavy metals and antibiotics. Thus, combined expressions of antibiotic and heavy metal resistance may help to reinforce ecological and epidemiological studies and to determine the role of these strains in antibiotic and heavy metal resistance dissemination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Isolation and Identification of Enterococci from Seawater Samples: Assessment of Their Resistance to Antibiotics and Heavy Metals

Kimiran-Erdem

Arslan

Yurudu

et al. 2006

Environ Monit Assess

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“…13 Synthesizing this evidence, we rationally hypothesized that echinomycin would be active against MRSA and methicillin-susceptible S. aureus (MSSA). To address this issue, we examined the in vitro and in vivo activities of echinomycin against clinical isolates of S. aureus by employing the MIC and MBC assay, the time -kill assay, as well as an in vivo protection model.…”

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confidence: 99%

In vitro and in vivo activities of echinomycin against clinical isolates of Staphylococcus aureus

Park

Shin

Kim

2007

Journal of Antimicrobial Chemotherapy

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Objectives: To verify in vitro and in vivo activities of echinomycin against clinical isolates of Staphylococcus aureus, we compared antistaphylococcal activities of echinomycin with those of vancomycin.Methods: In vitro activities (MICs and MBCs) of oxacillin, vancomycin and echinomycin against 18 isolates of methicillin-susceptible S. aureus (MSSA) and 118 isolates of methicillin-resistant S. aureus (MRSA) were compared. Using four representative isolates of S. aureus, time-kill assay and in vivo antistaphylococcal activities were assessed. Echinomycin and vancomycin were compared in an in vivo mouse infection model.Results: Echinomycin demonstrated higher in vitro activities against MSSA and MRSA strains, exhibiting 2-fold lower MIC 90 s and 4-fold lower MBC 90 s than vancomycin. Additionally, time-kill assay indicated that echinomycin is more potent than vancomycin against MSSA and MRSA strains in the context of MICs and MBCs. Using an in vivo protection model, it was shown that the 50% effective doses of echinomycin were at least 7-fold lower than those of vancomycin. Therefore, echinomycin displayed excellent protection in mice against acute peritoneal infections caused by both MSSA and MRSA strains.Conclusions: Collectively, these data indicate that the activity of echinomycin against S. aureus strains is at least equivalent to that of vancomycin, regardless of the methicillin resistance of these strains. These promising activities of echinomycin might justify its potential use against infections with S. aureus strains resistant to vancomycin. This might be the first report to show that echinomycin possesses antipathogenic staphylococcal activity.

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“…Nonetheless, recent reports highlight the increasing number of patients that are infected by strains resistant to these types of glycopeptides, especially vancomycin (Barreto et al 2009;Klare et al 1995a;Van der Auwera et al 1996). Resistant E. faecalis strains presenting resistance to the above-mentioned glycopeptides have also been detected in nosocomial infections (Cetinkaya et al 2000;Goossens 1999;Klare et al 2003;Low et al 2001;Meyer et al 2010;Rice et al 2003), infected animals (Aarestrup et al 1996;Bates et al 1994;Klare et al 1995b), and in water treatment plants (Bates et al 1994;Kim et al 2004;Klare et al 1993;Torres et al 1994), which constitute a major source of infectious agents for the general population.…”

Section: Resultsmentioning

confidence: 99%

Identification of Enterococcus faecalis bacteria resistant to heavy metals and antibiotics in surface waters of the Mololoa River in Tepic, Nayarit, Mexico

Mondragón

Llamas-Pérez

González-Guzmán

et al. 2011

Environ Monit Assess

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Heavy metal and antibiotic resistance have been shown to have a strong correlation in nature, and their inter-relation is an important subject of study. We report an analysis of surface waters of the Mololoa River in the municipality of Tepic, state of Nayarit, Mexico. This river has two distinctive sources of contamination: sewage waters and trash confinements. Our findings demonstrate a correlation between the river flow pattern and resistance to heavy metals or to heavy metals and antibiotics in isolated bacteria of the genus Enterococcus, specifically Enterococcus faecalis. The Mololoa River provides a model to study the relationship between water flow and generation of biodiversity, and more importantly, it constitutes a model for studying genetic diversity of bacteria affecting human health.

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In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci

Cited by 19 publications

References 10 publications

Isolation and Identification of Enterococci from Seawater Samples: Assessment of Their Resistance to Antibiotics and Heavy Metals

Isolation and Identification of Enterococci from Seawater Samples: Assessment of Their Resistance to Antibiotics and Heavy Metals

In vitro and in vivo activities of echinomycin against clinical isolates of Staphylococcus aureus

Identification of Enterococcus faecalis bacteria resistant to heavy metals and antibiotics in surface waters of the Mololoa River in Tepic, Nayarit, Mexico

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