In vitro antibacterial activity of leaf extracts of Zehneria scabra and Ricinus communis against Escherichia coli and methicillin resistance Staphylococcus aureus

Abew, Bereket; Sahile, Samuel; Moges, Feleke

doi:10.12980/apjtb.4.201414b16

Cited by 30 publications

(39 citation statements)

References 5 publications

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“…Zehneria scabra (traditionally used as medicinal plant) leaf extract MIC value against E. coli was 250 mg/mL (Abew et al . ) and MIC value of the methanolic extract of garlic root (commonly used as spice and to treat many diseases) against S. aureus was 100 mg/mL (Garba et al . ).…”

Section: Resultsmentioning

confidence: 99%

Potential Antioxidant and Antibacterial Properties of a Popular Jujube Fruit: Apple Kul (Zizyphus mauritiana)

Afroz

Tanvir

Islam

et al. 2014

Journal of Food Biochemistry

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The purpose of the present study was to investigate the antioxidant and antimicrobial activities of a methanolic extract of Apple kul (Zizyphus mauritiana) as it has not been studied extensively. Apple kul was found to be a rich source of polyphenols (52.19 ± 2.38 mg gallic acid equivalents/100 g), flavonoids (13.19 ± 1.31 mg catechin equivalents/100 g), ascorbic acid (48.17 ± 2.04 mg ascorbate equivalent/100 g) and tannins (50.20 ± 3.61 mg tannic acid equivalents/100 g). The estimated protein and reducing sugar contents in Apple kul were 1.21 ± 0.04 g/100 g and 1.96 ± 0.15 g/100 g, respectively. The high ferric‐reducing antioxidant power value (6336.71 ± 554.88 μmol Fe [II]/g) also indicated a high antioxidant potency for Apple kul. Apple kul showed highest activity towards Pseudomonas aeruginosa and Staphylococcus aureus. Practical Applications Apple kul is full of vital potential antioxidants and can act as an antimicrobial agent, which is beneficial to fight against oxidative stress associated diseases as well as against harmful bacteria to maintain a healthy human life.

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Section: Resultsmentioning

confidence: 99%

Potential Antioxidant and Antibacterial Properties of a Popular Jujube Fruit: Apple Kul (Zizyphus mauritiana)

Afroz

Tanvir

Islam

et al. 2014

Journal of Food Biochemistry

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“…The study on validation of antimicrobial activity of Ricinus communis Linn leaf crude extracts are conducted using different solvents in Pakistan and Ghana, and methanol crude extract is reported to have a promising antimicrobial potential [14,15]. Besides, in Ethiopia Ricinus communis Linn leaf has shown an antibacterial activity for an organic solvent solution, but the aqueous extract has shown less activity [16].…”

Section: Introductionmentioning

confidence: 99%

“…However, methanol solvent was not used for extraction in Abew et al [16] study and none has been done on the antimicrobial activities of solvent fractions of Ricinus communis Linn leaf.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in-vitro antibacterial and antifungal activities of crude extracts and solvent fractions of methanol extract of leaves of Ricinus communis Linn (Euphorbiaceae) against selected pathogens

Kebede¹

2020

Preprint

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Background Impacts of infectious diseases are reduced due to development of antimicrobial agents. However, the effectiveness of the antimicrobial agents is reduced over time because of the emergence of antimicrobial resistance.To overcome these problems scholars have been searching for alternative medicines, particularly focusing on traditionally used medicinal plants. Ricinus communis Linn is used as a traditional treatment for bovine mastitis, wound infection, and other medicinal purposes. Moreover, the antimicrobial activity of Ricinus communis Linn leaf at crude extract level has been confirmed against human originated pathogens in the previous studies. The objective of the present study was to further evaluate the antimicrobial activities of Ricinus communis Linn leaf extracts and fractions. The Ricinus communis Linn leaves were macerated in absolute methanol and acetone solvents. The methanol crude extract was shown best antimicrobial activity and exposed to further fractionation via increasing polarity of solvents (n-hexane, chloroform, ethyl acetate, and aqueous). Test microorganisms included in the study were six laboratory reference bacteria (E. coli, S. aureus, S. agalactiae, K. pneumoniae, P. aeruginosa, and S. Pyogenes), two clinical isolate bacteria (E. coli and S. aureus), and Candida albicans. The agar well diffusion method was employed to determine antimicrobial activity. The minimum inhibitory concentrations (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC) were determined through broth microdilution method. Results The results indicated that the best antimicrobial activity(based on zone of inhibition) for ethyl acetate fraction ranging from 14.67 mm (clinical E. coli) to 20.33 mm (S. aureus) at 400mg/ml however, n-hexane exhibited lowest antimicrobial activity. Among tested fractions, ethyl acetate fraction was produced lowest MIC values ranging from 1.5625mg/ml (S. aureus) to 16.67 mg/ml (Candida albicans). The ethyl acetate fraction showed bactericidal activity against all tested microorganisms. Conclusion Methanol extract of Ricinus communis Linn leaf exhibited better antimicrobial activity than acetone extract. Hence, ethyl acetate fraction of crude methanol extract exhibited best antimicrobial activity indicating its potential for development of antimicrobial products.

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“…compounds that are directly or indirectly derived from plants 2 . Medicinal plants have been used for centuries as remedies for human diseases, Nowadays there is a wide spread interest in medicines derived from plants, and it is reported that green medicine is safe and reliable because they contain components and secondary metabolites such as polyphenols, alkaloids, volatile oils and etc which have therapeutic properties so formulation of plants for standardization and regulation of phytomedicinal products is the most alternative way 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…Global emergence of resistant bacteria is the result of ineffectiveness of current antibiotics and drugs causing treatment failure 7 . Hence there has been a growing interest by using alternative therapy and the therapeutic use of natural products specially medicinal plant 3 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

IJPSR

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Chenopodium album (sub sp. striatum) is a folk and nutritious medicine belongs to Chenopodiaceae family and widely used as antimicrobial agent. The aim of this study is to evaluate the in vitro antibacterial potential against multidrug-resistance (MDR) bacteria isolated from clinical spicemens, antioxidant activity, total phenolic and total flavonoids content of crude ethanolic extract and nine different fractions of C. album (sub sp. striatum). The in vitro antibacterial activity was evaluate against eight multidrug-resistant bacteria based on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), agar well and disk diffusion methods. Antioxidant property was evaluated by 1, 1-diphenyl-2-picryl-hydrazyl radical scavenging activity. The total phenol contents were measured by Folin-Ciocalteu and AlCl 3 assays. Our results showed that MeOH: H 2 O with 80:20 ratio (most polar) fraction had the highest antimicrobial effect on eight multidrug-resistant bacteria (MIC: 0.15-2.5 mg/ml, MBC: 0.31-5 mg/ml and had highest inhibitation zones (well: 24.33±0.57 mm and disk: 26.33±1.53 mm). In antioxidant assay, MeOH: H 2 O fraction also exhibited the highest radical scavenging activity [Antioxidant activity = 95.1±2.13 percent] and flavonoid content of crude ethanolic extract and most polar fraction were the highest [(0.892±0.011, 0.865±0.010) mg/ml and (4.873±0.029, 4.535±0.025) mg/ml]. According to our result, C. album (sub sp. striatum) has the greatest potential to be consider as antibacterial (against MDR bacteria strain) and antioxidant agent, but further in vivo research, isolation of pure compounds should be carried out to discover the modes of its action and to shed light on the effects.

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In vitro antibacterial activity of leaf extracts of Zehneria scabra and Ricinus communis against Escherichia coli and methicillin resistance Staphylococcus aureus

Cited by 30 publications

References 5 publications

Potential Antioxidant and Antibacterial Properties of a Popular Jujube Fruit: Apple Kul (Zizyphus mauritiana)

Potential Antioxidant and Antibacterial Properties of a Popular Jujube Fruit: Apple Kul (Zizyphus mauritiana)

Evaluation of in-vitro antibacterial and antifungal activities of crude extracts and solvent fractions of methanol extract of leaves of Ricinus communis Linn (Euphorbiaceae) against selected pathogens

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