In vitro antibacterial activity of crude extracts of 9 selected medicinal plants against UTI causing MDR bacteria

Mishra, Monali P.; Rath, Sibanarayan; Swain, Shasank S.; Ghosh, Goutam; Das, Debajyoti; Padhy, Rabindra N.

doi:10.1016/j.jksus.2015.05.007

Cited by 75 publications

(48 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Wan et al [35] also determined the antibacterial activities of Q. infectoria that MIC values of the ethanolic extract against multidrug-resistant bacteria were in the range of 0.03 to 0.63 mg/mL, indicating their strong antibacterial activities. Other TCMP extracts with good antibacterial activities against other bacterial pathogens reported in other studies [39][40][41], are in agreement with the results in Table 2. The observed slight differences in the susceptibility of test bacteria were due to different solvents, extraction methods, antibacterial test methods, harvesting time, and the variation in the proportion of bioactive compounds.…”

Section: Selected Tcmp Extracts With a Wide Range Of Antibacterial Acsupporting

confidence: 92%

Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant Staphylococcus aureus and Cytotoxic Activities

et al. 2020

View full text Add to dashboard Cite

Novel alternative antibacterial compounds have been persistently explored from plants as natural sources to overcome antibiotic resistance leading to serious foodborne bacterial illnesses. In this study, the ethanolic extracts from 239 traditional Chinese medicinal plants (TCMP)’ materials were screened to discover promising candidates that have strong antibacterial properties against multidrug-resistant Staphylococcus (S.) aureus and low cytotoxicity. The results revealed that 74 extracts exhibited good antibacterial activities (diameter of inhibition zone (DIZ) ≥ 15 mm). Furthermore, 18 extracts (DIZ ≥ 20 mm) were determined their minimum inhibitory concentrations (MIC) and minimum bactericide concentrations (MBC), ranging from 0.1 to 12.5 mg/mL and 0.78 to 25 mg/mL, respectively. In addition, most of the 18 extracts showed relatively low cytotoxicity (a median lethal concentration (LC50) >100 µg/mL). The 18 extracts were further determined to estimate possible correlation of their phenolic contents with antibacterial activity, and the results did not show any significant correlation. In conclusion, this study selected out some promising antibacterial TCMP extracts with low cytotoxicity, including Rhus chinensis Mill., Ilex rotunda Thunb., Leontice kiangnanensis P.L.Chiu, Oroxylum indicum Vent., Isatis tinctorial L., Terminalia chebula Retz., Acacia catechu (L.f.) Willd., Spatholobus suberectus Dunn, Rabdosia rubescens (Hemsl.) H.Hara, Salvia miltiorrhiza Bunge, Fraxinus fallax Lingelsh, Coptis chinensis Franch., Agrimonia Pilosa Ledeb., and Phellodendron chinense C.K.Schneid.

show abstract

Section: Selected Tcmp Extracts With a Wide Range Of Antibacterial Acsupporting

confidence: 92%

Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant Staphylococcus aureus and Cytotoxic Activities

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Plant extracts used in combination with the antibiotic can be water extract, extracts of different solvents in different parts of plant or a serum containing plant extracts (Ahmad & Aqil, 2007). Compared with herbal medicine, antibiotics are easier to cause the problem of bacterial resistance due to their composition is clear and single while these herbal medicine own complex and varied composition (Schwarz, Kehrenberg & Walsh, 2001; Mishra, Rath, Swain, Ghosh, Das & Padhy, 2017). Medicinal plants have antibacterial action in vitro, enhance the antibiotic activity(Barreto et al, 2016), delay or eliminate bacterial tolerance(Roy-Leon, Lauzon, Toye, Singhal & Cameron, 2005), while because they contain a variety of effective ingredients which are not easy to be separated completely, so these medicinal plants cannot easily replace antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of total flavonoids from Ilex rotunda Thunb. and different antibacterials on different multidrug-resistant bacteria alone or in combination

Chai

Wang

et al. 2018

Preprint

View full text Add to dashboard Cite

14The problem of bacterial resistance is becoming more and more serious, which 15 has become an urgent problem to be solved in human and veterinary. One approach to 16 control and delay bacterial resistance is combination therapy in which antibiotics are 17 given together with other antimicrobial or non-antimicrobial agents. Studies have 18 shown that flavonoids from Traditional Chinese medicine (TCM) possess a high level 19 of antibacterial activity against antibiotic resistant strains. The aim of this study was 20 to evaluate the antibacterial effects of a combined therapy of total flavonoids from 21 Ilex rotunda Thunb. and antibiotics against seven kinds of veterinary bacteria which 22 were multidrug resistance bacteria. A microdilution checkerboard method was used to 23 determine the minimal inhibitory concentrations of both types of antimicrobials, alone 24 and in combination. The fractional inhibitory concentration index was calculated and 25 used to classify observed collective antibacterial activity as synergistic, additive, 26 indifferent or antagonistic. 27 From the performed tests, the total flavonoids and antimicrobial agents were 28 combined to inhibit different multidrug-resistant bacteria, such as Escherichia coli, 29 Streptococcus, Pseudomonas aeruginosa, Enterococcus faecalis, Proteus vulgaris, 30 Staphylococcus aureus, Acinetobacter baumannii. For these bacteria, total flavonoids 31 from Ilex Rotunda Thunb. presented synergistic or additive with different antibiotics 32 and had a certain antibacterial effect on the separated multidrug-resistant bacteria. The 33 study shows total flavonoids from Ilex rotunda Thunb. have potential as adjuvants for 34 the treatment of animal bacterial diseases.35

show abstract

“…Previous study shows that T. cordifolia exhibit strong antimicrobial activity against gram positive and gram negative pathogens. In study conducted by Monali et al 2015, methanolic extract of T. cordifolia exhibit strong antibacterial activity against both gram positive and gram negative pathogens (Mishra et al, 2015). Study conducted by Shivam singh et al 2012 revealed that methanolic extract of T. cordifolia produces considerable antimicrobial activity (singh et al, 2012).On the basis of finding methanolic extract was selected for fractionation for indentifying the component involved in antimicrobial activity.…”

Section: Results:-susceptibility Testing:-mentioning

confidence: 99%

Phytochemical analysis and Biological studies of Indian medicinal plants Myristica fragrans and Tinospora cordifolia.

Jhorar¹,

Kaur²,

Tapan³

et al. 2016

IJAR

View full text Add to dashboard Cite

Mukherjee kumar Tapan.Phytochemical screening, isolation, antimicrobial and antioxidant activities of methanol, ethanol chloroform and water crude extracts of Myristica fragrans and Tinospora cordifolia were studied in this work. The aim of this work is to ascertain the level of antimicrobial activity and antioxidant properties of different solvent extracts of M. fragrans and T. cordifolia as well as isolated phytochemicals. The preliminary screening of various extracts was carried out using E. coli, C. sakazakii and P. aeruginosa by agar well diffusion method. The DPPH method used to determine the antioxidant potential of plant extracts and isolated phytochemicals. Myristicin and eugenol present in methanolic extracts exhibit direct relation with antimicrobial and antioxidant activity while palmatine and berberine could be responsible for T. cordifolia activities. The result showed that M. fragrans and T. cordifolia extracts have pharmocological active compounds with great antioxidant and antimicrobial effects. The results obtained from this study justify the use of this plant in traditional folk medicine and provide leads which could be further exploited for development of new and potent antimicrobials.Copy Right, IJAR, 2016,. All rights reserved.

show abstract

In vitro antibacterial activity of crude extracts of 9 selected medicinal plants against UTI causing MDR bacteria

Cited by 75 publications

References 31 publications

Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant Staphylococcus aureus and Cytotoxic Activities

Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant Staphylococcus aureus and Cytotoxic Activities

Antibacterial activity of total flavonoids from Ilex rotunda Thunb. and different antibacterials on different multidrug-resistant bacteria alone or in combination

Phytochemical analysis and Biological studies of Indian medicinal plants Myristica fragrans and Tinospora cordifolia.

Contact Info

Product

Resources

About