2012
DOI: 10.1016/j.ijantimicag.2011.10.008
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In vitro antibacterial and antimalarial activity of dehydrophenylalanine-containing undecapeptides alone and in combination with drugs

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Cited by 10 publications
(7 citation statements)
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“…Polycationic a-helical peptides have been reported to exhibit synergistic effects by enhancing the uptake of some antibiotics. [9][10][11][12][13][14][15] Small cationic cyclic peptides from the polymycin family have also been shown to exhibit synergy with small hydrophobic antibiotics. [16] Therefore, these cationic cyclooctapeptides, in their fast acting capacity to compromise the integrity of bacterial membranes, could present themselves as valuable synergists by enhancing the uptake of some antibiotics.…”
Section: Time Course Assaymentioning
confidence: 99%
See 1 more Smart Citation
“…Polycationic a-helical peptides have been reported to exhibit synergistic effects by enhancing the uptake of some antibiotics. [9][10][11][12][13][14][15] Small cationic cyclic peptides from the polymycin family have also been shown to exhibit synergy with small hydrophobic antibiotics. [16] Therefore, these cationic cyclooctapeptides, in their fast acting capacity to compromise the integrity of bacterial membranes, could present themselves as valuable synergists by enhancing the uptake of some antibiotics.…”
Section: Time Course Assaymentioning
confidence: 99%
“…[9][10][11][12][13] For example, recently Zhang et al reported in vitro synergistic activities of brevinin-2CE in combination with five kinds of antibiotics against clinical isolates of extended-spectrum b-lactamase producing E. coli and methicillin-resistant S. aureus. [14] Anti-methicillin-resistant S. aureus activity of mouse b-defensin 3 in combination with ampicillin has also shown synergism.…”
Section: Introductionmentioning
confidence: 99%
“…Based on the mechanism, glycine produce synergistic effect when combined with CAP, thereby increase its antibacterial effect. CAP / phenylalanine combination antibacterial effect was supported by the finding of (Cockburn et al, 1965;Sharma et al, 2012). The finding of Sharma et al ( 2012) states that phenylalanine (a peptide drug) produce synergistic effect when combined with nonpeptide drug and can be used to battle increasingly drug-resistant microbes.…”
Section: Discussionmentioning
confidence: 92%
“…These amino acids (phenylalanine and glycine) were effective because they were found to have protective and antibacterial effect. Their protective effects were confirmed by the studies of (Asakhiors et al, 2000;Yin et al, 2002;Zhou et al, 2005;Senthikumar et al, 2004;Para-vizuet et al, 2009;Yolande et al, 2011;Ponjit et al, 2011;Manion et al, 2011), while their antibacterial effect were supported by the studies of Minami et al, 2004;Sharma et al, 2012). Due to the limitations of most of the CAP toxicity reduction studies above and to sustain the therapeutic value of CAP in specific indications especially in developing countries, we decided to carry out study directly on bone marrow with the aim to study the effects of phenylalanine (an hydrophobic aromatic ring amino acid) and glycine (an hydrophilic straight chain amino acids) on haematological and histopathological profile of CAP-induced bone marrow toxicity in albino rats infected with Klebsiella pneumoniae.…”
Section: Introductionmentioning
confidence: 83%
“…Unlike these reports, in the case of cationic CPPs, we noticed that the removal of the supernatant (containing excess peptides) before the addition of a lysis buffer containing SG dye significantly reduced the number of false readouts of antiplasmodial activity of cationic CPP. In one report, the in vitro antiplasmodial activities of cationic undecapeptides were tested using the SG-based fluorescence assay; before adding the lysis buffer containing the SG dye, the supernatant was first removed after treatment to check for peptide-induced hemolysis of the treated cells (26). Although the antimalarial activity of the test peptide was not validated by other methods in that report, it is possible that, in line with our observation, the results were not affected due to the removal of excess peptides in solution.…”
mentioning
confidence: 99%