In vitro antibacterial, antifungal, and DNA cleavage studies of coumarin Schiff bases and their metal complexes: synthesis and spectral characterization

Patil, Sangamesh A.; Unki, Shrishila N.; Badami, Prema S.

doi:10.1007/s00044-011-9932-6

Cited by 24 publications

(19 citation statements)

References 34 publications

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“…The results are summarised in Table [3][4][5][6]. Disappointingly, the product was obtained in very low yield and a lot of the substrate was not consumed as indicated by TLC.…”

Section: Resultsmentioning

confidence: 99%

“…MCRs leading to interesting heterocyclic scaffolds are useful for the construction of diverse chemical libraries of 'drug like' molecules. 2,3 Coumarins are a widely distributed and important class of natural compounds with broad pharmacological activities including anti-tumour, 4 anti-bacterial, 5 anti-fungal, 6 anti-coagulant and anti-HIV activity. 7 Recently, several synthetic methodologies leading to coumarin derivatives have been developed.…”

mentioning

confidence: 99%

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An Efficient Protocol for Multicomponent Synthesis of 1H-chromeno[4,3-b] Pyridin-5(4H)-Ones Derivatives

Chen

2013

Journal of Chemical Research

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“…The results are summarised in Table [3][4][5][6]. Disappointingly, the product was obtained in very low yield and a lot of the substrate was not consumed as indicated by TLC.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

An Efficient Protocol for Multicomponent Synthesis of 1H-chromeno[4,3-b] Pyridin-5(4H)-Ones Derivatives

Chen

2013

Journal of Chemical Research

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“…The Schiff bases and their complexes have been screened for their antifungal activities against Aspergillus niger, Aspergillus flavus, and Cladosporium. The results of the studies show the metal complexes to be more effective antifungal as compared with the uncomplexed coumarins [55].…”

Section: Antifungal Activitymentioning

confidence: 96%

Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

Bitu¹,

Hossain²,

Zahid³

et al. 2019

AJHC

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Metals contribute important roles in biological system. It is recognized that metals are highly linked in cellular and subcellular functions. With the application of novel and experienced tools to study biological and biochemical systems the true role of inorganic salts in biological systems can be studied. Schiff base metal complexes show a broad range of biological activity. The activity of Schiff base ligand is usually increased by complexation with the metal ion. The copper complexes of Schiff bases have striking properties such as antibacterial, antifungal, antiviral, anti-inflammatory, anti-tumor and cytotoxic activities, plant development controller, enzymatic activity and applications in pharmaceutical fields. The divalent cations Zn 2+, Ca 2+ and Mg 2+ prevent cytotoxicity and in vivo antagonize Cd-induced carcinogenesis. Lack of body iron is common in cancer patients and it is associated with complications in surgery and in animal experiments. The transport of iron and other metal ions by the blood plasma is achieved through the formation of protein complexes. Copper is placed as a vital metalloelement and is primarily connected with copper-dependent cellular enzymes. Metals are also used as inorganic drugs for many diseases. In this review our main focused on research undertaken for biological activity study of Cu(II) metal complexes containing Schiff bases over the past few decades.

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“…[1][2][3][4][5][6] Schiff bases are potential antibacterial and anticancer drugs and, when administered as their metal complexes, the biological activities are often enhanced in comparison to the free ligands. [7][8][9] Fluoro has been considered to be a positive substituent group for the enhancement of biological activities. [10] The number of transition metal complexes of Co(III) and Cu(II) with oxygen and nitrogen donor Schiff base derivatives of 5-fluorosalicylaldehyde is limited.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structures, and Antibacterial Activities of Cobalt(III) and Copper(II) Complexes with Schiff Bases

Ren

Zhou

2014

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-

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A mononuclear cobalt(III) complex, [Co(L 1 ) 3 ] (1), and a dinuclear copper(II) complex, [Cu 2 Cl 2 (L 2 ) 2 ] (2), where L 1 and L 2 are the monoanionic form of 2-(cyclopropyliminomethyl)-4-fluorophenol and 4-fluoro-2-[(pyridin-2-ylmethylimino)methyl]phenol, respectively, have been prepared and structurally characterized by elemental analyses, infrared spectra, and single-crystal X-ray determination. Crystallographic data for 1: monoclinic, P2 1 , a D 10.6154 (7) A , b D 20.019(2) A , c D 13.693(1) A , b D 100.914(2) , V D 2857.2(4) A 3 , Z D 4, R 1 D 0.0701, wR 2 D 0.2033. The Co atom is in an octahedral coordination. Crystallographic data for 2: monoclinic, P2 1 /c, a D 12.543(2) A , b D 14.895(3) A , c D 7.078(2) A , b D 102.089(3) , V D 1293.1(5) A 3 , Z D 2, R 1 D 0.1032, wR 2 D 0.2179. The Cu atom is in a square pyramidal coordination. The antibacterial activities of the complexes and their respective Schiff bases have been tested against Gram(C) and Gram(-) bacteria.

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In vitro antibacterial, antifungal, and DNA cleavage studies of coumarin Schiff bases and their metal complexes: synthesis and spectral characterization

Cited by 24 publications

References 34 publications

An Efficient Protocol for Multicomponent Synthesis of 1H-chromeno[4,3-b] Pyridin-5(4H)-Ones Derivatives

An Efficient Protocol for Multicomponent Synthesis of 1H-chromeno[4,3-b] Pyridin-5(4H)-Ones Derivatives

Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

Synthesis, Structures, and Antibacterial Activities of Cobalt(III) and Copper(II) Complexes with Schiff Bases

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