In vitro Antibacterial Efficacy of &amp;lt;i&amp;gt;Bidens pilosa&amp;lt;/i&amp;gt;, &amp;lt;i&amp;gt;Ageratum conyzoides&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;Ocimum suave&amp;lt;/i&amp;gt; Extracts against HIV/AIDS Patients’ Oral Bacteria in South-Western Uganda

Ezeonwumelu, Joseph Obiezu Chukwujekwu; Ntale, Muhammad; Ogbonnia, Steve; Agwu, Ezera; Tanayen, Julius Kihdze; Kasozi, Keneth Iceland; Okonkwo, C. O.; Shodunke, Anthonia; Akunne, Ambrose Amamchukwu; Dafiewhare, Onokiojare Ephraim; Ebosie, Jennifer Chibuogwu; Byarugaba, Frederick

doi:10.4236/pp.2017.89023

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Pada studi tentang keberhasilan antibakteri ekstrak daun ketul terhadap bakteri mulut pasien HIV/AIDS secara in-vitro diperoleh bahwa ekstrak akuades dan ekstrak etanol dari daun Ketul memiliki konsentrasi hambat minimum (Minimum Inhibitory Concentration/MIC) terhadap Streptococcus mutans sebesar 0,01±0,06 µg/mL dan 0,11±0,15 µg/mL (Ezeonwumelu et al, 2017). Beberapa studi lain juga membuktikan aktivitas antibakteri tanaman ini.…”

Section: Pendahuluanunclassified

“…Dalam ekstrak etanol daun ketul (Bidens pilosa), yang berpotensi sebagai antibakteri adalah tannin (komponen fitokimia paling banyak ditemukan), glikosida jantung, saponin, alkaloid, steroid, dan flavonoid (Nakibuule et al, 2019). Ekstrak daun ketul juga terbukti mengandung flavonoid yang aktif menghambat pertumbuhan bakteri yang resisten terhadap obat antibiotika, seperti Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae dan Staphylococcus epidermidis yang resisten terhadap obat antibiotika (Nakibuule et al, 2019), (Silva et al, 2014) (Ezeonwumelu et al, 2017).…”

Section: Kandungan Kimia Daun Ketul Yang Berpotensi Sebagai Antibakteriunclassified

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Minireview: Formulasi Obat Kumur Ekstrak Daun Ketul (Bidens pilosa)

Meira

Iwansyah

Santoso

et al. 2021

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Abstract— Ketul (Bidens pilosa L) is weed plant that has antibacterial properties. The potential of this plant has not been developed yet in Indonesia. We conducted a literature study about this plant use for herbal mouthwash. The purposes of this study were to determine components of Ketul leaf with antibacterial activity, to know the extraction solvent, to determine the method for antibacterial activity, and to predict the characteristics and components of herbal mouthwash formula. The results showed that Ketul leaf contains tannins, cardiac glycosides, saponins, alkaloids, flavonoids, and terpenoids which could inhibit the growth of various bacteria, including Streptococcus mutans. Hence the mouthwash is predicted to have antibacterial activity. The safe extraction solvent widely used was 70-80% ethanol. The Ketul leaf extract has the potential to be applied in herbal mouthwash formula. Other characteristic can be adjusted to meet the requirements as herbal mouthwash, which are pH between 5-7, the viscosity value near water viscosity value (1cP), stable during storage, and color is brownish yellow. Some common additives were added in mouthwash to improve the flavors and taste, such as sorbitol, tween-80, peppermint oil, and sodium benzoate. Keywords: antibacterial activity, solvent, Streptococcus mutans, weed Abstrak— Ketul (Bidens pilosa L) merupakan tumbuhan gulma yang memiliki aktivitas antibakteri. Potensi tumbuhan ini belum banyak dikembangkan di Indonesia. Pada tulisan ini telah dilakukan kajian pustaka pemanfaatan Ketul untuk obat kumur herbal. Tujuan kajian ini adalah untuk mengetahui komponen ekstrak daun Ketul yang berkhasiat antibakteri, mengetahui pelarut ekstraksi, metode penentuan aktivitas antibakteri obat kumur, dan prediksi karakteristik dan komponen obat kumur herbal daun Ketul. Hasil penelusuran pustaka menunjukkan bahwa daun Ketul mengandung tannin, glikosida jantung, saponin, alkaloid, flavonoid, dan terpenoid, yang dapat menghambat pertumbuhan berbagai bakteri, termasuk Streptococcus mutans sehingga obat kumur kemungkinan memiliki aktivitas antibakteri. Pelarut aman yang banyak digunakan untuk ekstraksi komponen fitokimia tersebut adalah etanol 70-80%. Penentuan daya antibakteri dapat dilakukan menggunakan metode difusi agar atau pengenceran. Ekstrak daun Ketul berpotensi digunakan dalam formula obat kumur herbal. Selain potensi antibakterinya, karakteristik lainnya dapat diatur untuk memenuhi syarat formula obat kumur herbal yaitu pH berkisar 5-7, nilai viskositas mendekati nilai viskositas air (1cP), stabilitas dapat tetap terjaga selama penyimpanan dan kemungkinan obat kumur berwarna kuning kecoklatan. Beberapa bahan tambahan, seperti sorbitol, tween-80, peppermint oil, dan natrium benzoate, merupakan bahan tambahan yang aman dan umum digunakan untuk menambah cita rasa dan stabilitas formula obat kumur herbal ekstrak daun Ketul. Kata kunci: aktivitas antibakteri, gulma, pelarut, Streptococcus mutans

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Section: Pendahuluanunclassified

Section: Kandungan Kimia Daun Ketul Yang Berpotensi Sebagai Antibakteriunclassified

Minireview: Formulasi Obat Kumur Ekstrak Daun Ketul (Bidens pilosa)

Meira

Iwansyah

Santoso

et al. 2021

saintek

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Bidens pilosa Linn.: Beautiful Weed for the Healthy Mouth – A Mini Review

et al. 2023

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Bidens pilosa L. can be found everywhere in warm and humid regions. The plant has been used as a food and drink supplement, and as medicinal herbs for a long time by people from various places. The assortment of activities of B. pilosa in treating diseases gives a remarkable possibility to explore and develop its utilization for various medicinal purposes. In this mini-review, we explored the application of B. spilosa as herbal medicine for mouth health, specifically mouthwash. Until now, there is no information about the application of this plant for mouthwash. The use of alcohol, cetyl pyridinium, chlorhexidine, and triclosan as active ingredients in mouthwash can control plaque. However, the long-term use of these compounds may show side effects, for instance, changes in taste, and teeth and oral stains. Based on the result, it can be concluded that the B. spilosa plant contains diverse groups of compounds, such as polyacetylenes, flavonoids, and tannins, which are responsible for its various activities. The B. spilosa extracts are non-toxic and have potential active compounds in mouthwash formulation, due to their antimicrobial action against a wide range of microbes, particularly oral microbes and it has additional activities such as anti-inflammation, analgesic, and antioxidant.

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In vitro Antibacterial Efficacy of <i>Bidens pilosa</i>, <i>Ageratum conyzoides</i> and <i>Ocimum suave</i> Extracts against HIV/AIDS Patients’ Oral Bacteria in South-Western Uganda

Cited by 2 publications

References 27 publications

Minireview: Formulasi Obat Kumur Ekstrak Daun Ketul (Bidens pilosa)

Minireview: Formulasi Obat Kumur Ekstrak Daun Ketul (Bidens pilosa)

Bidens pilosa Linn.: Beautiful Weed for the Healthy Mouth – A Mini Review

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