In Vitro Antibacterial Phenolic Extracts from “Sugarbag” Pot-Honeys of Australian Stingless Bees (<i>Tetragonula carbonaria</i>)

Massaro, Carmelina Flavia; Shelley, Daniel; Heard, Tim A.; Brooks, Peter

doi:10.1021/jf5051848

Cited by 33 publications

(23 citation statements)

References 42 publications

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“…Other honey components, such as phenolic compounds originating from plant nectar or, in HD honeys, from excretions of plant-sucking insects, have been proposed as possible antibacterial agents. Several phenolics have so far been identified in honeys, including caffeic, p-coumaric and ellagic acids (Escuredo et al, 2012), diglycosyl flavonoids and terpenes (Massaro et al, 2014). While most of them have antibacterial activity, their contribution to the antibacterial properties of honey is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Anti-Quorum Sensing Activities of Selected Italian Honeys against Antibiotic-Resistant Pathogens

Fidaleo¹,

Lavecchia²,

Zuorro³

2015

OnLine Journal of Biological Sciences

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Three nectar honeys (eucalyptus, thyme and forest) and two honeydew honeys (fir and Metcalfa) from Italy were tested for their antibacterial activity against pathogens commonly associated with wound and burn infections, including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) and vancomycin-resistant Enterococcus faecalis (VREF). All honeys showed bactericidal activity against the microorganisms used, with honeydew honeys being the most effective. They also inhibited, in a dose-dependent manner, violacein production in Chromobacterium violaceum, thus demonstrating their ability to affect quorum sensing-regulated biofilm formation. Overall, the results obtained suggest that the honeys examined may have potential for developing natural antimicrobial compositions or dressings for the treatment of infected wounds or burns

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Section: Discussionmentioning

confidence: 99%

Antibacterial and Anti-Quorum Sensing Activities of Selected Italian Honeys against Antibiotic-Resistant Pathogens

Fidaleo¹,

Lavecchia²,

Zuorro³

2015

OnLine Journal of Biological Sciences

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“…Cytotoxicity studies of stingless bee honey broad spectrum antibacterial activity because honey can act against a wide range of bacteria that able to cause disease (Boorn et al, 2010;. Most of the studies of honey were performed on Staphylococcus aureus (Miorin et al, 2003;Demera et al, 2004;Temaru et al, 2007;Chanchao et al, 2009;Boorn et al, 2010;Chan-Rodriguez et al, 2012;Ilechie et al, 2012;Andualem et al, 2013;Ewnetu et al, 2013;Merces et al, 2013;Queiroz et al, 2013;Zainol et al, 2013;Nobre da Cruz et al, 2014;Massaro et al, 2014;Zamora et al, 2014) showed that it is the most susceptible tested pathogen to stingless bee honey. As we know, Staphylococcus aureus is a common pathogen found in human skin and can cause infection in the presence of a wound.…”

Section: Trigona Incisa Trigona Apicalis T Fuscobalteata T Fuscimentioning

confidence: 99%

“…Previous study showed that stingless bee honey can act as anti-inflammatory (Borsato et al, 2014), anticancer (Kustiawan et al, 2014;Yazan et al, 2016), antimicrobial (Miorin et al, 2003;Demera et al, 2004;Garedew et al, 2004;Temaru et al, 2007;Kimoto-Nira and Amano, 2008;Chanchao et al, 2009;Boorn et al, 2010;Rodríguez et al, 2012;Ilechie et al, 2012;Andualem, 2013;Ewnetu et al, 2013;Mercês et al, 2013;Queiroz et al, 2013;Zainol et al, 2013;Nobre da Cruz et al, 2014;Massaro et al, 2014;Zamora et al, 2014;Medeiros et al, 2016;De Sousa et al, 2016; and possessed antioxidant properties (Duarte et al, 2012;Almeida da Silva et al, 2013;De Sousa et al, 2016). However, the beneficial of stingless bee honey has been abandoned in modern medicine due to the paucity of systematic scientific studies for supporting its medical properties (Pe´rez et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…The color of the honey is usually clearer, liquid and has a sweet and sour taste (Roowi et al, 2012). The recent studies showed that the stingless bee honey has the potential to treat colorectal cancer (Yazan et al, 2016), anti-inflammatory (Borsato et al, 2014), antimicrobial (Zainol et al, 2013;Nobre da Cruz et al, 2014;Massaro et al, 2014;Medeiros et al, 2016;De Sousa et al, 2016; and has an antioxidant property (Almeida Da Silva et al, 2013;Duarte et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Stingless bee honey and its potential value: a systematic review

Yaacob

Rajab²,

Shahar³

et al. 2017

Food Res.

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Modern science has found that most traditional practice of using stingless bee honey has great potential as an added value in modern medicine and considered to have a higher medicinal value than other bee species. However, due to the relatively low output of honey compared to other honey so, focus on this honey is limited. Hence, this systematic review provides the updated result on the potential value of stingless bee honey as an antioxidant, anti-inflammatory, cytotoxicity and antimicrobial. The search strategy was developed in four databases (Scopus, Medline and Ovid, EMBASE and PubMed) with the search terms "("honey" and "Kelulut", "honey" and "stingless bee", "honey" and "Trigona", "honey" and "pot honey", and "honey" and "Melipon")". The merged data was assessed using PRISMA guidelines and after the duplicates were removed, 1271 articles were segregated. Afterwards, 1232 articles were eliminated because they do not meet the inclusion criteria and 39 articles were reevaluated again for eligibility. Finally, after the evaluation process, only 26 of the articles were chosen for this review. The data of 26 articles of stingless bee honey were deliberated based on antioxidant properties, anti-inflammatory, cytotoxicity and analysis of antimicrobial activity. Three articles reported on antioxidant properties, one article on anti-inflammatory analysis, two articles on cytotoxicity analysis, and twenty articles on analysis of antimicrobial activity. Based on the feasible affirmation from the literature, stingless bee honey has an antioxidant capacity that able to decrease the ROS. ROS able to lead a variety of health problems thus stingless bee honey can be a dietary supplement to overcome this problem.

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“…For example, compounds1,4,5,8,12,13,22,27,33,34,38,39, 49, 51 and 53 were shown to have antibacterial properties against Gram-positive and Gram-negative bacteria including Mycobacterium smegmatis, M. avium, Micrococcus luteus, Enterococcus faecalis, S. aureus and S. epidermidis, E. faecium, B. subtilis, P. aeruginosa, E. coli, P. reinekei and H. pylori. Compounds 3, 16 and 39 were shown to possess anti-inflammatory activity[14][15][16][17][18][19][20][21][22].Compounds 11,13,36,39, 48 and 54 possess antifungal activity where compounds 15 and 16 possess anti-oxidant activities[23][24][25][26][27]. Moreover, there was no biological activity reported for compounds2, 3, 7, 9, 26, 28, 29, 40, 42 and 47.…”

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confidence: 99%

Gut Bacteria of Water Monitor Lizard (Varanus salvator) Are a Potential Source of Antibacterial Compound(s)

et al. 2019

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For the past few decades, there has been limited progress in the development of novel antibacterials. Previously, we postulated that the gut microbiota of animals residing in polluted environments are a forthcoming supply of antibacterials. Among various species, the water monitor lizard is an interesting species that feeds on organic waste and the carcass of wild animals. Gut microbiota of the water monitor lizard were sequestered, identified and cultivated in RPMI-1640 to produce conditioned medium (CM). Next, the antimicrobial properties of CM were evaluated versus a selection of Gram-negative (Escherichia coli K1, Serratia marcescens, Pseudomonas aeruginosa, Salmonella enterica and Klebsiella pneumoniae) and Gram-positive bacteria (Streptococcus pyogenes, methicillin-resistant Staphylococcus aureus, and Bacillus cereus). CM were partially characterized by heat inactivation at 95°C for 10 min and tested against P. aeruginosa and S. pyogenes. CM were also tested against immortalized human keratinocytes (HaCaT) cells lines. The results demonstrated that gut microbiota isolated from water monitor lizard produced molecules with remarkable bactericidal activities. To determine the identity of the active molecules, CM were subjected to Liquid Chromatography-Mass Spectrometry. Several molecules were identified belonging to the classes of flavonoids, terpenoids, alkaloids, polyhydroxy alkaloids, polyacetylenes, bisphenols, amides, oxylipin and pyrazine derivatives with known broad-spectrum antimicrobial, anti-tumour, anti-oxidant, anti-inflammatory, and analgesic attributes. Furthermore, the detailed analysis of these molecules could lead us to develop effective therapeutic antibacterials.

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In Vitro Antibacterial Phenolic Extracts from “Sugarbag” Pot-Honeys of Australian Stingless Bees (Tetragonula carbonaria)

Cited by 33 publications

References 42 publications

Antibacterial and Anti-Quorum Sensing Activities of Selected Italian Honeys against Antibiotic-Resistant Pathogens

Antibacterial and Anti-Quorum Sensing Activities of Selected Italian Honeys against Antibiotic-Resistant Pathogens

Stingless bee honey and its potential value: a systematic review

Gut Bacteria of Water Monitor Lizard (Varanus salvator) Are a Potential Source of Antibacterial Compound(s)

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