In vitro anticancer active cis-Pt(II)-diiodido complexes containing 4-azaindoles

Anti-myeloma pro-apoptotic Pt(ii) diiodido complexes

“…The benzyl- and phenyl-based complexes 2–7 had higher lipophilicity than 1 containing methyl-substituted imidazole, and among them, it was phenyl-based complexes 4–7 , which showed higher lipophilicity than benzyl-analogues 2–3 . The obtained log P values of 1–7 are similar with highly anticancer active Pt( ii ) diiodido complexes with various azaindoles, 26,33 and indicated higher lipophilicity of the studied complexes as compared with cisplatin. 40…”

“…S1–S7†). 18,33,34 Additionally, the representative complexes 6 (97.8% at t R = 16.43 min) and 7 (96.3% at t R = 18.00 min) were analysed by reversed–phase high–performance liquid chromatography (RP–HPLC) coupled to mass spectrometry (electrospray ionization, ESI) (Fig. S8†).…”

“…The ESI+ mass spectra of 1-7 contained the peaks of the {[PtI 2 (L n ) 2 ] + X} + species with adequate m/z values and isotopic distribution; X = H + , Na + , K + or NH 18,33,34 Additionally, the representative complexes 6 (97.8% at t R = 16.43 min) and 7 (96.3% at t R = 18.00 min) were analysed by reversed-phase high-performance liquid chromatography (RP-HPLC) coupled to mass spectrometry (electrospray ionization, ESI) (Fig. S8 †).…”