In Vitro Anticancer Activity of Novel Co(II) and Ni(II) Complexes of Non-steroidal Anti-inflammatory Drug Niflumic Acid Against Human Breast Adenocarcinoma MCF-7 Cells

Çağlar, Sema; Altay, Ahmet; Kuzucu, Mehmet; Çağlar, Bülent

doi:10.1007/s12013-021-00984-z

Cited by 26 publications

(17 citation statements)

References 91 publications

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“…Mechanisms of apoptosis in cancer cells has been an attractive approach to combat with the prevention and progression of cancer incidence [83] . Caspase cascade has a critical role for the initiation of apoptosis in living cells, and two major pathways induce the activation of caspases, i. e., the mitochondrial pathway and death receptor pathway [84] .…”

Section: Resultsmentioning

confidence: 99%

“…[82] Mechanisms of apoptosis in cancer cells has been an attractive approach to combat with the prevention and progression of cancer incidence. [83] Caspase cascade has a critical role for the initiation of apoptosis in living cells, and two major pathways induce the activation of caspases, i. e., the mitochondrial pathway and death receptor pathway. [84] Initiation of caspase-activation mechanism through a stimuli including chemical drugs and other cellular stresses contributes to permeabilization of mitochondrial outer membranes and cause to release of cytochrome c from mitochondria to cytosol, in which cytochrome c together with Apaf-1, dATP, and procaspases assembles into a caspase-activating complex, catalyzing the cleavage of numerous critical proteins and finally terminated with apoptosome.…”

Section: Induction Mitochondrial Membrane Disruption Multi-caspase Ac...mentioning

confidence: 99%

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Phytochemical Analysis and Biological Evaluation of Hypericum linarioides Bosse: in Vitro and in Silico Studies

et al. 2022

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The aim of this study is to determine the phenolic composition of Hypericum linarioides Bosse, to assess its various biological properties, and finally to confirm the experimental data of enzyme inhibitions via docking studies. LC-MS/MS analysis performed over methanol extract (ME) revealed the presence of 27 phytochemicals. Antioxidant activity results indicated that ME had the strongest DPPH radical scavenging and ferric ion reducing capacity than water and hexane extracts. XTT assays revealed the strongest anti-proliferative activity of ME against MCF-7 and HT-29 cancer cells. Flow cytometry results also confirmed the notable apoptotic effect of ME on MCF-7 cells through mitochondria-dependent pathway. Enzyme activity results exhibited the most promising acetylcholinesterase and α-glycosidase inhibitory activities of the ME. Molecular docking calculations of α-glycosidase with the major compounds (1, 15, 17 and 19) indicated that 17 (isoquercitrin) had the best docking binding energy (À 10.92 kcal/mol) with appropriate binding interactions.

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Section: Resultsmentioning

confidence: 99%

Section: Induction Mitochondrial Membrane Disruption Multi-caspase Ac...mentioning

confidence: 99%

Phytochemical Analysis and Biological Evaluation of Hypericum linarioides Bosse: in Vitro and in Silico Studies

et al. 2022

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“…23 Recently, S. Caglar et al reported the in vitro anticancer activity of Co(II) and Ni(II) complexes of niflumic acid against human breast adenocarcinoma MCF-7 cells. 24 The effectiveness of metallodrugs is highly related to the choice of ligands. Thiosemicarbazide and its derivatives have several vital medicinal properties such as antifungal, anticonvulsant, antibacterial, and antitumor activities.…”

Section: Introductionmentioning

confidence: 99%

“…Also, the role of metal centers in exhibiting anticancer activities has not been explored much. 23,24 Most of the previous studies utilized complexes of the same metal for the mentioned purpose 11,12,14,15 or the effect on a single cell line is investigated. 16 Given the above, we report the synthesis, spectral, photoluminescence, and characterization of Mn(II), Co(II), and Ni(II) complexes of 4-phenyl-(2-furoyl)-thiosemicarbazide (Hpfth).…”

Section: Introductionmentioning

confidence: 99%

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In vitroandIn silicoanticancer activities of Mn(ii), Co(ii), and Ni(ii) complexes: synthesis, characterization, crystal structures, and DFT studies

et al. 2022

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Theoretical, in Vitro Antiproliferative, and in Silico Molecular Docking and Pharmacokinetics Studies of Heteroleptic Nickel(II) and Copper(II) Complexes of Thiosemicarbazone‐Based Ligands and Pefloxacin

Ahmed,

Mahendiran,

Bhat

et al. 2023

Chemistry & Biodiversity

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Twelve new heteroleptic nickel(II) and copper(II) complexes of the type [M(L1–6)(Pfx)2] (1–12), where L1–6=2‐benzylidenehydrazinecarbothioamide (L1), 2‐benzylidene‐N‐methylhydrazinecarbothioamide (L2), 2‐benzylidene‐N‐phenylhydrazinecarbothioamide (L3), 2‐(4‐methylbenzylidene)hydrazinecarbothioamide (L4), 2‐(4‐methylbenzylidene)‐N‐methylhydrazinecarbothioamide (L5) and 2‐(4‐methylbenzylidene)‐N‐phenylhydrazinecarbothioamide (L6), Pfx=pefloxacin and M=Ni(II) or Cu(II) have been synthesised, and their structures were confirmed by different spectral techniques. The spectral data and density functional theory (DFT) calculations supported the bonding of pefloxacin drug molecule via one of the carboxylate oxygen atoms and the pyridone oxygen atom, and the thiosemicarbazone ligand via the imine nitrogen and the thione sulfur atoms with the metal(II) ion, forming distorted octahedral geometry. In vitro antiproliferative activity of the synthesized complexes was evaluated against three human breast cancer (T47D, estrogen negative (MDA‐MB‐231) and estrogen positive (MCF‐7)) as well as non‐tumorigenic human breast epithelial (MCF‐10a) cell lines, which showed the higher activity for the copper(II) complexes. The interaction of the synthesized complexes with an oncogenic protein H‐ras (121 p) was explored by in silico molecular docking studies. Further, in silico pharmacokinetics and ADMET parameters were also analysed to predict the drug‐likeness as well as non‐toxic and non‐carcinogenic behavior, and safe oral administration of the complexes.

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In Vitro Anticancer Activity of Novel Co(II) and Ni(II) Complexes of Non-steroidal Anti-inflammatory Drug Niflumic Acid Against Human Breast Adenocarcinoma MCF-7 Cells

Cited by 26 publications

References 91 publications

Phytochemical Analysis and Biological Evaluation of Hypericum linarioides Bosse: in Vitro and in Silico Studies

Phytochemical Analysis and Biological Evaluation of Hypericum linarioides Bosse: in Vitro and in Silico Studies

In vitroandIn silicoanticancer activities of Mn(ii), Co(ii), and Ni(ii) complexes: synthesis, characterization, crystal structures, and DFT studies

Theoretical, in Vitro Antiproliferative, and in Silico Molecular Docking and Pharmacokinetics Studies of Heteroleptic Nickel(II) and Copper(II) Complexes of Thiosemicarbazone‐Based Ligands and Pefloxacin

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