In vitro anticancer and antioxidant activity studies on Drosera peltata J.E.Sm.

Balaji, Venkateshwarapuram Rengaswami; Asirvatham, Raju

doi:10.5455/spatula.20151123075443

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…They act like chelating agents that form bonds with metals and reduce the redox potential and stabilize the oxidized form of the metal ion. In the current study, HMERH demonstrated concentration-dependent stability, similar to that of ascorbic acid (Balaji et al, 2015).…”

Section: Discussionsupporting

confidence: 62%

In Vitro Antioxidant and Anticancer Activity of the Fruit Extract of Rivina Humilis L. (Red Pigeon Berry)

ASİRVATHAM>

George²

2023

J microb biotech food sci

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The purpose of this study was to evaluate the cytotoxic and antioxidant properties of a hydromethanolic extract of Rivina humilis L fruits extract (HMERH) on human cancer cell lines and various in vitro models. HMERH concentrations ranging from 5 to 400mg/ml were utilized in several assay methods such as hydroxyl radicals, DPPH, superoxide radical scavenging activity, metal chelating, and nitric oxide radical test, ABTS, and reducing power assay. All antioxidant assays employed ascorbic acid as the standard. Its short-term cytotoxicity on EAC and DLA cells was determined using the trypan blue dye exclusion method, as well as the lactate dehydrogenase (LDH) leakage assay and in vitro cytotoxicity on MEF-L929, DU-145, and PC-3 cells using the MTT assay. The total antioxidant potential was also determined using the phosphomolybdenum test. HMERH demonstrated considerable cytotoxicity against all cancer cell lines examined. The findings of the free radical scavenging activities demonstrated a concentration-dependent and antiradical activity caused by the reduction of ABTS, DPPH, NO, OH, and SO radicals to non-radical form. The findings reveal that antioxidants and cytotoxic agents have potent antioxidant and cytotoxic effects on cancer cell lines. Hence, this fruit extract has the potential to be a natural antioxidant and anticancer drug source, which could be valuable in the development of new anticancer therapies.

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Section: Discussionsupporting

confidence: 62%

In Vitro Antioxidant and Anticancer Activity of the Fruit Extract of Rivina Humilis L. (Red Pigeon Berry)

ASİRVATHAM>

George²

2023

J microb biotech food sci

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“…Cold decoration of D. indica is used to remove corn and these species are mentioned in the list of endangered medicinal plants (Reddy et al, 2001). Earlier in this report, the in vitro antioxidant and anticancer potential as well as the in vivo effect of D. peltata have been reported for different in vitro antioxidant and anticancer models (Balaji & Asirvatham, 2015). This study aimed to determine the ability of cells to recover and retain the antioxidant enzymes with the treatment of ethanol and an aqueous extract of 250 and 500 mg/kg D. peltata in Dalton Ascites Lymphoma (DAL) bearing mice.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant potential of Drosera peltata in Dalton Ascites Lymphoma (DAL) bearing mice

Asirvatham

Christina

2023

ijpbp

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Cancer is one of the prominent causes of death reported by World Health Organization (WHO). The purpose of this study was to measure the antioxidant status of animals treated with 250 and 500 mg/kg doses of ethanol and aqueous extract of Drosera peltata on Dalton Ascites Lymphoma (DAL) inoculated mice. A total of 70 mice were divided into 7 groups, each group with ten mice. The first group (negative control) received normal food and water for 14 days and was kept under normal conditions. The second group also received normal food and water for 14 days, which was used as a cancer (positive) control. The third group received 5-fluorouracil (20 mg/kg, i.p.) once a day for 14 days. The fourth and fifth group animals received 250 and 500 mg/kg of ethanol extracts of D. peltata (EEDP) whereas the sixth and seventh groups of mice received 250 and 500 mg/kg of aqueous extracts of D. peltata (AEDP), orally for 14 days. All the groups were inoculated with DAL (2 × 10 6 cells/mouse, i.p.) except group I, 24 hours before the commencement of the drug treatment. After the completion of treatment, blood was drawn retro-orbitally and the animals were sacrificed to isolate the liver, lungs, kidneys, and brain for observing tissue antioxidant status. The parameters analyzed were total protein (TP), catalase (CAT), malondialdehyde (MDA), superoxide dismutase (SOD), peroxidase (P), and glutathione (GSH) from the tissues apart, and the protein carbonyl content (PCC) also measured from the blood sample. Treatment with EEDP and AEDP significantly lowered the MDA levels from 23 to 10 mmol/ml in the blood, whereas from 28 to 4 nm/g in tissue isolates of the liver, lungs, kidneys, and brain. It also raised the TP, GSH, SOD, CAT, and P levels in the blood and in the tissue samples of the cancer cell line inoculated animals, where their levels were close to those observed in control (negative) group animals. The results proposed that both extracts of D. peltata ameliorated various tissue antioxidant levels in mice with DAL cancer lines comparable to the negative control.

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In vitro anticancer and antioxidant activity studies on Drosera peltata J.E.Sm.

Abstract: In vitro anticancer and antioxidant activity studies on Drosera peltata J.E.Sm.

Cited by 2 publications

References 5 publications

In Vitro Antioxidant and Anticancer Activity of the Fruit Extract of Rivina Humilis L. (Red Pigeon Berry)

In Vitro Antioxidant and Anticancer Activity of the Fruit Extract of Rivina Humilis L. (Red Pigeon Berry)

Antioxidant potential of Drosera peltata in Dalton Ascites Lymphoma (DAL) bearing mice

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