In vitro antidiabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme

Lekshmi, P; Arimboor, Ranjith; Nisha, V. M.; Menon, A. Nirmala; Raghu, K.

doi:10.1007/s13197-013-0953-7

Cited by 43 publications

(24 citation statements)

References 32 publications

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“…3) Índice de refracción. 4) Grados Brix: extracto seco disuelto en el solvente a 20,1 °C Extracto crudo 0,8144 ± 0,0005 (5) 160,31 ± 0,0069 1,3411 ± 0,0001 (5) 5,7167 ± 0,0289 (5) 5,9 ± 0,01 Reportes de investigaciones como Lekshmi et al (16) , sobre capacidad de captación de radicales de extractos de rizoma de cúrcuma en metanol por el método de DPPH, reportan valores de 53,7 ± 0,82 µg/mL y para la estándar curcumina IC50 es 6,90 ± 0,43 µg/mL. Comparados con nuestros resultados en etanol a 96%, los valores son IC50 6,89 ± 0,002 µg/mL para estándar curcumina y para extracto en etanol es 17,07 ± 0.004 µg/mL.…”

Section: Tabla 1 Resultados De Los Parámetros Fisicoquímicos Del Extunclassified

Caracterización físico-química y capacidad antioxidante de extractos del rizoma de Curcuma longa L.

Rafael¹,

Medina²,

Figueroa³

et al. 2019

Rev. per. med. integr.

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Objetivo. Determinar los parámetros físico-químicos y la capacidad antioxidante in vitro del extracto crudo y etanólico de Curcuma longa L. Materiales y métodos. Se obtuvieron dos extractos vegetales: crudo y en 96% de etanol. Se determinaron las características físico-químicas y la presencia de principales grupos de metabolitos mediante screening fitoquímico, asociados con actividad biológica. El contenido de polifenoles totales se determinó mediante el ensayo de Folin-Ciocalteu y la actividad antioxidante de los extractos se evaluó in vitro mediante el ensayo 2,2-difenil-1-picrilhidrazilo (DPPH) y 2,2-azinobis-[3 etilbenzotiazolin-6-sulfónico] (ABTS). Resultados. Los extractos crudo y etanólico de Curcuma longa L. presentaron una densidad relativa 0,8144 y 1,0536g/mL, respectivamente. Respecto al screening fitoquímico, se logró identificar algunos metabolitos en ambos extractos, destacando compuestos fenólicos, flavonoides, alcaloides y heterósidos. El contenido de fenoles totales fueron 252,05 y 296,43 (μg EAG/mg es) para los extractos crudo y etanólico. La capacidad antioxidante con el método DPPH tuvieron IC50 64,26 y 17,01 μg/mL y con el método de ABTS IC50 57,67 y 15,12 μg/mL para los extractos crudo y etanólico. La capacidad antioxidante equivalente a trolox (TEAC-DPPH) fueron 52,95 y 202,855 (μg trolox/mg es) para los extractos crudo y etanólico, la capacidad antioxidante equivalente a trolox (TEAC-ABTS) fueron 49,796 y 182,773 (μg trolox/mg es) para los extractos crudo y etanólico. Conclusiones. El extracto crudo, así como el extracto etanólico del rizoma de la Curcuma longa L. exhiben capacidad antioxidante que guardan correlación con el contenido de compuestos fenólicos.Palabras clave: Curcuma longa L.; rizoma; antioxidantes; fenoles (Fuente: DeCS)

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Section: Tabla 1 Resultados De Los Parámetros Fisicoquímicos Del Extunclassified

Caracterización físico-química y capacidad antioxidante de extractos del rizoma de Curcuma longa L.

Rafael¹,

Medina²,

Figueroa³

et al. 2019

Rev. per. med. integr.

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“…It has been recognized that the hypoglycemic effect of turmeric is mostly through the inhibition of α‐glucosidase and α‐amylase (Lekshmi, Arimboor, Nisha, Menon, & Raghu, 2014). However, our findings suggest that a decrease of glucose diffusion could also contribute to this biological effect.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning to carbohydrase enzymes inhibition, Lekshmi et al (2014) reported that turmeric extracts exert a significant inhibitory, even higher than acarbose. However, none of the supplements that we analyzed exhibited significant inhibition on α ‐amylase.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and antioxidant effects of five commercial turmeric ( Curcuma longa ) supplements

et al. 2020

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We evaluate the hypoglycemic and antioxidant effects of five commercial turmeric (Curcuma longa) supplements: (1) bulk samples, (2) turmeric root from India, (3) curcuma turmeric Pronat®, (4) turmeric & black pepper Swanson®, and (5) C3 complex® turmeric curcumin. Glucose diffusion and enzymatic starch digestion assays, using α‐amylase and α‐glucosidase, were performed. The antioxidant activity of turmeric supplements was measured through lipid peroxidation inhibition and the scavenging radical assay. A starch dose of 102 mg/Kg of body weight (equivalent to 1 g/day in humans) was used to perform the oral starch tolerance test (OSTT) in Wistar male rats. All turmeric supplements decreased glucose diffusion and α‐glucosidase enzyme activity, and inhibited lipid peroxidation. The rats that received bulk samples and CT showed significantly lower glucose levels than rats receiving acarbose and those of negative control group. Our results show that biological activities of turmeric supplements vary according to the commercial presentation. Practical applications The study results suggest that the hypoglycemic and antioxidant effects of five commercial turmeric supplements vary among them. The information provided would be useful to physicians and individuals using these supplements.

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“…Both plants Curcuma longa (CL) and Rauvolfia serpentina (RS), were previously reported as antihypertensive herbs (Soni et al, 2016) and possess ACE inhibition potential (Lekshmi et al, 2014;Ranjini et al, 2015). Therefore, in the present study the mixture of CL and RS (CL+RS) was evaluated as green ACE inhibitor to manage the angiotensin-II dependent hypertension in dogs, induced through Goldblatt 2 kidney 1 clip Reno vascular hypertension model (2K1C RVHM).…”

Section: Discussionmentioning

confidence: 99%

Effect of Herbal Mixture as Angiotensin Converting Enzyme Inhibitor in Angiotensin-II Dependent Hypertension

Farieha¹

2019

PVJ

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The effect of herbal mixture of Curcuma longa (CL) and Rauvolfia serpentina (RS) as green ACE inhibitors in Angiotensin-II dependent hypertension was evaluated by measuring the changes in ACE level in blood serum of hypertensive dogs. 2K1C Renovascular Hypertension Model (RVHM) was used to introduce hypertension in dogs. Substantial Hypertension was induced after seven days of renal artery ligation (RAL) with significant increase in the level of ACE in blood serum of spontaneously hypertensive dogs (SHD). Experimental dogs were divided into four groups among them RVH hypertension was induced in the dogs of three groups and fourth group was the normotensive dogs. Hypertensive dogs of one group left untreated while the other two groups treated with herbal mixture and standard drug (Captopril) respectively. The herbal mixture showed significant decrease in Systolic blood pressure (SBP) pressure, diastolic blood pressure (DBP), Pulse rate (PR), and serum ACE level of SHD as compared to Captopril. SBP, DBP and PR were also correlated with hematological parameters. Daily oral administration of herbal mixture resulted in a time-dependent blood pressure and ACE level reduction in SHD, with management of hypertension after nine days treatment. White blood cells (WBC), Lymphocyte (LYM), Mid-sized cells (MID), Granulocyte (GRA), platelet count (PLT), mean corpuscular volume (MPV), platelet distribution width (PDW) and platelet crit (PCT) showed highly significant (P<0.01) positive correlation with SBP, DBP and PR while (red blood cells) RBC showed significant (P<0.05) positive correlation only with SBP and PR. This study demonstrated that the combination of CL and RS effectively reduced blood pressure and heart rate of SHD and this antihypertensive effect is probably due to the reduction of ACE level in blood serum.To Cite This Article: Farieha, Jahan N, Rehman KU and Ali S, 2019. Effect of herbal mixture as Angiotensin converting enzyme inhibitor in Angiotensin-II dependent hypertension. Pak Vet J, 39(1): 25-30. http://dx.

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In vitro antidiabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme

Cited by 43 publications

References 32 publications

Caracterización físico-química y capacidad antioxidante de extractos del rizoma de Curcuma longa L.

Caracterización físico-química y capacidad antioxidante de extractos del rizoma de Curcuma longa L.

Hypoglycemic and antioxidant effects of five commercial turmeric ( Curcuma longa ) supplements

Effect of Herbal Mixture as Angiotensin Converting Enzyme Inhibitor in Angiotensin-II Dependent Hypertension

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