In vitro antifungal activity of heterocyclic organoboron compounds against Trichophyton mentagrophytes and Microsporum canis obtained from clinical isolates

Pir, Meryem; Budak, Faik; Metiner, Kemal

doi:10.1007/s42770-022-00777-3

Cited by 2 publications

(2 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The substituted heterocyclic dioxaborepines and oxadiazaboroles (codes of compounds in references/codes of compounds in current study: 4 a-4 m [26] /d4 a-d4 m, 2 a-2 c [23] /d4 n-d4 p, 4 a-4 r [25] /o4 a-o4 r and 7 a-7 s [25] /o7 a-o7 s) with significant antimicrobial activities [23,25,26,48] those used in our study are organoboron compounds whose effects have not been examined against SARS-CoV-2 before. In addition to defining the ADMET properties of related compounds, molecular docking studies were performed to obtain binding poses and properties of these ligands in binding sites of SARS-CoV-2 Spike RBD/ACE2 complex and M PRO proteins.…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking Studies of Boron‐Containing Compounds as Dual Inhibitors of SARS‐Cov‐2 Spike Receptor Binding Domain/ACE2 Complex and Main Protease and ADMET Investigations

Ercan,

Pir

2023

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

The severe acute respiratory syndrome SARS‐CoV‐2 is the causative agent of COVID‐19. Preventing binding of SARS‐CoV‐2 Spike glycoprotein to human ACE2 enzyme and inhibition of MPRO enzyme are still attractive drug targets for treatment of COVID‐19 infection. Boron atom‐containing compounds show anticancer, antibacterial, antiviral, antifungal, antiparasitic, anti‐inflammatory, antituberculosis, anti‐dermatophytic and anti‐fertility activities. In the current study, the ADMET properties of ligands were calculated by the aim of SwissADME and pkCSM pharmacokinetics web tools. The results revealed that the ligands meet drug‐likeness properties. Furthermore, we have performed molecular docking study of boron containing dioxaborepine and oxadiazaborole derivatives to investigate binding properties of ligands against SARS‐CoV‐2 Spike glycoprotein/ACE2 complex and inhibition of MPRO enzyme. Through the ligands a derivative of dioxaborepine showed best binding score against SARS‐CoV‐2 Spike glycoprotein/ACE2 complex with a binding score of −8.93 kcal/mol and a oxadiazaborole derivative exhibited a binding score value of −8.36 kcal which is the best binding ligand to the MPRO enzyme binding site. The analysis of binding poses of ligands and ligand‐residue interactions of the systems revealed that dioxaborepines and oxadiazaboroles could have block binding of Spike glycoprotein to human ACE2 enzyme and could have inhibition effects on MPRO enzyme.

show abstract

Section: Introductionmentioning

confidence: 99%

Molecular Docking Studies of Boron‐Containing Compounds as Dual Inhibitors of SARS‐Cov‐2 Spike Receptor Binding Domain/ACE2 Complex and Main Protease and ADMET Investigations

Ercan,

Pir

2023

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

show abstract

“…Trichophyton spp., Microsporum spp., and Epidermophyton spp. are three genera of Dermatophytes which are filamentous keratinophilic and keratinolytic fungi that are highly related to one another and have evolved to colonize and invade the keratinized tissues of both animals and people [1]. Dermatophytes can be categorized ecologically as geophilic, zoophilic, or anthropophilic depending on where they get their keratin from.…”

Section: Introductionmentioning

confidence: 99%

Super Glue Production by Dermatophytes: Review

Yassein¹

2023

ijcsrr

View full text Add to dashboard Cite

Dermatophytosis can be caused on by the invasion and infection of keratinized tissues in people and animals via a group of filamentous fungus known as dermatophytes. About a quarter of the world’s population is affected by it which is one of the most prevalent superficial fungal diseases. Some of these fungi have the capacity to develop complex 3-D biofilm structures, or “biofilm,” which are distinguished by the creation of extracellular polymeric molecules and a heightened drug resistance. The assessment of biofilm now relies on a variety of different methods, which frequently results in various evaluations of the microbial strains’ capacity to create biofilms. It has only recently been discovered the architecture and growth features of dermatophytic biofilms (Trichophyton spp., Microsporum spp.). Additionally, the structural complexity and lack of research on filamentous fungal biofilms make therapy challenging. Therefore, there is a demand for newer antifungals or methods for treating resistant dermatophytosis to offer an efficient, original, and safe substitute to current treatments. Therefore, this review highlighted on the significance, characterization and evaluation of biofilm that produced from dermatophytes.

show abstract

In vitro antifungal activity of heterocyclic organoboron compounds against Trichophyton mentagrophytes and Microsporum canis obtained from clinical isolates

Cited by 2 publications

References 56 publications

Molecular Docking Studies of Boron‐Containing Compounds as Dual Inhibitors of SARS‐Cov‐2 Spike Receptor Binding Domain/ACE2 Complex and Main Protease and ADMET Investigations

Molecular Docking Studies of Boron‐Containing Compounds as Dual Inhibitors of SARS‐Cov‐2 Spike Receptor Binding Domain/ACE2 Complex and Main Protease and ADMET Investigations

Super Glue Production by Dermatophytes: Review

Contact Info

Product

Resources

About