In Vitro Antifungal Activity of Ankaferd Blood Stopper Against Candida albicans

Abstract

The various tests were carried out to investigate antifungal effects of ABS on Candida, but none were found.

Ankaferd blood stopper: A novel hemostatic agent with unique antimicrobial, antineoplastic and regenerative properties

“…Pellati et al (2009) and Motsei et al (2003) also demonstrated that 18-beta glycyrrhetinic acid, the key components of ABS, is known to possess a strong antifungal effect on the Candida albicans [36,37]. This property can be utilized for preparing various antifungal mouthwashes for the treatment of oral candidiasis and other fungal infections [47][48][49][50][51][52]. Therefore ABS should be tried as an antiplaque and anti-gingivitis agent for the treatment of gingivitis, periodontitis, periapical, periodontal abscess and postoperative infections following periodontal surgery.…”

“…ABS is also known to inhibit the growth of various yeast and filamentous fungi. Ciftci et al (2011) assessed the antifungal effect of ABS using a good diffusion agar test and found that ABS has a high antifungal effect against Zygosaccharomyces bailii, Candida albicans, Aspergillus flavus, and Aspergillus parasiticus [47]. Pellati et al (2009) and Motsei et al (2003) also demonstrated that 18-beta glycyrrhetinic acid, the key components of ABS, is known to possess a strong antifungal effect on the Candida albicans [36,37].…”

“…ABS is known to enhance hard and soft tissues healing as it also increases the tissue oxygenation along with superior regenerative, antioxidant and pro-angiogenic properties [46,[47][48][49]. Moreover, ABS can be considered as a better option in inducing regenerating epithelium than epinephrine.…”

“…The intravesical administration of ABS is as efficacious as epinephrine in terms of congestion, edema, necrosis, and ulceration. This properties of ABS can be utilized in the treatment of periodontitis-induced osseous defects, periodontal plastic surgery for root coverage, aesthetic surgery for papilla regeneration and healing of orofacial burns [46][47][48][49]54]. Bulut E et al (2014) analyzed and compared the effects of ABS and routine antibiotic prophylaxis on early healing of periodontal osseous defects in diabetic rats and non-diabetic rats by histopathology and stereological examination [50].…”

“…There was a significant increase in the VEGF concentration when ABS was used along with bone graft as compared to bone graft alone. The VEGF enhance regeneration of periodontal tissues along with improved wound healing, angiogenesis and reduced gingival inflammation at the defect site [45,47,48,[52][53][54][55]. The ABS induced release of VEGF also increases the regenerative potential of the bone graft and promotes superior soft tissue healing, clinical attachment gain and reduce the incidence of post-operative gingival recession.…”