In vitro antifungal drug susceptibilities of dermatophytes microconidia and arthroconidia

Abstract

The difference in the susceptibility between microconidia and arthroconidia depends on the drug and on the strain, and may be one of the causes of therapeutic failure. Also, the level of resistance to the antibiotic hygromycin B presented by microconidia of these isolates will allow the use of hygromycin resistance as a dominant marker in fungal transformation procedures in future studies of gene function.

In vitro susceptibilities of Neoscytalidium spp. sequence types to antifungal agents and antimicrobial photodynamic treatment with phenothiazinium photosensitizers

“…hyalinum. The ability to kill ungerminated conidia is a positive aspect of APDT, since conidial tolerance to currently-used antifungal agents is frequently pointed out as one of the causes of therapeutic failure and recurrence of the infections [58][59][60]. Arthroconidia of N. dimidiatum isolates were more tolerant to APDT with all the four phenothiazinium PS than the hyaline isolates (see Table 5).…”

Update on terbinafine with a focus on dermatophytoses

“…Both arthroconidia and microconidia of selected Trichophyton species demonstrate the same susceptibility profi le to terbinafi ne in vitro. 26 In addition to diminished susceptibility, non-dermatophyte species of fungi demonstrate resistance mechanisms not observed in the dermatophytes. Under the selective pressure of terbinafi ne exposure, an increase in the expression of energy-dependent effl ux transporters can be observed in yeast; 27 however, the expression level of orthologous transporters remains unchanged in dermatophytes.…”

Evaluation of Antifungal Effect of Silver Nanoparticles Against Microsporum canis, Trichophyton mentagrophytes and Microsporum gypseum

“…Dermatophytosis is caused by the keratinophylic fungus called dermatophytes (23). Transmissibility from infected humans or animals to human is one important public health problem caused by dermatophyte species (24).…”