In Vitro Antimalarial and Cytotoxic Activities of Sauropus androgynus Leaves Extracts

doi:10.26538/tjnpr/v4i9.11

Cited by 3 publications

(1 citation statement)

References 29 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Malaria is a major disease that affects tropical countries, especially developing countries. Antimalarial activity of S. androgynus was explored by Mahardiani et al [ 216 ] and reported significant cytotoxicity against Plasmodium falciparum in the Huh7 liver cell lines. Zou et al [ 44 ] revealed the antimalarial activity of another species viz.…”

Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

2022

View full text Add to dashboard Cite

Various plants form the basis of multiple traditional ethnic cuisines and ethnomedicinal practices across the globe. The ethnic cuisines cater to the nutritional, dietary and medicinal requirements of the tribal and rural communities even today. Using literature from various scholarly databases, this study was conducted to consolidate a comprehensive review on the use of Sauropus androgynus (L.) Merr. in various traditional ethnic cuisines and ethnomedicinal preparations across the globe. The survey shows that it is used in multiple ethnic cuisines and is variously known in different countries and among the communities. Further, it possesses multiple nutritional and ethnomedicinal properties. Considering its importance in ethnic foods and ethnomedicinal preparations, it is important to investigate the nutritional composition, phytochemical constitution and pharmacological basis of ethnomedicinal uses. Therefore, we further compiled this information and found that it is a rich source of both micro- and macronutrients and packed with several bioactive compounds. Survey of pharmacological studies on its traditional medicinal uses supports its ethnomedicinal properties. Despite its importance in traditional food and ethnomedicinal systems, it remains underexplored. Limited information on the toxicity of its various extracts shows that further studies should be conducted to understand its safety aspects. Further clinical studies to prospect possible drug candidates from it should be attempted.

show abstract

Section: Pharmacology Of Sauropus Androgynusmentioning

confidence: 99%

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

2022

View full text Add to dashboard Cite

show abstract

Five new quinoline alkaloids from Sauropus hirsutus Beille and their cytotoxicity

Sombatsri

Sribuhom

Pornchoo

et al. 2021

Natural Product Research

View full text Add to dashboard Cite

Chemical investigation of the whole plant of Sauropus hirsutus Beille led to the isolation of eight quinolines and two known flavonoids. Furthermore, five quinolines were new, two were reported in plant for the first time and one was known. Cytotoxicity evaluation against cholangiocarcinoma, KKU-M156, showed that the most active compound was 4-hydroxy-6methoxy-7,8-methylenedioxyquinaldine (IC50 20.54 ± 6.82 M) which was a little more active than the cisplatin standard (IC50 24.39 ± 1.14 M).

show abstract

Antimalarial Activity of Extract and Fractions of Sauropus androgynus (L.) Merr.

et al. 2022

View full text Add to dashboard Cite

Sauropus androgynus (L.) Merr., in the Indonesian local name known as “Katuk,” is a tropical shrub plant of the family Euphorbiaceae. Based on genus and chemotaxonomic approaches, as well as in vitro testing of Plasmodium falciparum, leaves of S. androgynus are presumed to have an active compound content as an antimalarial. The current study aims to investigate the antimalarial activity of 96% ethanol extract and fractions of S. androgynus leaves. The ethanolic extract was fractionated using the vacuum liquid chromatography (VLC) method with three solvents of different polarities (n-hexane, chloroform, and 96% ethanol). The fraction obtained was then evaluated for antimalarial activity against P. falciparum 3D7 strain. The ethanolic extract was evaluated for antimalarial suppressive and prophylactic activity against P. berghei-infected mice, as well as inhibitory activity against the heme detoxification process in vitro. Fractionation of ethanolic extract resulted in seven combined fractions, with the most active fraction being FV (50% inhibitory concentration (IC50) = 2.042 µg/mL). The ethanolic extract showed good parasitic suppressive (therapeutic) activity with a median effective dose (ED50) value of 15.35 mg/kg body weight. In a prophylactic test, ethanolic extract showed parasite growth inhibitory activity of 67.74 ± 9.21% after the administration of 400 mg/kg body weight for 4 days before infection, and 65.30 ± 10.44% after the administration of 200 mg/kg body weight for 8 consecutive days (4 days before and after infection). The ethanolic extract also showed an effect in inhibiting the formation of β-hematin of about 26.87–79.36% at a concentration of 0.1–4 mg/mL and an IC50 value of 0.479 mg/mL. The S. androgynus leaves were shown to have antimalarial activity in vitro and in vivo, where ethanolic extract were more active compared with the fraction obtained. The antimalarial properties of the extract showed a higher suppressive activity than prophylactic activity.

show abstract

In Vitro Antimalarial and Cytotoxic Activities of Sauropus androgynus Leaves Extracts

Cited by 3 publications

References 29 publications

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

Five new quinoline alkaloids from Sauropus hirsutus Beille and their cytotoxicity

Antimalarial Activity of Extract and Fractions of Sauropus androgynus (L.) Merr.

Contact Info

Product

Resources

About