In vitro antimicrobial activity of the essential oil from Vanillosmopsis arborea Barker (Asteraceae) and its major constituent, α-bisabolol

Rodrigues, Fabíola Fernandes Galvão; Colares, Aracélio Viana; Nonato, Carla de Fátima Alves; Galvão-Rodrigues, Fábio F.; Mota, Magaly Lima; Braga, Maria Flaviana Bezerra Morais; Costa, José Galberto Martins da

doi:10.1016/j.micpath.2018.09.024

Cited by 23 publications

(14 citation statements)

References 35 publications

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“…Rodriguésia 72: e00432020. 2021 compound was also able to enhance antifungal activity of fluconazole against C. albicans and C. tropicalis strains (Rodrigues et al 2018). Futhermore, the antifungal activity of essential oil obtained from leaves of Piper claussenianum (miq.)…”

Section: Discussionmentioning

confidence: 97%

Casearia sylvestris essential oil and its fractions inhibit Candida albicans ABC transporters related to multidrug resistance (MDR)

et al. 2021

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ABC transporters constitute a superfamily of transmembrane proteins that act mediating the translocation of several substrates across the membrane, using the energy of ATP hydrolysis. This mechanism of unrelated substrates efflux (multidrug resistance) has been associated with several diseases and it is a problem in chemotherapy efficacy. Nowadays, approximately 25% of the prescription drugs in the world are derived from plants. Casearia sylvestris is commonly found in the Americas and different parts of this plant are popularly used to treat several diseases. Previous studies have also confirmed the biological activities of C. sylvestris, such as anti-tumor, anti-leishmania, and antifungal properties. Then, the propose of this study was demonstrate that fraction 1-6 of C. sylvestris, essential oil, was able to reverse the fluconazole resistance phenotype in the Saccharomyces cerevisiae model mediated by the heterologous protein CaCdr2p from Candida albicans. The MIC value of fraction 1-6 combined with fluconazole in the checkerboard assay decreased approximately 4-fold, suggesting a synergistic effect. In addition, fraction 1-6 increased intracellular rhodamine 6G accumulation from 17% to 49% in the presence of glucose. Data indicate that C. sylvestris fraction 1-6 is a potential reverser of the fluconazole resistance phenotype.

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Section: Discussionmentioning

confidence: 97%

Casearia sylvestris essential oil and its fractions inhibit Candida albicans ABC transporters related to multidrug resistance (MDR)

et al. 2021

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“…It exhibited significant antileishmanial activity against promastigotes with IC 50 values of 8.07 μg/mL (24 h) and 4.26 μg/mL (48 h) during the in vitro studies and did not lead to the appearance of toxicity or side effects after the administration of (−)-α-bisabolol in healthy and infected hamsters [ 7 , 8 ]. The biological studies also revealed that 1 exhibited anti-irritant, antibacterial, antinociceptive, gastroprotective, cardioprotective and anticancer properties [ 4 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…(−)-α-Bisabolol is a highly lipophilic compound that is almost insoluble in water, which limits its pharmaceutical applications [ 9 , 28 ]. In addition, its metabolic fate has not been extensively investigated in the previously reported metabolism studies of (−)-α-bisabolol.…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of (−)-α-Bisabolol by Absidia coerulea

2022

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(−)-α-Bisabolol, a bioactive monocyclic sesquiterpene alcohol, has been used in pharmaceutical and cosmetic products with anti-inflammatory, antibacterial and skin-caring properties. However, the poor water solubility of (−)-α-bisabolol limits its pharmaceutical applications. It has been recognized that microbial transformation is a very useful approach to generate more polar metabolites. Fifteen microorganisms were screened for their ability to metabolize (−)-α-bisabolol in order to obtain its more polar derivatives, and the filamentous fungus Absidia coerulea was selected for scale-up fermentation. Seven new and four known metabolites were obtained from biotransformation of (−)-α-bisabolol (1), and all the metabolites exhibited higher aqueous solubility than that of the parent compound 1. The structures of newly formed metabolites were established as (1R,5R,7S)- and (1R,5S,7S)-5-hydroxy-α-bisabolol (2 and 3), (1R,5R,7S,10S)-5-hydroxybisabolol oxide B (4), (1R,7S,10S)-1-hydroxybisabolol oxide B (5), 12-hydroxy-α-bisabolol (7), (1S,3R,4S,7S)- and (1S,3S,4S,7S)-3,4-dihydroxy-α-bisabolol (8 and 10) on the basis of spectroscopic analyses. These compounds could also be used as reference standards for the detection and identification of the metabolic products of 1 in the mammalian system.

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“…Bip. (Candeia), Vanillosmopsis arborea Barker (candeeiro) and Matricaria chamomilla L. Rausch (camomilla), belonging to the Asteraceae family, which may also be isolated from other aromatic plant varieties [15,16]. Following extraction, α-Bisabolol varies from colorless to light yellow, having a slightly viscous appearance and strong floral aroma.…”

Section: Introductionmentioning

confidence: 99%

Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus Strains

et al. 2020

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Efflux pumps are proteins present in the plasma membrane of bacteria, which transport antibiotics and other compounds into the extracellular medium, conferring resistance. The discovery of natural efflux pump inhibitors is a promising alternative. α-Bisabolol is a sesquiterpene isolated from several plants such as Matricaria chamomilla L. and has important properties such as antibacterial and anti-inflammatory activity. Currently, the formation of inclusion complexes with β-Cyclodextrin has been used for improving the physicochemical characteristics of the host molecule. This study evaluated the effect of α-Bisabolol, in isolation and in complexation with β-Cyclodextrin, as TetK and NorA efflux pump inhibitors in Staphylococcus aureus strains. The minimum inhibitory concentration (MIC) was determined. Subsequently, inhibitory activity over the pumps was observed by an MIC reduction for the antibiotics, by using subinhibitory concentrations (MIC/8) in combination with tetracycline and norfloxacin. The MIC of the compounds was ≥1024 μg/mL. α-Bisabolol potentiated the action of tetracycline and reduced the MIC of norfloxacin to a clinically relevant concentration. The complexed substance showed synergism however, the effect of the isolated α-Bisabolol was superior to the complex. These results indicate α-Bisabolol is a potential substance to be used as an efflux pump inhibitor.

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In vitro antimicrobial activity of the essential oil from Vanillosmopsis arborea Barker (Asteraceae) and its major constituent, α-bisabolol

Cited by 23 publications

References 35 publications

Casearia sylvestris essential oil and its fractions inhibit Candida albicans ABC transporters related to multidrug resistance (MDR)

Casearia sylvestris essential oil and its fractions inhibit Candida albicans ABC transporters related to multidrug resistance (MDR)

Biotransformation of (−)-α-Bisabolol by Absidia coerulea

Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus Strains

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