The genus
Streptomyces
demonstrates enormous promise in promoting plant growth and protecting plants against various pathogens. Single and consortium treatments of two selected
Streptomyces
strains (
Streptomyces shenzhenensis
TKSC3 and
Streptomyces
sp. SS8) were evaluated for their growth-promoting potential on rice, and biocontrol efficiency through induced systemic resistance (ISR) mediation against
Xanthomonas oryzae
pv.
oryzicola
(
Xoc
), the causal agent of rice bacterial leaf streak (BLS) disease. Seed bacterization by
Streptomyces
strains improved seed germination and vigor, relative to the untreated seed. Under greenhouse conditions, seed bacterization with consortium treatment TKSC3 + SS8 increased seed germination, root length, and dry weight by 20%, 23%, and 33%, respectively. Single and consortium
Streptomyces
treatments also successfully suppressed
Xoc
infection. The result was consistent with defense-related enzyme quantification wherein single and consortium
Streptomyces
treatments increased peroxidase (POX), polyphenol oxidase, phenylalanine ammonia-lyase, and β,1–3 glucanase (GLU) accumulation compared to untreated plant. Within all
Streptomyces
treatments, consortium treatment TKSC3 + SS8 showed the highest disease suppression efficiency (81.02%) and the lowest area under the disease progress curve value (95.79), making it the best to control BLS disease. Consortium treatment TKSC3 + SS8 induced the highest POX and GLU enzyme activities at 114.32 μmol/min/mg protein and 260.32 abs/min/mg protein, respectively, with both enzymes responsible for plant cell wall reinforcement and resistant interaction. Our results revealed that in addition to promoting plant growth, these
Streptomyces
strains also mediated ISR in rice plants, thereby, ensuring protection from BLS disease.