In Vitro Antimicrobial Efficacy of Riboflavin and Ultraviolet Light on
 Staphylococcus aureus
 , Methicillin-resistant
 Staphylococcus aureus
 , and
 Pseudomonas aeruginosa

Schrier, Amilia; Greebel, Gennifer; Attia, Hosam; Trokel, Stephen L.; Smith, Edward F.

doi:10.3928/1081597x-20090813-07

Cited by 74 publications

(69 citation statements)

References 20 publications

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“…The proteolytic enzymatic activity is the cause of clinical corneal melting during and following corneal infections. In vitro studies have demonstrated a good bactericidal effect of combined riboflavin and UVA on several bacterial species which are known pathogens in bacterial keratitis [159,160]. The effects on fungal and acanthamoebic activity in vitro were less favorable, showing no significant effect on viability [161,162].…”

Section: Other Indications For Riboflavin-uvx Collagen CXLmentioning

confidence: 99%

Corneal Collagen Crosslinking: A Systematic Review

Sorkin

Varssano²

2014

Ophthalmologica

166

122

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Keratoconus (KCN) is an ectatic disorder with progressive corneal thinning and a clinical picture of corneal protrusion, progressive irregular astigmatism, corneal fibrosis and visual deterioration. Other ectatic corneal disorders include: post-LASIK ectasia (PLE) and pellucid marginal degeneration (PMD). Corneal crosslinking (CXL) is a procedure whereby riboflavin sensitization with ultraviolet A radiation induces stromal crosslinks. This alters corneal biomechanics, causing an increase in corneal stiffness. In recent years, CXL has been an established treatment for the arrest of KCN, PLE and PMD progression. CXL has also been shown to be effective in the treatment of corneal infections, chemical burns, bullous keratopathy and other forms of corneal edema. This is a current review of CXL - its biomechanical principles, the evolution of CXL protocols in the past, present and future, indications for treatment, treatment efficacy and safety.

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Section: Other Indications For Riboflavin-uvx Collagen CXLmentioning

confidence: 99%

Corneal Collagen Crosslinking: A Systematic Review

Sorkin

Varssano²

2014

Ophthalmologica

166

122

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“…In another in vitro study performed by Schrier A et al, the antibacterial action of riboflavin alone, UV light alone and the combination of riboflavin and UV light has been assessed on S. aureus, MRSA and P. aeruginosa. According to their results, no bacterial death was seen in plates of riboflavin alone and all S. aureus and MRSA plates exposed to UV light alone; however, significant bacterial death was observed in all plates exposed to the combination of riboflavin and UV light [19].…”

Section: Discussionmentioning

confidence: 99%

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis

Khalili

Jahadi

Karimi

et al. 2017

JCDR

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Introduction: Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis.Aim: Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (HSV) keratitis. Materials and Methods:In this prospective interventional study, eight patients with diagnosis of infectious keratitis who were referred to Khalili Hospital eye emergency room, between 2014 and 2015 were included in the study. There were six patients with bacterial keratitis and two patients with HSV keratitis; they were resistant to conventional treatment and underwent CXL. Response to the treatment was considered as good if rapid epithelialization and rapid decrease in stromal infiltration occurred.Results: Microbial culture in the bacterial keratitis group showed coagulase negative Staphylococcus in two patients, Staphylococcus aureus in one patient, mixed infection in one patient and Pseudomonas aeruginosa in two patients. Good response and rapid epithelialization and resolution of stromal infiltration were seen in the four out of six eyes. Two patients showed no response and underwent penetrating keratoplasty for eradication of infection. Furthermore, one patient showed a good response to CXL in the HSV keratitis group and another patient had a relative response but recurrence occurred.Conclusion: Although, CXL seems promising in the treatment of patients with refractory bacterial keratitis, but in some cases, it is ineffective. CXL may be an alternative treatment for refractory cases of HSV keratitis but recurrence is possible.

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“…Антибактериальный эффект взаимодействия УФА и рибофлавина был доказан двумя независи-мыми друг от друга группами исследователей на культуре бактерий, выращенных на агаровой среде в чашках Петри [19,20]. Кроме того, в ходе этого ис-следования ряд бактериальных штаммов, относя-щихся к обычным возбудителям микробного кера-тита, был уничтожен при облучении рибофлавина ультрафиолетом.…”

Section: кросслинкингunclassified

“…[19] и группы A. Schrier и соавт. [20] стали появляться работы о применении метода КРЛ в лечении тяжелых бакте-риальных кератитов, включая бактериальные кера-титы с изъязвлением, грибковые и акантамебные кератиты [25][26][27][28][29][30].…”

Section: кросслинкингunclassified

Modern treatments for purulent corneal ulcers

Kasparova¹

2016

Vestn. oftal'mol.

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In Vitro Antimicrobial Efficacy of Riboflavin and Ultraviolet Light on Staphylococcus aureus , Methicillin-resistant Staphylococcus aureus , and Pseudomonas aeruginosa

Abstract: Riboflavin in combination with UV light is an effective modality to eradicate the bacteria S aureus, MRSA, and P aeruginosa.

Cited by 74 publications

References 20 publications

Corneal Collagen Crosslinking: A Systematic Review

Corneal Collagen Crosslinking: A Systematic Review

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis

Modern treatments for purulent corneal ulcers

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