In vitro antioxidant activities of copper mixed oxide (CuO/Cu2O) nanoparticles produced from the leaves of Phoenix dactylifera L

Abstract

Biosynthesis of antioxidant nanoparticles using plant extracts is a simple, rapid, environmentally friendly, and cost-effective approach. In this study, in vitro antioxidant copper mixed oxide nanoparticles (CuO/Cu2O) were prepared from the alcoholic extract of Phoenix Dactylifera L. and different aqueous concentrations of CuSO4·5H2O. The composition, crystallinity, morphology, and particle size of CuO/Cu2O NPs were tuned by increasing the CuSO4·5H2O concentration from 4 to 10 mM. Ultraviolet–visible (UV–Vis) and Fourier-transform infrared (FTIR) spectroscopy confirmed the reduction of CuSO4·5H2O and the formation of the CuO/Cu2O NPs. X-ray diffraction (XRD) confirmed the crystalline nature of the CuO/Cu2O NPs with a crystallite size varying from 18 to 35 nm. Scanning electron micrographs (SEM) showed that the CuO/Cu2O NPs have a spherical morphology with particle sizes ranging from 25 to 100 nm. The best antioxidant CuO/Cu2O NPs have a phase ratio of about 1:1 CuO/Cu2O with a half-maximal inhibitory concentration (IC50) of 0.39 mg/ml, an iron-containing reducing antioxidant power (FRAP) of 432 mg EFeSO4/100 mg NPs, and a total antioxidant capacity (TAC) of 65 mg EAA/gNPs. The results suggest that the synthesized CuO/Cu2O NPs are excellent antioxidants for therapeutic applications. Graphical abstract

Plant mediated synthesis of flower-like Cu2O microbeads from Artimisia campestris L. extract for the catalyzed synthesis of 1,4-disubstituted 1,2,3-triazole derivatives

“…The bandgap of CuO is smaller, typically around 1.3–1.7 eV ( Jeong et al, 2022 ). The absorption and bandgap energy values can vary slightly based on factors such as crystal structure, size of the particles, and specific experimental conditions ( Djamila et al, 2022 ).…”

Green synthesis of CuO nanoparticles using Ligustrum lucidum extract, and the antioxidant and antifungal evaluation

“…FTIR spectrum (figure 3) of the plant extract displayed several absorption bands that corresponded to the functional groups of the biomolecules present in the plant extract. The broad band at 3288 cm −1 is attributed to hydrogen-bonded O-H groups of alcohols or phenols or carboxylic group [13,21]. The band at 1658 cm −1 is due to the (C = O) stretching band of the carbonyl bond vibration which might indicate the presence of a carboxylic group [22].…”

“…Among the different metal oxides, CuO nanoparticles are of special interest due to their abundant availability, low cost, and biological activity [12]. It has also been reported to be non-toxic in nature, chemically stable, cost-effective, biocompatible, and biodegradable [13]. CuO NPs have been reported for the treatment of cardiovascular diseases [8,14], oxidative stress [15], and cancer [16].…”

“…CuO is one of the most useful and essential substances for the human body, providing balance and stability in tissues. It has been introduced by the US Environmental Protection Agency (EPA) as an effective antibacterial agent [13]. Accordingly, CuO can be used as a drug carrier (chemotherapeutics) for antioxidant and antimicrobial applications.…”

Nanoparticle and Nanostructure Synthesis and Controlled Growth Methods

“…(1) Zero-dimensional (0D) NMs (all three dimensions in the nanoscale; i.e., up to 100 nm) include quantum dots (carbon, graphene, inorganic) and other spherical NMs (noble metals, fullerenes, polymers, metal organic framework, Up-and down-conversion nanoparticles) [22,23]. Due to their chemical inertness, biocompatibility, optical stability, cell permeability, and wavelength-dependent photoluminescence, they are interesting for biomedical and optoelectronic applications [24].…”