In vitro antioxidant activities of Rosmarinus officinalis extracts treated with supercritical carbon dioxide

Yeşil-Çeliktaş, Özlem; Bedir, Erdal; Sukan, Fazilet Vardar

doi:10.1016/j.foodchem.2006.03.055

Cited by 88 publications

(54 citation statements)

References 18 publications

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“…De forma similar, el contenido total de fenoles de los extractos en metanol, acetato de etilo o acetona de 12 plantas aromáticas tuvo un coeficiente de correlación de 0,84 con los resultados de la capacidad antioxidante obtenidos mediante el método ABTS (Miliauskas, et al, 2004). Sin embargo, en extractos de romero obtenidos con CO 2 se obtuvo una correlación baja (r = -0,17) entre el contenido total de fenoles y la capacidad antioxidante medida por el método de ABTS (TEAC, Trolox equivalent antioxidant capacity) (Celiktas, et al, 2007). La concentración del ácido carnósico, uno de los principales componentes antioxidantes del extracto de salvia, muestra una correlación no muy alta con métodos como el DPPH (r = 0,77) y el del ácido β-linoleico (r = 0,44) (Wellwood y Cole, 2004).…”

Section: Análisis De Las Variables Del Proceso De Extracciónunclassified

Optimización de la extracción de antioxidantes de Salvia officinalis L. con CO2 supercrítico

Martı́nez¹,

Ruiz²,

Arias³

et al. 2014

Rev. Acad. Colomb. Cienc. Ex. Fis. Nat.

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ResumenSe aplicó un diseño factorial fraccionado 2 7-2 para seleccionar las variables con mayor efecto sobre la capacidad antioxidante, el contenido de fenoles y el rendimiento de la extracción utilizando CO 2 supercrítico como solvente sobre hojas y tallos de Salvia officinalis L. El tiempo de extracción, el flujo de CO 2 , la presión de la cámara de extracción y la temperatura de separación se modificaron según el procedimiento simplex para hallar empíricamente las condiciones que produjeran extractos de salvia con el valor más alto de la combinación lineal de rendimiento de extracción, capacidad antioxidante y contenido total de fenoles.Palabras clave: Salvia officinalis, supercrítico, optimización simplex, ácido carnósico. Optimization of the extraction of Salvia officinalis L. antioxidants with supercritical CO 2 AbstractA 2 7-2 fractional factorial design was used to select the variables with the greatest effect on the antioxidant capacity, the total phenolic content and the extraction yield using supercritical carbon dioxide as a solvent on Salvia officinalis L. leaves and stems. The extraction time, the CO 2 flow, the extraction chamber pressure and the collector temperature were modified according to the simplex method in order to empirically find the conditions resulting in salvia extracts with the highest value of the linear combination of extraction yield, antioxidant capacity and total phenolic content.Key words: Salvia officinalis, supercritical, simplex optimization, carnosic acid. Ciencias naturales IntroducciónLa capacidad antioxidante es una propiedad biológica de gran interés para las diversas aplicaciones de las plantas aromáticas. En la salvia (Salvia officinalis) se ha reconocido desde hace mucho tiempo esta propiedad que, junto a su poder microbicida, ha permitido usarla con éxito como preservante de cárnicos y otros alimentos (Meyer, et al., 2002). De la salvia y de otras muchas plantas aromáticas y medicinales se utilizan sus aceites esenciales, sus extractos o sus partes (hojas, flores, raíces) como ingredientes de diversas preparaciones y productos comerciales para el consumo humano. En la búsqueda de una explicación molecular de la actividad biológica de la salvia se ha demostrado que en sus metabolitos secundarios se encuentran varias sustancias que poseen alta capacidad antioxidante, tales como los ácidos fenólicos rosmarínico, salvianólico y ursólico, los flavonoides luteolina y salvicoumarina y los diterpenos fenólicos ácido carnósico, carnosol y rosmanol (Wang, et al., 1998;Lu, et al., 1999a;Lu, et al., 1999b;Lu, et al., 2000;Lu, et al., 2001). Entre estos, los ácidos rosmarínico y carnósico presentan la mayor capacidad antioxidante, superior a la del 2,6-di-terc-butil-p-cresol (BHT) y la del terc-butil-4-metoxifenol (BHA), antioxidantes de amplio uso en la industria (Sebranek, et al., 2005).En la elaboración de productos farmacéuticos y alimenticios, o en otras aplicaciones para consumo humano, es importante la eliminación de los residuos de solventes orgánicos utilizados en el...

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Section: Análisis De Las Variables Del Proceso De Extracciónunclassified

Optimización de la extracción de antioxidantes de Salvia officinalis L. con CO2 supercrítico

Martı́nez¹,

Ruiz²,

Arias³

et al. 2014

Rev. Acad. Colomb. Cienc. Ex. Fis. Nat.

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“…The works reported by Bensebia et al [6], Carvalho et al [4], Reverchon and Sanatore [5], Celiktas et al [8], Ibáñez et al [3,9] and Cavero et al [10] are some examples of 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 5 the abundant studies reported in the literature about rosemary SCCO 2 extraction. All these works were carried out over analytical (less than 1-4 grams of sample) or lowscale apparatus (30-100 grams of sample).…”

Section: Introductionmentioning

confidence: 95%

“…Celiktas et al [8] demonstrated that even applying the same process conditions, extracts obtained from leaves collected in different locations and harvesting time have rather different composition: for the different sources of rosemary leaves extracted in their work (at 35 MPa, 100°C and with 5% of methanol as co-solvent), the carnosic acid content in the extracts obtained varied from 0.5 to 11.6 % wt.…”

Section: Introductionmentioning

confidence: 99%

Kinetic study of pilot-scale supercritical CO2 extraction of rosemary (Rosmarinus officinalis) leaves

García-Risco

Hernández

Vicente

et al. 2011

The Journal of Supercritical Fluids

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Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in:Journal of Supercritical Fluids 55 (2011) AbstractRosmarinus officinalis (rosemary) extracts were obtained in a supercritical pilot-scale plant. Based on experimental information available in the literature for analytical or low-scale processes, extraction temperature and pressure were selected to be 313 K and 30 MPa. At these extraction conditions, the kinetic behavior of the pilot-scale overall extraction curve were determined with respect to yield, antioxidant activity and carnosic acid content. The overall extraction curve was represented using Sovova's model; the average deviation between measured and calculated yields was lower than 2%. Mass transfer coefficients in the fluid and solid phases were determined and were compared with previous data reported in the literature for low-scale rosemary supercritical extraction.A two-stage depressurization procedure was accomplished and the effect of both on-line fractionation and extraction time on the antioxidant activity of the samples collected was studied. The antioxidant activity of the different fractions could be straight correlated with the carnosic acid content with a regression coefficient of 0.92.

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“…Because of its strong antioxidant properties, rosemary extracts have preservative powers comparable to the commercial preservatives butylated hydroxytoluene (BHT) and butylated hydroxyanisol (BHA) [57,58]. The principal antioxidant active compounds of rosemary are phenols and terpenes like carnosic acid, carnosol, rosmanol, and rosmarinic acid, although the relative amount may vary with location and harvest season [59,60]. Various studies of extracts of rosemary leaves have demonstrated that the biologically active constituents act as free radical scavengers, and are involved in the regulation of the activity of certain enzymes ( [61][62][63][64], see Table 1).…”

Section: Rosemarymentioning

confidence: 99%

Ancient Procedures for the High-Tech World: Health Benefits and Antimicrobial Compounds from the Mediterranean Empires

Carvalho¹,

Caramujo²

2008

TOBIOTJ

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This paper reviews the benefits of the Mediterranean diet and methods developed for food processing and preservation during the time of the ancient empires. In Antiquity, trees and herbs were harvested for culinary and medicinal purposes, and from the everyday handling of products and keen observation, a great body of wisdom was derived by philosophers and physicians. With modern day techniques, the suspected properties of compounds have been investigated and the beneficial properties tested. From these studies it is apparent that olive oil, herbs, essential oils and metals, when used with the backing of scientific knowledge can improve human health and the standards of living while respecting the environment. Nowadays, proliferation of disinfectants and antimicrobial agents in domestic, industrial and medical environments has contributed to the appearance of resistant microbial strains and of new pathogens. Since regulators have restricted the use and concentrations of many preservatives, sanitizers, and antimicrobial agents, the food industry is facing a problem to extend the shelf-life of products, and to keep the manufacturing environment clean. The application of natural compounds and simple techniques developed by ancient Mediterranean civilizations may prove as useful as more modern synthetic substances, thus avoiding potential threats to human health and the environment.

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In vitro antioxidant activities of Rosmarinus officinalis extracts treated with supercritical carbon dioxide

Cited by 88 publications

References 18 publications

Optimización de la extracción de antioxidantes de Salvia officinalis L. con CO2 supercrítico

Optimización de la extracción de antioxidantes de Salvia officinalis L. con CO2 supercrítico

Kinetic study of pilot-scale supercritical CO2 extraction of rosemary (Rosmarinus officinalis) leaves

Ancient Procedures for the High-Tech World: Health Benefits and Antimicrobial Compounds from the Mediterranean Empires

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