In vitro antioxidant activity and solar protection factor of blackberry and raspberry extracts in topical formulation

Cefali, Letícia Caramori; Franco, Julia Gomes; Nicolini, Giulia Ferreira; Ataide, Janaína Artem; Mazzola, Priscila Gava

doi:10.1111/jocd.12842

Cited by 37 publications

(17 citation statements)

References 37 publications

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“…Taken together, previously published results and the current findings support blackberry's multifunctional benefits which include elastin synthesis, inhibition of elastases through anti-inflammatory pathways, potent radical scavenging activity, wound healing and solar protection properties [17,[31][32][33][34].…”

Section: Discussionsupporting

confidence: 88%

A blackberry–dill extract combination synergistically increases skin elasticity

Meza

Seo

et al. 2020

Intern J of Cosmetic Sci

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Background The loss of structural elastin due to intrinsic and extrinsic ageing results in the skin’s inability to stretch and recoil (decrease in elasticity) and manifests as loss of skin firmness and sagging. While other extracellular matrix (ECM) components such as collagen and hyaluronic acid are continually synthesized and assembled through life, elastic fibres are not. Elastic fibre assembly and functionality require fibre cross‐linking, induced by the lysyl oxidase‐like (LOXL) enzymes, which sharply decrease during ageing. Objective To evaluate the enhanced elastogenic effect of a blackberry–dill extract combination, which was hypothesized to induce elastin fibre component synthesis, fibre cross‐linking and reduce elastin fibre degradation. Methods The blackberry and the dill extracts were tested separately and in combination to confirm single ingredient bioactivity and synergistic benefits. Human skin explants, dermal fibroblasts, elastase assays, ELISAs, quantitative real‐time PCRs and spectrofluorometer measurements were used. Moreover, a double‐blinded, placebo‐controlled clinical study was carried out to assess skin elasticity using Cutometer and histologically from biopsies. Results The blackberry extract induced elastin gene expression, elastin promoter activity and inhibited elastic fibre degradation by matrix metalloproteinases (MMPs) 9 and 12. The dill extract induced elastin, collagen and LOXL1 gene expression, resulting in enhanced fibre cross‐linking in human skin explants. Clinically, the blackberry and dill combination treatment displayed synergistic pro‐elasticity activity as compared to each ingredient alone and placebo. Conclusion Taken together, these results demonstrated the two multimodal plant‐based extracts complemented each other in terms of bioactivity and resulted in a synergistic elastogenesis induction.

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Section: Discussionsupporting

confidence: 88%

A blackberry–dill extract combination synergistically increases skin elasticity

Meza

Seo

et al. 2020

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

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“…In another study, blackberry and raspberry extracts of anthocyanins were tested for the same purpose and the in vitro solar protection factor (SPF) was found to be 54.57 for blackberry and 37.32 for raspberry, promising values for new sun filters development. Overall, the formulations containing the extracts exhibited pH and density stability, pink color, and creamy aspect, although indirect light and stove conditions resulted in a slight color change, suggesting they should be kept under refrigeration and in opaque package to ensure stability [ 91 ]. Additionally, the photoprotective effects of strawberry-based formulations enriched with Coenzyme Q10 (CoQ10) were tested in UV exposed human dermal fibroblasts.…”

Section: Photo-oxidative Damage and The Role Of Anthocyaninsmentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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“…In this contest, antioxidants from natural source, including botanicals, are increasingly used to improve skin inflammatory and oxidative stress conditions [21]. In the last few years, a variety of botanicals have been tested for their antioxidant and anti-inflammatory activities, mostly due to the high content of polyphenols [22,23,24,25]. However, the support for the topical use in psoriasis is limited by the number of studies available in the literature [26].…”

Section: Introductionmentioning

confidence: 99%

Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases

et al. 2019

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Psoriasis is a chronic cutaneous condition characterized by the release of pro-inflammatory mediators and oxidative stress. The reduction of these factors is currently the most effective strategy to inhibit the symptoms of pathology. Antioxidants from natural sources are increasingly used to improve skin conditions. Dried red leaves from grapevine (Vitis vinifera L., cv Teinturiers) showed anti-inflammatory and anti-bacterial activities, but their possible effects on keratinocytes have not been previously investigated. In this study we tested the ability of a water extract from grapevine leaves (VVWE) to inhibit inflammatory conditions in human keratinocytes (HaCaT cells), challenged with proinflammatory (tumor necrosis factor-α (TNF-α) or lipopolysaccharide (LPS)) or prooxidant (ultraviolet B radiation (UVB) or H2O2) mediators. VVWE inhibited interleukin-8 (IL-8) secretion induced by proinflammatory stimuli, acting on the IL-8 promoter activity, but the effect was lower when prooxidant mediators were used. The effect was partly explained by the reduction of nuclear factor-κB (NF-κB)-driven transcription and nuclear translocation. Furthermore, vascular endothelial growth factor (VEGF) secretion, a regulator of angiogenesis, was inhibited by VVWE, but not matrix metalloproteinase-9 (MMP-9), a protease involved in matrix remodeling. VVWE, assayed on Franz diffusion cell system, showed a marked reduction of High Performance Liquid Chromatography (HPLC)-identified compounds. Pure molecules individually failed to reduce TNF-α-induced IL-8 release, suggesting synergistic effects or the presence of other bioactive compounds still unknown.

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In vitro antioxidant activity and solar protection factor of blackberry and raspberry extracts in topical formulation

Cited by 37 publications

References 37 publications

A blackberry–dill extract combination synergistically increases skin elasticity

A blackberry–dill extract combination synergistically increases skin elasticity

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases

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