In vitro Antioxidant and Antiproliferative Activities of Flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) Leaves

Said, Ataa; Tundis, Rosa; Hawas, Usama W.; El-Kousy, Salah M.; Rashed, Khaled; Menichini, Francesco; Bonesi, Marco; Huefner, Antje; Loizzo, Monica Rosa

doi:10.1515/znc-2010-3-403

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…As A549 line has been widely used as a model system to study human alveolar carcinoma, cytotoxic profile of flavonoids in these cells was previously characterized with the results very similar to those measured in our work. Indeed, the IC 50 value of 72.2 µM for quercetin is close to the inhibitory constants published by Loizzo et al (26), Tan et al (27)(28)(29), Robaszkiewicz et al (30), and Chan et al (31); and IC 50 values more than 100 µM were previously reported for fisetin (32), hesperetin (33-35), luteolin (32,36), chrysin (35), baicalein (34), daidzein (37), and genistein (38). Based on our results presented in this article, cytotoxic activity profiles of flavonoids were rather similar for both A549 and HCC-44 lung cancer lines, despite the gender difference of initial origin of these cells.…”

Section: Discussionsupporting

confidence: 86%

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

et al. 2017

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Abstract. Lung cancer is the malignant disorder associated with a high number of fatalities in women and men worldwide. Despite continuous improvements in diagnostic strategies and therapeutic modalities over the past decades, the prognosis and survival rate of patients suffering from lung cancer are still unsatisfactory and suggest the requirement for further molecular studies with different lung cancer models. In the present study, the anticancer action of two methylated metabolites of quercetin, isorhamnetin and tamarixetin, was assessed by studying their antiproliferative and apoptosis-inducing potential in human lung adenocarcinoma cell lines, A549 and HCC-44. Both methylquercetins decreased the viability of lung cancer cells at doses significantly lower than those effective for parent quercetin. The IC 50 values measured for isorhamnetin were 26.6 and 15.9 µM in A549 and HCC-44 cells, respectively. For tamarixetin, the IC 50 values were 19.6 and 20.3 µM in A549 and HCC-44 cells, respectively. These results were many-fold lower than the respective values for quercetin (72.2 and 107.6 µM for A549 and HCC-44 cells, respectively). Based on the activation of caspase family members, both metabolites induced apoptotic cell death in the tested cell lines, predominantly via the extrinsic pathway in A549 cells and in both intrinsic and extrinsic pathways in HCC-44 cells. As A549 and HCC-44 lines were originally established from a male and female patient, current data may suggst some gender differences in the action of quercetin derivatives. Addition of a methyl group in the 3'-or 4'-position of the B-ring of quercetin significantly increased the anticancer activity of this flavonol towards lung adenocarcinoma cells, which demonstrated that these compounds may be considered as potential novel candidates for the development of future chemotherapeutics in the fight against lung cancer.

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Section: Discussionsupporting

confidence: 86%

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

et al. 2017

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“…It is traditionally used for the treatment of jaundice, heart diseases, tumors, gastric problems, inflammation, and asthma (Mani & Rathore, 2016). It appears to have a diverse range of biological activities, including antiinflammatory, antiasthmatic, hepatoprotective, and antioxidant (Said et al, 2010). Antiimplantation and early abortifacient activities were observed in female rats which received alcoholic extracts of the plant (Dhanasekaran, Suresh, Sethuraman, Rajan, & Dubey, 1993).…”

Section: Methodsmentioning

confidence: 99%

Is it safe to consume traditional medicinal plants during pregnancy?

Bernstein

Akram

Yaniv-Bachrach

et al. 2020

Phytotherapy Research

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The popularity of natural medicine is growing worldwide. Unlike conventional licensed medicines, herbal medicine practices are usually not supported by effectiveness, efficacy, or safety studies, which raise concerns about potential risks involved in their usage, particularly in high‐risk patients such as pregnant women where teratogenicity is a concern. Despite a lack of science‐based evidence, the use of herbal products for the management of pregnancy‐associated challenges is common, due to the common notion that they are free of toxic effects and adverse reactions because they are “natural.” The lack of concern about utilizing herbal remedies during pregnancy is strengthened by the lack of regulation in most countries for their marketing. However, plant‐based remedies are not free of adverse reactions. Medicinal plants and herbal remedies contain substances that can be toxic to the human body and the fetus. Potential effects of indiscriminate use of medicinal plants are embryotoxicity, teratogenic, and abortifacient effects. Some plant constituents can cross the placenta and reach the fetus. Phytochemicals and their metabolites are known to induce stimulation of uterine contraction and hormone imbalance that could result in abortion. The alterations to the hormonal profile can affect conception, induce teratogenic activity, and halt the pregnancy or produce a congenital malformation. Due to the wide range of modes of action of phytochemicals, some medicinal plants may be safe to use during certain trimesters of pregnancy and harmful at other stages. This manuscript reviews available scientific information concerning potential health hazards associated with the consumption of herbal medicines during pregnancy, highlighting those herbs that should be avoided due to their potential abortifacient and/or teratogenic activity. We focused on plants that were tested by preclinical studies, and studies of these plants are summarized. Common therapeutic use of these herbs, estimated effects, toxicological effects, and animal studies of these plants is summarized. The literature reviewed suggests that consumption of the following medicinal plants should be avoided during pregnancy: Abrus precatorius, Achyranthes aspera, Ailanthus excelsa, Aloe vera, Aristolochia indica, Areca catechu, Bambusa vulgaris, Cassia occidentalis, Cicer arietinum, Cimicifuga racemose, Dolichandrone falcate, Ginkgo biloba, Hydrastis canadensis, Indigofera trifoliate, Lavandula latifolia, Maytenus ilicifolia, Momordica cymbalaria, Moringa oleifera, Musa rosacea, Oxalis corniculate, Phytolacca dodecandra, Plumeria rubra, Ricinus communis, Ruta graveolens, Stachys lavandulifolia, Senna alata, Trigonella foenum‐graecum, Vitus agnus‐castus, and Valeriana officinalis.

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“…Studies have shown that EGCG, catechins, luteolin, baicalein and kaempferol are flavonoids with antioxidation activity. These compounds display antimelanoma effect via inhibiting cell proliferation, invasion and inducing apoptosis with multiple pharmacological mechanisms [25][26][27][28][29][30][31][32]. Flavonoids exhibit anti-proliferative and apoptotic effects via HGF/SF-Met signaling, PI3K-AKT pathway, MAPK pathway or cell cycle regulation in melanogenesis.…”

Section: Discussionmentioning

confidence: 99%

The antioxidation and antiproliferation activity of flavonoids from Aquilaria agallocha and Aquilaria sinensis

Liu¹,

Perng²,

Chen³

2018

biomedicalresearch

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Studies have shown that herbal extractions may be effective against various diseases like cancer and cardiovascular disease. In this study, we intended to evaluate the cytotoxicity and antioxidation activity of phytochemical constituents from the leaves of Aquilaria agallocha and the stems of Aquilaria sinensis.The chemical structures were identified by UV, IR, ESI-MS, 1H NMR and 13C NMR analyses. 5-hydroxy-7, 4'-dimethoxyflavone (1), 5, 3'-dihydroxy-7, 4'-dimethoxyflavone (2), 5-hydroxy-7, 3', 4'-trimethoxyflavone (3), 5, 7, 4′-trihydroxyflavone (4), and 3', 4', 5, 7-tetrahydroxyflavone (5) were isolated and further examined antioxidation and antiproliferation activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and MTT assay. According these results, 5-hydroxy-7, 3', 4'-trimethoxyflavone (3) had DPPH radical scavenging activity. Further, 5-hydroxy-7, 3', 4'-trimethoxyflavone (3) also showed significant positive anticancer activities (10-100 μM) against human skin cancer cell line A375 cells.

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In vitro Antioxidant and Antiproliferative Activities of Flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) Leaves

Cited by 19 publications

References 30 publications

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

Is it safe to consume traditional medicinal plants during pregnancy?

The antioxidation and antiproliferation activity of flavonoids from Aquilaria agallocha and Aquilaria sinensis

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