In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br.

Mary, N K; Achuthan, C R; Babu, B. Hari; Padikkala, José

doi:10.1016/s0378-8741(03)00119-3

Cited by 69 publications

(50 citation statements)

References 13 publications

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“…In our study, H. indicus co-administered rats showed significantly decreased levels of these lipid peroxidative markers as compared to the ethanol-fed rats. In this context, Mary et al [51] reported the antioxidant property of H. indicus based on in vitro studies. Decreased lipid peroxidation upon H. indicus extract administration suggests the decreased impact of ROS on the membranes, and thereby increased protection against ethanol-induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

Hemidesmus indicus Protects against ethanol-induced liver toxicity

Saravanan

Nalini

2008

Cellular and Molecular Biology Letters

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Alcoholic liver disease (ALD) is one of the most common diseases in modern society. A large number of studies are in progress aiming to identify natural substances that would be effective in reducing the severity of ALD. Although there are currently a number of drugs on the market, their long-term use can have numerous side effects. Hemidesmus indicus is an indigenous Ayurvedic medicinal plant used in soft drinks in India. In this study, we examined the effects of its ethanolic root extract on experimental liver damage in order to evaluate its hepatoprotective effects against hepatotoxicity induced in rats by ethanol at a dosage of 5 g/kg body weight for 60 days. The H. indicus root extract was given at a dose of 500 mg/kg body weight for the last 30 days of the experiment. The animals were monitored for food intake and weight gain. The liver was analysed for the degree of lipid peroxidation using thiobarbituric acid reactive substances (TBARS) and antioxidant status using the activities of glutathione-depedendant enzymes. The degree of liver damage was analysed using serum marker enzyme activities, the total protein, albumin, globulin, ceruloplasmin and liver glycogen contents, and the A/G ratio. The Fourier transform infrared spectra (FT-IR) of the liver tissues were recorded in the region of 4000-400 cm -1 . The ethanol-fed rats showed significantly elevated liver marker enzyme activities, lipid peroxidation levels and reduced antioxidant levels as compared to the control rats. Oral administration of H. indicus for the latter 30 days resulted in an increased food intake and weight gain, decreased TBARS levels, near normal levels of glutathione-dependent enzymes, increased total protein, albumin, globulin and liver glycogen contents, an increased A/G ratio, and decreased liver marker enzyme activities and ceruloplasmin levels. The relative intensity of the liver FT-IR bands for the experimental groups were found to be altered significantly (p < 0.05) compared to the control samples. For the group that had H. indicus co-administered with ethanol, the intensity of the bands was near normal. Moreover, the results of the FT-IR study correlated with our biochemical results.

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Section: Discussionmentioning

confidence: 99%

Hemidesmus indicus Protects against ethanol-induced liver toxicity

Saravanan

Nalini

2008

Cellular and Molecular Biology Letters

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“…HI possesses an antioxidant effect (Mary et al, 2003;Rao et al, 2005), which might be due to tannins (Hong et al, 1995), some of its main constituents. Further, saponins are shown to have beneficial effects on cardiovascular diseases (Matsuura, 2001).…”

Section: Resultsmentioning

confidence: 99%

Effect ofHemidesmus indicuson ischemia–reperfusion injury in the isolated rat heart

Khandelwal

Balaraman

Ondrejcakova

et al. 2010

Pharmaceutical Biology

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“…Since ancient time, medicinal plants are a major source of secondary metabolites, which play a key role in the highly effective free radical scavengers and antioxidant and biological activities [49]. The antioxidant activity of alcoholic extract of HI has been demonstrated earlier in numerous methods [50][51][52]. However, the potential of free radical scavenging ability of HI roots in chemical and biological systems has not been comprehensively investigated.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Free Radical Scavenging Activity and in Vivo Anticataract Potential of Hemidesmus Indicus Roots in Streptozotocin Induced Diabetic Rats

Tirumani

2017

Asian J Pharm Clin Res

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Objective: Hemidesmus indicus R. Br. (HI) (Indian sarsaparilla) is traditionally used in Indian medicine for human therapy. The present study was aimed to evaluate the antioxidant activity of HI root extracts, and its effects on delaying (or) management of cataract progression in streptozoticin (STZ) induced diabetic rats. Methods:The plant roots were extracted in different solvents, estimated total phenolic content, total flavonoid content and conducted free radical scavenging potential through 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2 azinobis (3-ethyl benzothiazoline-6-sulphonic acid diammonium salt (ABTS) NO, OH and reducing power assays. Further, the protective effect was evaluated in STZ induced diabetic rats through administered of ethyl acetate extract of HI (200 and 400 mg/kg body weight) orally for 8 weeks to study its effect on oxidative stress and diabetic cataract progression. Results:In primary results demonstrated that the ethyl acetate extract has been showed considerable free radical scavenging activity and significantly gain body weight, gradual decreasing blood glucose levels and delay cataract progression has been observed in HI treated rats. Furthermore, we observed significantly decreased oxidative stress markers, and restoration of the antioxidant system in HI treated rats. Lens sections from experimental animal again evidenced to conform the ameliorative effect of HI on diabetic cataract. Conclusion:This obtained result's confirmed that the protective effect of HI is attributed to the antioxidant activities of plant roots and its active principles.

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In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br.

Cited by 69 publications

References 13 publications

Hemidesmus indicus Protects against ethanol-induced liver toxicity

Hemidesmus indicus Protects against ethanol-induced liver toxicity

Effect ofHemidesmus indicuson ischemia–reperfusion injury in the isolated rat heart

In Vitro Free Radical Scavenging Activity and in Vivo Anticataract Potential of Hemidesmus Indicus Roots in Streptozotocin Induced Diabetic Rats

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