In vitro antioxidant and in vivo antidepressant activity of green synthesized azomethine derivatives of cinnamaldehyde

Chigurupati, Sridevi; Shaikh, Sohrab Akhtar; Mohammad, Jahidul Islam; Selvarajan, Kesavanarayanan Krishnan; Nemala, Appala Raju; Khaw, Chu How; Teoh, Chun Foo; Kee, Ting Hei

doi:10.4103/ijp.ijp_293_16

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…ABTS+ solution was added and incubated for 30 min. The absorbance was measured at 734 nm 21 . The percentage of scavenging can be calculated using the equation (Eq.1).…”

Section: Determination Of Total Flavonoid Content (Tfc)mentioning

confidence: 99%

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2020

IJPSR

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The study aims to investigate the antioxidant and antidiabetic activity of Leucaena leucocephala ethanol leaf extract (LLME). L. leucocephala leaves extraction was carried out by the maceration method. Phytochemical analysis was performed using standard analytical procedures. Diphenyl picrylhydrazyl (DPPH) radical and 2, 2'-azinobis (3-ethylbenzathiazoline-6-sulfonic acid) (ABTS) radical scavenging assay; α-amylase and α-glucosidase inhibition assays were performed. The extraction yield of LLME by maceration was 65%. The phytochemical screening confirmed the presence of alkaloids, monosaccharides, proteins, amino acids, steroids, flavonoids, glycosides, tannins, and saponins. The total phenol content of LLME was 970 mg of GAE/g, and total flavonoid content was found to be 550 mg of QE/g. In DPPH and ABTS assay LLME showed good antioxidant activity (IC 50 : 11.21 ± 0.2 and 11.87 ± 0.05 µg/mL) when compared to the standard drug, ascorbic acid (IC 50 :11.09 ± 0.05 and 11.01 ± 0.09 µg/mL). Similarly, in α-amylase and α-glucosidase inhibition assay, acarbose revealed enzyme inhibition activity with an IC 50 value of 12.02 ± 0.02 and 12.11 ± 0.02 µg/mL while LLME showed an IC 50 value of 12.46 ± 0.06 and 12.47 ± 0.08 µg/mL, respectively. The present study leads to the conclusion that L. leucocephala ethanol leaf extract is with tremendous antioxidant and antidiabetic properties.

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“…ABTS+ solution was added and incubated for 30 min. The absorbance was measured at 734 nm 21 . The percentage of scavenging can be calculated using the equation (Eq.1).…”

Section: Determination Of Total Flavonoid Content (Tfc)mentioning

confidence: 99%

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2020

IJPSR

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“…Silver nanoparticles prepared from Salvia officinalis extract have been reported to possess antioxidant and anti-inflammatory activities [12]. Similarly, azomethine synthesized from cinnamaldehyde, obtained from the bark of a cinnamon tree, has been shown to have antidepressant activity [13]. In this study, we have synthesized hydroxamic acid from the seeds of Cyperus esculentus (common name Tiger nut).…”

Section: Introductionmentioning

confidence: 99%

Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

2020

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Background: Hydroxamic acids are currently being used in diverse biological activities. We investigated the effect of hydroxamic acid, synthesized from Cyperus esculentus seeds, on the antioxidant status of the liver, spleen, and kidney of Wistar rats. Methods: Twenty male rats were randomly divided into three treatment groups using hydroxamic acid at doses of 5, 15, and 50 mg/kg and a control group using distilled water. Rats were sacrificed 24 h after a seven-day repeated oral dosing. After that, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and the levels of glutathione (GSH) and malondialdehyde (MDA) were investigated in the organs. Results: Our data showed that MDA levels remained unaltered in the liver, spleen, and kidney. However, it was found that hydroxamic acid at the dose of 50 mg/kg significantly increased SOD activity but depleted CAT, GPx activities and GSH levels in the liver when compared to the control groups. In splenic tissue, SOD activity and GSH levels were significantly diminished. Contrarily, in the kidney, treatment of rats with 50 mg/kg hydroxamic acid did not affect SOD activity, but GPx activity was increased while GST activity was decreased when compared to the controls. Conclusion: Overall, hydroxamic acid may enhance antioxidant enzyme activities in the liver and kidney. However, caution is required at higher doses to forestall oxidative stress in the hepatic and splenic tissues.

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“…ve IV. gruptaki hayvanlara ise %25'lik DMSO'da çözünen 3-MTA bileşiğinden hazırlanan solüsyondan 7 gün süreyle sırasıyla 10 mg/kg ve 50 mg/kg intraperitonal olarak uygulanmıştır [13].…”

Section: Introductionunclassified

Heterosiklik 4,5-dihidro-1H-1,2,4-triazol-5-on Türevinin Antioksidan Özelliğinin Erkek Ratlarda (Wistar albino) İn vivo Olarak Belirlenmesi

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et al. 2020

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

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Öz 4,5-Dihidro-1H-1,2,4-triazol-5-on türevli heterosiklik bileşikler sanayide, tıpta, eczacılıkta ve kimyanın pek çok alanında önemli yere sahiptir. Bu bileşiklerin bazı biyolojik aktivite özellikleri in vitro olarak incelenmiş olup bazılarının yüksek aktivite gösterdikleri belirlenmiştir. Bu aktivitelerden biri de 1,2,4-triazol-5-on türevlerinin göstermiş olduğu antioksidan özelliğidir. Mevcut araştırmada da, 3-metil-4-(3,4-dihidroksibenzilidenamino)-4,5dihidro-1H-1,2,4-triazol-5-on (3-MTA) bileşiğinin antioksidan özellik gösterip göstermediği ratlarda in vivo olarak spektrofotometrik yöntemle belirlenmiştir. Bu amaçla hayvanlar; kontrol grubu, dimetil sülfoksit (DMSO) grubu, 10 mg/kg ve 50 mg/kg 3-MTA bileşiği içeren gruplar olacak şekilde 4'e ayrılmıştır. Yapılan spektrofotometrik analizler neticesinde kontrol grubuna kıyasla serumda 10 ve 50 mg/kg dozunda 3-MTA bileşiği uygulanan gruplarda (P<0.01), böbrek dokusunda ise 50 mg/kg dozunda 3-MTA bileşiği uygulanan grupta total antioksidan düzeyleri (TAD) artış göstermiştir (P<0.001). Bununla birlikte; böbrek dokusu total oksidan düzeyinin (TOD) ise kontrol grubuna göre 50 mg/kg 3-MTA bileşiği uygulanan grupta azaldığı belirlenmiştir (P<0.05). Sonuç olarak; elde edilen verilere göre, 3-MTA bileşiğinin sıçanlarda uygulanan doz ve sürede toksik etki göstermediği, serum ve böbrek TAD düzeyindeki artış ve böbrek TOD düzeyindeki azalmaya göre de olumlu biyolojik aktiviteye sahip olduğu kanısına varılmıştır.

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In vitro antioxidant and in vivo antidepressant activity of green synthesized azomethine derivatives of cinnamaldehyde

Cited by 5 publications

References 26 publications

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Green synthesized hydroxamic acid administered in high dose disrupts the antioxidant balance in the hepatic and splenic tissues of albino rats

Heterosiklik 4,5-dihidro-1H-1,2,4-triazol-5-on Türevinin Antioksidan Özelliğinin Erkek Ratlarda (Wistar albino) İn vivo Olarak Belirlenmesi

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