In-vitro antioxidant, antidiabetic, anticholinergic activity of iron/copper nanoparticles synthesized using Strobilanthes cordifolia leaf extract

Kirubakaran, Dharmalingam; Selvam, Kuppusamy; Prakash, Palanisamy; Shivakumar, Muthugounder Subaramanian; Rajkumar, Manickam

doi:10.1016/j.onano.2023.100188

Cited by 14 publications

(3 citation statements)

References 46 publications

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“…A clear zone of inhibition was observed with a diameter measured in millimeters after a 24 hour incubation period at 37 °C. [28,29]…”

Section: Antibacterial Activitymentioning

confidence: 99%

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Kirubakaran,

Selvam,

Subramanian Shivakumar

et al. 2024

ChemistrySelect

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Strobilanthes cordifolia has emerged as a promising material in traditional medicine. In this study, we have made an attempt to synthesize zinc oxide nanoparticles derived from S. cordifolia leaf. The team employed a wide range of techniques including UV, FT‐IR, XRD, FE‐SEM with EDAX, HR‐TEM with SAED, DLS, Zeta potential, BET and PZC analysis to thoroughly examine the properties of the NPs. FTIR analysis provided evidence of various functional groups within the NPs. XRD analysis demonstrated the crystal nature and phase purity of the NPs. SEM analysis showcased the spherical shape of the particles, while TEM revealed their rod‐like shape with sizes averaging at approximately 10 nm. DLS analysis indicated the average particle size, and the high zeta potential value confirmed the stability and BET analysis deciphered the specific surface area of the biosynthesized NPs. The NPs confirmed strong antioxidant properties with DPPH, ABTS, and hydroxyl radicals. Enzyme studies confirmed good anti‐cholinergic activity and anti‐inflammatory efficacy, highlighting their potential therapeutic benefits. The NPs demonstrated promising wound healing properties. Overall, this research study sheds light on the medicinal aspects of zinc oxide nanoparticles from S. cordifolia leaf extract and it offers exciting prospects for future exploration and development in this field.

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“…A clear zone of inhibition was observed with a diameter measured in millimeters after a 24 hour incubation period at 37 °C. [28,29]…”

Section: Antibacterial Activitymentioning

confidence: 99%

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Kirubakaran,

Selvam,

Subramanian Shivakumar

et al. 2024

ChemistrySelect

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“…Hence, the α-amylase and α-glucosidase inhibition assays, provide strong evidence for the effectiveness of synthesized metformin HCl-loaded Na-Alg/PSA/CMTKG hydrogel for the diabetes management. [32]…”

Section: α-Glucosidase Inhibition Assaymentioning

confidence: 99%

“…So, as the enzyme adhere to the surface of hydrogel, less free α-Amylase enzyme left to interact with starch, hence less conversion of starch into sugar. [32]…”

Section: α-Amylase Inhibition Assaymentioning

confidence: 99%

Preparation and Characterization of Sodium Alginate‐Based Hydrogel for Delivery of Hydrophilic Drug Metformin Hydrochloride

Shrila,

Ananya,

Meena

et al. 2024

ChemistrySelect

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This research delves into the development of a hydrogel based on sodium alginate (Na‐Alg), CMTKG and PSA for the controlled release of Metformin Hydrochloride (Metformin HCl), a commonly used drug for the treatment of type 2 diabetes. The hydrogel was synthesized via a free radical mechanism using N, N′‐methylene‐bis(acrylamide) (MBA) as a crosslinker and potassium persulphate (KPS) as an initiator. The hydrogels were analyzed using techniques such as ATR‐FTIR, and SEM. The research also investigated swelling behaviour, drug loading, drug encapsulation efficiency, and release kinetics of Metformin HCl. The finding revealed that the hydrogel exhibited pH‐responsive metformin HCl release, with higher drug release perceived at pH 7.4 compared to pH 1.2. Mathematical models were employed to study the drug release mechanism, indicating diffusion as a mechanism liable for the drug release from the hydrogel. Moreover, the synthesized metformin HCl‐loaded Na‐Alg/PSA/CMTKG hydrogel shows excellent anti‐diabetic activity on α‐amylase and α‐glucosidase enzyme. Henceforth, the formulated hydrogel reveals potential for facilitating the targeted release of Metformin HCl, offering opportunities for improving patient amenability and lessening side effects related to frequent dosing.

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Biosynthesis and biological activities of magnesium hydroxide nanoparticles using Tinospora cordifolia leaf extract

Rajkumar,

Presley,

Menaa

et al. 2024

Bioprocess Biosyst Eng

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In-vitro antioxidant, antidiabetic, anticholinergic activity of iron/copper nanoparticles synthesized using Strobilanthes cordifolia leaf extract

Cited by 14 publications

References 46 publications

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Preparation and Characterization of Sodium Alginate‐Based Hydrogel for Delivery of Hydrophilic Drug Metformin Hydrochloride

Biosynthesis and biological activities of magnesium hydroxide nanoparticles using Tinospora cordifolia leaf extract

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