In vitro antioxidant effect of aqueous extract of Solanum macrocarpon leaves in rat liver and brain

Adewale, Olusola Bolaji; Onasanya, A.; Fadaka, Adewale Oluwaseun; Iwere, Hilda; Anadozie, Scholastica Onyebuchi; Osukoya, Olukemi Adetutu; Olayide, Israel

doi:10.5455/oams.191214.or.079

Cited by 13 publications

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“…The mechanism of action of phenolic compounds in relation to its antioxidative activity is by nullifying free radicals and preventing the breakdown of hydroperoxides into free radicals (Adewale et al, 2014 The results gotten from this study showed that ethyl acetate fraction of S. macrocarpon leaves exhibited metal ion chelating ( Figure 3) and ABTS radical scavenging abilities (Figure 4). The ethyl acetate fraction of S. macrocarpon leaves was able to chelate Fe 2+ in a concentration-dependent manner.…”

Section: Discussionmentioning

confidence: 75%

“…S. macrocarpon is known to have medicinal benefits and these benefits have been ascribed to the phytochemicals in it such as phenols and flavonoids (Adewale et al, ; Oboh, Olasehinde, & Ademosun, ). Phenolics or polyphenols present in plant and plant products are secondary metabolites (Adewale et al, ). Phenolic compounds have been reported to wield pharmacological effects and this is related to their antioxidant capability (Adewale et al, ; Ajiboye et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Phenolics or polyphenols present in plant and plant products are secondary metabolites (Adewale et al, ). Phenolic compounds have been reported to wield pharmacological effects and this is related to their antioxidant capability (Adewale et al, ; Ajiboye et al, ). Ethyl acetate fraction of S. macrocarpon leaves showed a high phenolic and flavonoid contents (Figure ).…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism of action of phenolic compounds in relation to its antioxidative activity is by nullifying free radicals and preventing the breakdown of hydroperoxides into free radicals (Adewale et al, ). Studies have shown that free radicals are associated with neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease), hypertension, erectile disfunction, endothelial disfunction, and hyperpigmentation (Steppan, Nyhan, & Derkowitz, ).…”

Section: Discussionmentioning

confidence: 99%

“…S. macrocarpon is known to have medicinal benefits and these benefits have been ascribed to the phytochemicals in it such as phenols and flavonoids (Adewale et al, 2014;Oboh, Olasehinde, & Ademosun, 2014). Phenolics or polyphenols present in plant and plant products are secondary metabolites (Adewale et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory effect of ethyl acetate fraction ofSolanum macrocarponL. leaves on cholinergic, monoaminergic, and purinergic enzyme activities

et al. 2018

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This study evaluated the inhibitory effect of ethyl acetate fraction of Solanum macrocarpon L. leaves on cholinergic, monoaminergic, purinergic enzyme activities and identification of bioactive compounds. 2,2‐azino‐bis‐3‐ethylbenthiazoline‐6‐sulphonic acid (ABTS), metal ion chelating radicals scavenging activity, total phenolic and flavonoid contents were determined using standard methods. The inhibitory effects of the ethyl acetate fraction of S. macrocarpon on the specified enzymes were determined spectroscopically. Ethyl acetate fraction of S. macrocarpon showed a high ABTS radical scavenging activity and metal ion chelating radical scavenging activity. The fraction showed high contents of phenol and flavonoid. The fraction also inhibited AChE, BChE, MOA, tyrosinase, arginase, ecto‐5′ ‐nucleotidase, PDE‐5, ACE and stimulated the activity of Na+/K+‐ATPase. Bioactive compounds present in ethyl acetate fraction of S. macrocarpon leaves include kaempferol‐3‐rutinoside, rutin among others. Ethyl acetate fraction of S. macrocarpon leaves inhibited cholinergic, monoaminergic, and purinergic enzymes and had a stimulatory effect on Na+/K+‐ATPase. Practical applications Solanum macrocarpon L. leaves are commonly consumed as vegetable. The enormous medicinal potential of the ethyl acetate fraction is invaluable as it’s a probable source of polyphenols characterized with strong antioxidant activity. In addition, the leaves are used as functional foods and may play a crucial role in the management/treatment of diabetes mellitus, neurodegenerative diseases, and erectile dysfunction.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The mechanism of action of phenolic compounds in relation to its antioxidative activity is by nullifying free radicals and preventing the breakdown of hydroperoxides into free radicals (Adewale et al, ). Studies have shown that free radicals are associated with neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease), hypertension, erectile disfunction, endothelial disfunction, and hyperpigmentation (Steppan, Nyhan, & Derkowitz, ).…”

Section: Discussionmentioning

confidence: 99%