In-vitro antioxidant, lipoxygenase inhibitory, and in-vivo muscle relaxant potential of the extract and constituent isolated from Diospyros kaki (Japanese Persimmon)

Mujawah, Adil A. H.; Bawazeer, Sami; Wadood, Abdul; Hemeg, Hassan A.; Bawazeer, Saud

doi:10.1016/j.heliyon.2023.e13816

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…These findings concur with Rehman et al (2020) and Sembiring and Purba (2020), who described the antioxidant activity of methanol extracts of D. malabarica and D. celebica leaves against DPPH free radicals. Mujawah et al (2023) also found that any part of other species, such as Diospyros kaki L.f., had antioxidant activity because of the presence of phytochemicals, including dinaphthodiospyrol S and 7'dimethyl-[2,2-binaphthalene]-5,5',8,8'-tetraone. Meanwhile, Arrisujaya et al (2020) reported that methanol extracts of D. blancoi had the highest antioxidant activity against DPPH free radicals with an SC50 value of 2.72 μg/mL.…”

Section: Antioxidant Propertiesmentioning

confidence: 87%

“…According to reports, triterpene, coumarin, naphthoquinone, and other phenolic chemicals have all been found in Diospyros species. They are also recognized for their anti-inflammatory, antipyretic, antifungal, antioxidant, and antiplasmodial properties (Khan et al 2016;Sulub-Tun et al 2020;Tameye et al 2020;du Preez-Bruwer et al 2022;Tameye et al 2022;Mujawah et al 2023). Therefore, these methods inspired the authors to search and apply Diospyros sp.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia

RAMADHAN,

ROSYIDAH,

FIRDAUS

et al. 2023

Biodiversitas

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Abstract. Ramadhan R, Rosyidah N, Firdaus YFH, Kurnia IT, Lestari DA, Phontree K, Phuwapraisirisan P, Riyadi L, Rahman A, Abdulgani N, Maretna SA, Fadhila KN. 2023. Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia. Biodiversitas 24: 4783-4790. Locals who live in forested areas have long relied on Non-Timber Forest Products (NTFPs) for their traditional ceremonies, food, and medicine. As non-timber forest products, medicinal plants are of interest since they are used by locals in East Kalimantan regions, Indonesia, for local traditional medicine. In the search for new potential antidiabetics and antioxidants created from natural resources, the authors concentrated on medicinal plants traditionally used in East Kalimantan and ethnopharmacological data. The purpose of this study is to evaluate the dual roles of non-timber forest products, such as three Diospyros L. species, in a-glucosidase inhibition, antioxidant (free radical scavenging activity against DPPH and ABTS), and CUPRAC in-vitro activities. This study showed that the strongest a-glucosidase inhibitory activity was found in ethyl acetate and ethanol residue extracts of Diospyros celebica Bakh., with IC50 values of 4.5804±0.14 ug/mL and 3.8236±0.19 ug/mL respectively, which were more potent than quercetin as a positive standard. Additionally, the antioxidant test revealed that leaf extracts of three Diospyros species from East Kalimantan are excellent sources of natural antioxidants, as demonstrated by the SC50 values. The findings of this study support and validate the use of leaf extracts of three Diospyros species in traditional East Kalimantan medicine.

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Section: Antioxidant Propertiesmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia

RAMADHAN,

ROSYIDAH,

FIRDAUS

et al. 2023

Biodiversitas

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show abstract

“…Naphthoquinones, naturally occurring substances, show numerous biological activities such as antimicrobial, 8 antibacterial, 9 antioxidant, 10 cytotoxic, 11 and antiviral properties, 12 among others. 13 These compounds are closely related to various biochemical processes and biological activities within cells, especially through their participation in the redox cycle.…”

Section: Introductionmentioning

confidence: 99%

New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma

Gomes,

Costa,

Duarte

et al. 2024

ACS Omega

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Due to the growth in the number of patients and the complexity involved in anticancer therapies, new therapeutic approaches are urgent and necessary. In this context, compounds containing the selenium atom can be employed in developing new medicines due to their potential therapeutic efficacy and unique modes of action. Furthermore, tellurium, a previously unknown element, has emerged as a promising possibility in chalcogen-containing compounds. In this study, 13 target compounds (9a−i, 10a−c, and 11) were effectively synthesized as potential anticancer agents, employing a CuI-catalyzed Csp-chalcogen bond formation procedure. The developed methodology yielded excellent results, ranging from 30 to 85%, and the compounds were carefully characterized. Eight of these compounds showed promise as potential therapeutic drugs due to their high yields and remarkable selectivity against SCC-9 cells (squamous cell carcinoma). Compound 10a, in particular, demonstrated exceptional selectivity, making it an excellent choice for cancer cell targeting while sparing healthy cells. Furthermore, complementing in silico and molecular docking studies shed light on their physical features and putative modes of action. This research highlights the potential of these compounds in anticancer treatments and lays the way for future drug development efforts.

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Quality Evaluation of Calyx of Diospyros Kaki Thunb. by Ultra-High Performance Liquid Chromatography – Mass Spectrometry (UHPLC-MS) Profiling and Fingerprinting and Chemometrics

Yang,

He,

Zhai

et al. 2024

Analytical Letters

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In-vitro antioxidant, lipoxygenase inhibitory, and in-vivo muscle relaxant potential of the extract and constituent isolated from Diospyros kaki (Japanese Persimmon)

Cited by 5 publications

References 32 publications

Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia

Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia

New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma

Quality Evaluation of Calyx of Diospyros Kaki Thunb. by Ultra-High Performance Liquid Chromatography – Mass Spectrometry (UHPLC-MS) Profiling and Fingerprinting and Chemometrics

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