In vitro antioxidant properties of potential biotransformaton products of salicylate, sulphasalazine and aminodypyrine

Wine as a biological fluid: History, production, and role in disease prevention

“…This compound has been described repeatedly in wine (159)(160)(161), at levels of 2.25 mg/L in white wine and at slightly higher concentrations in red wine (162). According to one report (163), the body produces gentisic acid upon absorption of aspirin. Gentisic acid, due to its striking structural similarity with the active principle of salicylic acid (2-hydroxy benzoic acid), would be expected to exert a pharmacological action similar to aspirin: inhibition of the cyclo-oxygenase pathway and vasodilatory effects.…”

“…Gentisic acid, due to its antioxidant activity and its ability to inactivate hydroxyl free radicals (163,165), might also prevent, as has been suggested for aspirin, the development of some forms of cancer (163).…”

“…Indeed, gentisic acid has been prescribed as a substitute for aspirin in clinical medicine (164). The antioxidant activity of this compound has been well established (163,165).…”

A validated HPLC method with electrochemical detection for simultaneous assay of 5‐aminosalicylic acid and its metabolite in human plasma

“…1(a)], is an antiinflammatory drug primarily intended for the therapy of acute bowel disease such as Crohn's disease and ulcerative colitis (Segars et al, 1992;Carpani de Kaski et al, 1993). Many studies have demonstrated that 5-ASA is a very potent free radical scavenger and readily donates its electrons to free radical species, thereby detoxifying these reactive oxygen species (Betts et al, 1985;Ahnfelt-Ronne et al, 1990;Gionchetti et al, 1991). 5-ASA ingested orally in a non-linked, non-protected form is rapidly and extensively absorbed from the proximal part of the gastrointestinal tract.…”

Is local biotransformation the key to understanding the pharmacological activity of salicylates and gold drugs?

“…2. Subsequent oxidation of these di-and poly-hydroxybenzoates which, being reducing agents, destroy reactive oxygen species [13], probably producing ortho and para quinones amongst other products (Fig. 2).…”