In vitro Antioxidant, Xanthine Oxidase and Acetylcholinesterase Inhibitory Activities of Balanites aegyptiaca (L.) Del. (Balanitaceae)

Méda, Nicolas; Lamien-Meda, Aline; Kiendrebéogo, Martin; Lamien, Charles Euloge; Coulibaly, Abou; Millogo‐Rasolodimby, J.; Nacoulma, Odile Germaine

doi:10.3923/pjbs.2010.362.368

Cited by 31 publications

(35 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The above differences in GPx activity could be related to the species and pathogenicity of the parasite and species of the animal. On the contrary to G1 and G3 animals, G2 (infected-BAF-EE-treated) and G4 (BAF-EEtreated only) goats revealed significant elevation in GPx activity which could be attributed to the BAF-EE antioxidant effect [9,71]. Antioxidant enzymes superoxide dismutase and catalase were elevated in mice treated with different parts of B. aegyptiaca extracts [72].…”

Section: Discussionmentioning

confidence: 98%

Therapeutic Effect of Balanites Aegyptiaca Fruit’s Ethanol Extract in Egyptian Baladi Goats Experimentally Infected with Haemonchus Contortus: Blood Serum Biochemical, Oxidative Stress Markers and Pathological Studies

et al. 2020

View full text Add to dashboard Cite

the native breed of goats that is located in the Nile Delta and along the Nile Valley is known as Baladi goats. Amongst other breeds of goats, the Baladi goats have a great economic value [1] and play an essential role in the economy of small, marginal farmers and landless labourers in Egypt [2]. T HE THERAPEUTIC effect of Balanites aegyptiaca fruit's ethanolic extract (BAF-EE) in goats experimentally infected with Haemonchus contortus (H. contortus) was evaluated. Serum biochemical parameters, tissue oxidative stress status and pathological changes were investigated. Twelve goats were divided into 4 equal groups, G1 (infected-untreated), G2 (infected-BAF-EE treated), G3 (infected-albendazole treated) and G4 (uninfected-BAF-EE treated). Infection was conducted at 0-time, whereas treatment with BAF-EE and albendazole was given in the 5 th week post infection (PI). Blood samples were drawn on 0-time, 3 rd week PI and then biweekly till the 9 th week for serum biochemical analyses. At the end of experiment, all animals were slaughtered to estimate oxidative stress markers and histopathological alterations in the abomasal and hepatic tissues. Serum biochemistry of infected animals showed significant depression of total serum proteins, albumin, albumin/ globulin ratio, total antioxidant capacity and calcium levels. The activity of AST, ALT and γGT and the cholesterol, urea and creatinine levels were significantly elevated in the serum of infected animals. Glutathione peroxidase values decreased significantly in tissue homogenate of G1 and G3 goats than those in G2 and G4 goats. Malondialdehyde followed a reverse course. Abomasa of infected animals in G1 revealed inflammation, necrosis, petechial hemorrhages and cellular infiltration. Liver showed bile duct hyperplasia, degeneration of hepatocytes and cell infiltration. Intensity of alterations were lower in infected-treated animals. In conclusion, BAF-EE has hepatoprotective effect and can improve serum biochemical alterations and oxidative stress status in goats infected with H. contortus, justifying its use as a safe natural anthelmintic agent.

show abstract

Section: Discussionmentioning

confidence: 98%

Therapeutic Effect of Balanites Aegyptiaca Fruit’s Ethanol Extract in Egyptian Baladi Goats Experimentally Infected with Haemonchus Contortus: Blood Serum Biochemical, Oxidative Stress Markers and Pathological Studies

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The study also showed that B. aegyptiaca galls and leaves fractions exhibited a moderate xanthine oxidase inhibitory activity compared with the acetylcholinesterase which was weakly inhibited by the tested extracts and fractions. [88]…”

Section: Pharmacological Activitymentioning

confidence: 99%

A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity

Chothani¹,

Vaghasiya²

2011

Phcog Rev

164

113

View full text Add to dashboard Cite

Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature.

show abstract

“…The assay mixture was incubated at 25 ºC for 30 min. The reaction was stopped by adding 1 mL of 1 N HCl and the absorbance was measured at 290 nm using an UV spectrophotometer (19, 20). Allopurinol (5 – 100 μg/mL) was used as the standard.…”

Section: Methodsmentioning

confidence: 99%

In silico docking studies and in vitro xanthine oxidase inhibitory activity of commercially available terpenoids

et al. 2012

View full text Add to dashboard Cite

Objective Xanthine oxidase is a highly versatile enzyme that is widely distributed among different species. The hydroxylation of purines is catalysed by xanthine oxidase and especially the conversion of xanthine to uric acid. Xanthine oxidase inhibitors are much useful, since they possess lesser side effects compared to uricosuric and anti-inflammatory agents. The present study deals with in silico and in vitro xanthine oxidase inhibitory analysis of commercially available terpenoids (bisabolol, Î²-caryophyllene, limonene, and Î±- terpinene). Methods Molecular docking studies were performed using AutoDock 4.2 and in vitro xanthine oxidase inhibitory activity was carried out using xanthine as the substrate. In addition, enzyme kinetics was performed using Lineweaver Burkplot analysis. Allopurinol, a known xanthine oxidase inhibitor was used as the standard. Results The results revealed that bisabolol exhibited a lowest binding energy value of about -7.33 kcal/mol. All other compounds showed binding energy values ranging between -7.33 to -5.87 kcal/mol which was less than the standard (-4.78 kcal/mol). In the xanthine oxidase assay, IC₅₀ value of bisabolol was found to be 34.70 Âµg/ml, whereas that of allopurinol was 8.48 Âµg/ml. All the remaining compounds exhibited IC₅₀ values ranging between 34.70 to 68.45 Âµg/ml.Â In the enzyme kinetic studies, bisabolol, Î²-caryophyllene showed non competitive and Limonene, Î±- terpinene and allopurinol showed competitive type of enzyme inhibition. Conclusion It can be concluded that terpenoids could be a promising remedy for the treatment of gout and related inflammatory disorders. Further in vivo studies are required to develop potential compounds with lesser side effects.

show abstract

In vitro Antioxidant, Xanthine Oxidase and Acetylcholinesterase Inhibitory Activities of Balanites aegyptiaca (L.) Del. (Balanitaceae)

Cited by 31 publications

References 27 publications

Therapeutic Effect of Balanites Aegyptiaca Fruit’s Ethanol Extract in Egyptian Baladi Goats Experimentally Infected with Haemonchus Contortus: Blood Serum Biochemical, Oxidative Stress Markers and Pathological Studies

Therapeutic Effect of Balanites Aegyptiaca Fruit’s Ethanol Extract in Egyptian Baladi Goats Experimentally Infected with Haemonchus Contortus: Blood Serum Biochemical, Oxidative Stress Markers and Pathological Studies

A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity

In silico docking studies and in vitro xanthine oxidase inhibitory activity of commercially available terpenoids

Contact Info

Product

Resources

About