In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

Tran, Quan Hung; Tezuka, Yasuhiro; Ueda, Jun-ichi; Nguyen, Nhan Trung; Maruyama, Yasuhiro; Begum, Khurshida; Kim, Hye Sook; Wataya, Yusuke; Tran, Qui Kim; Kadota, Shigetoshi

doi:10.1016/s0378-8741(03)00045-x

Cited by 101 publications

(58 citation statements)

References 17 publications

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“…It has been reported that, the main constituents secreted from the stem of CF is berberine, a natural isoquinoline alkaloid (Tran et al, 2003). It has been reported that berberine attenuated neuronal damage in ischemia/reperfusion model (Yoo et al, 2006) and enhances neuronal cell survival and differentiation in rat's hippocampus (Lim et al, 2008).…”

Section: Ajptmentioning

confidence: 99%

<i>COSCINIUM FENESTRATUM</i> PROTECTS AGAINST ETHANOL-INDUCED NEURODEGENERATION IN ADULT RAT BRAIN

Phachonpai

Wannanon

Thipkaew

et al. 2012

American Journal of Pharmacology and Toxicology

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Alcoholism is a serious problem throughout the world. Despite intensive efforts to develop novel therapeutics for strategy efficacy against neuronal loss leading to memory impairment in alcoholism is still limited. In view of the pitfalls of psychological dependence and adverse behavioral effects of synthetic drugs, the development of low toxicity and high efficiency medicines derived from natural herbal antioxidants exhibits expansive market prospects. In this respect, Coscinium Fenestratum (C. Fenestratum; CF) could be an attractive candidate as a diet supplement for neuroprotactant against ethanol-induced neurodegeneration. Herein, we determined the neuroprotective effects of CF against ethanol-induced neuronal damage in both hippocampus and cerebral cortex. The stems of CF extract (No. HHP-2-462) were dried, refluxed with ethanoland evaporated with lyophilizer. Extract was gave a yield of 8.53%. The rats were pretreated with the extract at various doses ranging from 5, 10 and 20 mg kg −1 once daily per os, 30 min prior to ethanol administration at a dose of 1.8 g kg −1 via i.p for 14 consecutive days and were evaluated the densities of survival and cholinergic neurons in all areas as mention above by immune histological techniques. CF extract at a dose of 5 mg kg −1 showed the attenuation of the neurotoxicity in all brain areas just mentioned except in the temporal cortex. In addition, it also mitigated the degeneration of cholinergic neurons in all areas of hippocampus except in CA3 region. This study indicated that CF extract consumption may be served as a diet supplement protect against neuronal degeneration resulting from excessive continuous consumption of alcohol. However, further researches about possible active ingredients and pharmacokinetic of the extract are still required before moving forward to clinical trial study.

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Section: Ajptmentioning

confidence: 99%

<i>COSCINIUM FENESTRATUM</i> PROTECTS AGAINST ETHANOL-INDUCED NEURODEGENERATION IN ADULT RAT BRAIN

Phachonpai

Wannanon

Thipkaew

et al. 2012

American Journal of Pharmacology and Toxicology

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“…Ber extracts and decoctions have significant antimicrobial activities. Recent pharmacological studies have shown that Ber also possesses antitumor (Kettmann et al, 2004), anti-HIV (Gudima et al, 1994), antifungal (Vollekova et al, 2003), cardioprotective (Zheng et al, 2003), immunoregulative , antimalarial (Tran et al, 2003), anti-inflammatory , antioxidative (Rockova et al, 2004), cerebroprotective (Ma et al, 1999), antimutagenic (Cernakova et al, 2002), vasorelaxing (Ko et al, 2000), anxiolytic (Peng et al, 2004), and analgesic effects. Ber is generally administered as a chloride or sulfate for clinical applications.…”

mentioning

confidence: 99%

Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry

Zuo

Nakamura²,

Akao³

et al. 2006

Drug Metab Dispos

253

153

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ABSTRACT:Berberine (Ber) and its main metabolites were identified and quantified using liquid chromatography/electrospray ionization/ion trap mass spectrometry. Rat plasma contained the main metabolites, berberrubine, thalifendine, demethyleneberberine, and jatrorrhizine, as free and glucuronide conjugates after p.o. Ber administration. Moreover, the original drug, the four main metabolites, and their glucuronide conjugates were all detected in liver tissues after 0.5 h and in bile samples 1 h after p.o. Ber administration. Therefore, the metabolic site seemed to be the liver, and the metabolites and conjugates were evidently excreted into the duodenum as bile. The pharmacokinetics of Ber and the four metabolites were determined in conventional and pseudo germ-free rats (treated with antibiotics) after p.o. administration with 40 mg/kg Ber. The AUC 0-limt and mean transit time values of the metabolites significantly differed between conventional and pseudo germ-free rats. The amounts of metabolites were remarkably reduced in the pseudo germ-free rats, whereas levels of Ber did not obviously differ between the two groups. The intestinal flora did not exert significant metabolic activity against Ber and its metabolites, but it played a significant role in the enterohepatic circulation of metabolites. In this sense, the liver and intestinal bacteria participate in the metabolism and disposition of Ber in vivo.

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“…According to the authors, because B. pilosa is proven to be active against P. falciparum drugresistant parasites in vitro, and in rodent malaria in vivo, it is a good candidate for pre-clinical tests as a phytotherapeutic agent or for chemical isolation of the active compound(s) with the aim of finding new antimalarial drugs. Studies with plants traditionally used for malaria treatment from various parts of the world (Vietnam, South Africa, and São Tomé and Príncipe) also showed inhibitory activities against chloroquine sensitive or resistant strains of P. falciparum (Tran et al 2003, Nundkumar & Ojewole 2002. Particularly promising results were obtained with extracts of the following species: Coscinium fenestra (whole plant), Psidium guajava (bark), Vangueria infausta (leaf), Struchium spargano-phorum (leaf), Cinchona succirubra (bark), Tithonia diversifolia (shoots), Cedrela odorata (bark), and Pycnanthus angolensis (bark).…”

Section: Ethnobotany and Ethnopharmacologymentioning

confidence: 98%

The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review

Basso

Silva

Fett-Neto

et al. 2005

Mem. Inst. Oswaldo Cruz

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In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

Cited by 101 publications

References 17 publications

<i>COSCINIUM FENESTRATUM</i> PROTECTS AGAINST ETHANOL-INDUCED NEURODEGENERATION IN ADULT RAT BRAIN

<i>COSCINIUM FENESTRATUM</i> PROTECTS AGAINST ETHANOL-INDUCED NEURODEGENERATION IN ADULT RAT BRAIN

Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry

The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review

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