In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid

Banzouzi, Jean-Théophile; Prado, Regilane Matos da Silva; Menan, Hervé; Valentin, Alexis; Roumestan, Caroline; Mallié, M.; Pélissier, Yves; Blache, Yves

doi:10.1016/s0378-8741(02)00121-6

Cited by 101 publications

(79 citation statements)

References 9 publications

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“…Phenolic compounds like ellagic acid and protocatechuic acid have been identified as parts of the constituents of Alchornea cordifolia (Ogungbamila and Samuelsson, 1990;Lamikara et. al;Banzouzi et. al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Jacob

Olaleye

Olugbuyiro

2014

Int J Appl Sci Biotechnol

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Ethnopharmacological relevance: The dry leaf of Alchornea cordifolia (AC) is used, in traditional medicine in the S Nigeria, for the preparation of blood tonic, remedies for urinary, respiratory, liver and gas intestinal disorders. Aim of the study: This study investigated the protective property of AC leaf against liver damage in animals with a view to exploring its use for the treatment of hepatotoxicity in humans. Material and methods: Ethanol extract of A. cordifolia was used to study the hepatoprotective activity in acetaminophen-induced Albino rats (150-200g). Animals in Group 1 served as vehicle control, Group 2 served as hepatotoxin (Acetaminophen 2g/kg treated) group, Groups 3 and 4 served as positive control (Vitamin E and Curcumin 100 mg/kg bw respectively) groups, and Groups 5-8 served as (200-500mg/kg bw) AC leaf extract treated groups while Group 9 served as normal group (AC extract only 300 mg/kg bw). Results: The hepatotoxic group showed hepatocytic necrosis, cellular infiltration and inflammation in the liver. The treatment group restored the liver cells to their normal lobular architecture in a dose dependent manner. The protection offered by the plant extract compared well with the standard antioxidant agents (Curcumin and Vitamin E). Tannins, flavonoids, alkaloids and saponins were detected in the phytochemical screening. Conclusion: Our findings suggest Alchornea cordifolia ethanol leaf extract as promising herpatoprotective herb and give credence to the folkloric use of this plant for the treatment of liver problems.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Jacob

Olaleye

Olugbuyiro

2014

Int J Appl Sci Biotechnol

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“…The cancer-chemopreventive properties of EA have been associated with the inhibition and long-term induction of glutathione S-transferases (GST; EC 2.5.1.18) (5,27,28). In addition to its chemopreventive effects in mammalian systems, EA has been shown to possess antiplasmodial activity in the upper-nanomolar range (2,8,37), which has been linked to the inhibition of plasmepsin II and an impairment of beta-hematin formation in the parasite (8).…”

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confidence: 99%

Compounds Structurally Related to Ellagic Acid Show Improved Antiplasmodial Activity

Sturm

Ying

Zimmermann

et al. 2009

Antimicrob Agents Chemother

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The cancer chemopreventive agent ellagic acid (EA) is a known inhibitor of glutathione S-transferases (GSTs) and possesses antiplasmodial activities in the upper-nanomolar range. In the recent drug development approach, the properties of the active site of Plasmodium falciparum GST were exploited for inhibitor design by introducing one or two additional hydroxyl groups into EA, yielding flavellagic acid (FEA) and coruleoellagic acid (CEA), respectively. Indeed, the inhibition of P. falciparum GST was improved with the increasing hydrophilicity of the planar polyaromatic ring system. Studying the effects of the two compounds on the central redox enzymes of Plasmodium revealed that glutathione reductase and thioredoxin reductase also are inhibited in the lower-micromolar range. Both compounds had strong antiplasmodial activity in the lower-nanomolar range and were particularly effective against chloroquine (CQ)-resistant P. falciparum strains. Neither FEA nor CEA showed cytotoxic effects on human cells. This was supported by negligible changes in transcript levels and enzyme activities of redox enzymes in human A549 cells upon treatment with the compounds. In Plasmodium, however, CEA treatment resulted in a marked downregulation of most antioxidant genes studied and impaired mainly the trophozoite stage of the parasites. In addition, EA, CEA, and FEA were found to strongly inhibit in vitro heme aggregation. In vitro and preliminary in vivo studies indicated that, compared to CQ, CEA is a slowly acting compound and is able to significantly improve the survival of Plasmodium berghei-infected mice. We conclude that FEA and CEA are promising antimalarial compounds that deserve to be studied further.

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“…11,12) The observed effects were correlated with the presence of ellagic acid. 13) In addition to flavonoids with muscle-relaxant activity, Alchornea latifolia contains pentacyclic triterpenoids with cytotoxic activity against the cancer cell lines Hep-G2 and A-431 and potently inhibits topoisomerase II. 14) Sulphated quercetin derivatives with activity against Gram-positive and Gram-negative bacteria as well as against mushrooms were isolated from Alchornea laxiflora.…”

mentioning

confidence: 99%

Constituents and Antiulcer Effect of Alchornea glandulosa: Activation of Cell Proliferation in Gastric Mucosa during the Healing Process

Calvo

Lima

Silva

et al. 2007

Biological & Pharmaceutical Bulletin

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In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid

Cited by 101 publications

References 9 publications

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Compounds Structurally Related to Ellagic Acid Show Improved Antiplasmodial Activity

Constituents and Antiulcer Effect of Alchornea glandulosa: Activation of Cell Proliferation in Gastric Mucosa during the Healing Process

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