In Vitro Antiprotozoal Activity Of Enantia Chlorantha Oliv Stem Bark Used In Nigeria Ethnomedicine

Imieje, V; Fasinu, PS; Jain, S. K.; Tekwani, Babu L.; Khan, Shabana I.; Ali, Zulfiqar; Khan, IA; Falodun, Abiodun

doi:10.1055/s-0036-1578735

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 22. Ficus capensis, T. mollis and F. vogelli leave extracts showed significant (p<0.05) inhibitory activity with IC50 of 343.73±6.13; 344.47±4.66 and 1630.67±2.85 µg/mL, respectively, compared to others.…”

mentioning

confidence: 85%

Effects of Selected Terminalia and Ficus Species in the Inhibition of α-Amylase and α- Glucosidase Enzymes

2023

TJNPR

View full text Add to dashboard Cite

Some Ficus and Terminalia species are relevant in the management of diabetes mellitus but their antidiabetic principles and mechanism of action are yet to be investigated. This study was aimed at investigating the inhibitory potential of ten ethnobotanically selected Ficus and Terminalia species against α-amylase and α-glucosidase enzymes. The methanol extracts of ten selected plants from Ficus and Terminalia genera were tested for their inhibitory activity against porcine pancreatic α-amylase and α-glucosidase from Saccharomyces cerevisiae using colorimetric assay. Acarbose was used as the standard. Percentage inhibition was determined and IC50 value was calculated by analyzing dose-response data using non-linear regression with the aid of GraphPad prism® (7). The result showed that six plant extracts inhibited α-amylase enzyme while all the ten extracts displayed inhibition against glucosidase enzyme in a concentration-dependent manner. Terminalia mollis, F. capensis, and F. vogelli leaf extracts showed significant (p<0.05) inhibitory activity on α-amylase enzyme with IC50 of 344.47±4.66, 343.73±6.13; and 1630.67±2.85 µg/mL, respectively, compared to other extracts. A significant inhibitory activity of these extracts was also observed against α-glucosidase enzyme with IC50 of 6.482±0.61, 11.36±1.01, and 78.47±1.94 µg/mL, respectively, compared to acarbose IC50 2584±9.61 µg/mL. The results from this investigation justify the folkloric usage of these plants for the management of diabetes mellitus. Hence, further investigation is ongoing to isolate and characterize the antidiabetic principles from T. mollis, and F. capensis methanolic leaf extracts.

show abstract

mentioning

confidence: 85%

Effects of Selected Terminalia and Ficus Species in the Inhibition of α-Amylase and α- Glucosidase Enzymes

2023

TJNPR

View full text Add to dashboard Cite

show abstract

“…Total Flavonoid Content (TFC) TFC was determined using a colorimetric method. 24 In a 96-well plate, 100 μL of sample (100 μg/mL in DMSO) or standard quercetin solution and 100 μL of 2% AlCl3 in methanol were added and mixed thoroughly. The reaction mixture was kept at room temperature for 15 min, and the absorbance was recorded at 435 nm.…”

Section: Total Phenolic Content (Tpc)mentioning

confidence: 99%

Antioxidant and Anticancer Activity of Opuntia elatio Mill. Ethanol Extract and the Fractions

2023

TJNPR

View full text Add to dashboard Cite

Several studies showed the analgesic and anti-inflammatory effects of fruit extracts from Opuntia genus. The fruit and young stems have also been traditionally used to treat diabetes, hypertension, asthma, burns, edema, and digestive disorders. 7 Cactus pears are known for the rich array of bioactive components, and phenolic compounds, betasianin, and betaxanthin pigments possessing strong antioxidant properties are identified as the most abundant. Phenolic compounds are substances with an aromatic ring carrying one or more hydroxyl groups, including functional derivatives. Several studies showed that cactaceae plants and fruits contained glycosylated flavonols, dihydroflavonols, flavonones, and flavonols. The antioxidant properties of phenolic compounds in the cactus pear plant make the fruit an essential source for preventing degenerative diseases, such as cancer, diabetes, and hyperglycemia. 8 Opuntia, a sprawling genus of succulent shrubs, has gained popularity in warmer regions across the world due to its unique appearance and attractive flowers. These shrubs are commonly known as Prickly pears due to the edible fruit, and Opuntia elatior Mill. (OpE) has been reported to possess secondary metabolites, such as phenolic and flavonoid compounds. 9 Phenolic compounds, such as delphinidin, petunidin, cyanidin, malvidin, gallic acid, ferulic acid, sinapic acid, pcoumaric acid, hydroxycinnamic acid, vanillic acid, syringic acid, eucomic acid, and chlorogenic acid, have previously been identified in Opuntia spp extracts using LC-MS. [10][11][12] The extract also contains flavonoids, such as apigenin, myricetin, quercetin, kaempferol, isorhamnetin, and cathecin. 13 Phenolic compounds have also been reported to have antioxidant activity and anticancer potential in vitro. According to chemical characterization, these properties can be attributed to the presence of galloyl derivatives, flavan-3-ols, phenolic acids, and flavones/ols. 14 Phenolic compounds are natural antioxidants contained in plant foods, which are usually biosynthesized from phenylalanine or tyrosine through the shikimate acid pathway. 15 Furthermore, these components have the ability to neutralize free radicals by donating electrons or

show abstract

In Vitro Antiprotozoal Activity Of Enantia Chlorantha Oliv Stem Bark Used In Nigeria Ethnomedicine

Cited by 2 publications

References 0 publications

Effects of Selected Terminalia and Ficus Species in the Inhibition of α-Amylase and α- Glucosidase Enzymes

Effects of Selected Terminalia and Ficus Species in the Inhibition of α-Amylase and α- Glucosidase Enzymes

Antioxidant and Anticancer Activity of Opuntia elatio Mill. Ethanol Extract and the Fractions

Contact Info

Product

Resources

About