In vitro antitumor activity of heterochitooligosaccharides (Review)

Ильина, А. В.; Варламов, В. П.

doi:10.1134/s0003683815010068

Cited by 14 publications

(6 citation statements)

References 34 publications

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“…22 Relative viscosities of polymer samples in 0.2M NaAc=2 wt % HAc (v=v 5 1=1) were measured in triplicate using an Ubbelohde capillary viscometer at 25.0 6 0.1 C. The intrinsic viscosity was determined by Huggins and Kraemer plots. M v of chitosan was calculated using the classical MarkHouwink equation [eq.…”

Section: Chitosan Characterizationmentioning

confidence: 99%

Water state in chemically and physically crosslinked chitosan membranes

Ostrowska-Czubenko

Pieróg

Gierszewska

2013

J of Applied Polymer Sci

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Chemically and physically crosslinked chitosan membranes were prepared by treating chitosan (Ch) with glutaraldehyde (GA) and sulfuric acid (SA). FTIR and XRD results were employed to confirm the formation of covalent and ionic crosslinks between Ch, GA, and SA. The states of water in non-crosslinked and covalently and ionically crosslinked chitosan membranes containing different amount of water were investigated by low temperature differential scanning calorimetry measurements. The equilibrium swelling in water was examined gravimetrically. Two types of water were found in the polymer samples, i.e., freezing water and nonfreezing water. The effect of crosslinking process on water state and water uptake was analyzed. The water uptake decreased after chitosan crosslinking with GA, but significantly increased after later crosslinking with SA. The amount of non-freezing water was generally smaller in crosslinked membranes. An impact of molecular and supermolecular structure on water uptake and state of water in non-crosslinked and crosslinked chitosan membranes was discussed.

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Section: Chitosan Characterizationmentioning

confidence: 99%

Water state in chemically and physically crosslinked chitosan membranes

Ostrowska-Czubenko

Pieróg

Gierszewska

2013

J of Applied Polymer Sci

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“…Oligochitosan, a degradation product of chitosan, is mainly derived from the wastes of shellfish and crustaceans; it is composed of homo- or heterooligomers of D -glucosamine and N -acetyl- D -glucosamine . Oligochitosan has much better water solubility than chitosan and, thus, is more suitable and convenient than the latter for practical applications. , Extensive research to investigate the bioactivities of oligochitosan has been performed, and findings indicate that oligochitosans possess abundant functional properties, such as antitumor, antioxidant, and antimicrobial activities. − These bioactivities allow the material to be applied to many fields, such as agriculture, biomedicine, and food . In agriculture, oligochitosans effectively elicit plant innate immunity, promote plant growth, and improve plant tolerance to adverse condition stress.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Oligochitosans on Isoflavone Metabolites, Antioxidant Activity, and Isoflavone Biosynthetic Genes in Soybean (Glycine max) Seeds during Germination

Jia

Zou

et al. 2019

J. Agric. Food Chem.

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Five oligochitosans with increasing degrees of polymerization (DPs), i.e., from chitotriose to chitoheptaose, were examined to clarify the structure−bioactivity relationship between the DPs of oligochitosans and their effects on the isoflavone metabolites, total phenolic and flavonoid contents (TPC and TFC, respectively), and antioxidant activity of soybean (Glycine max) seeds during germination. Oligochitosans of different DPs exhibited varying influences on the TPC, TFC, and antioxidant activities of soybean seeds. Chitohexaose exerted a strong effect and significantly increased the aforementioned parameters in soybean seeds 72 h after germination. Genistin, malonylgenistin, and genistein were the main isoflavones found, and the genistin and genistein contents were significantly enhanced by 67.32% and 131.38%, respectively, after chitohexaose treatment. Several critical genes involved in the isoflavone biosynthesis (i.e., PAL, CHS, CHI, IFS) of soybeans treated with and without chitohexaose were analyzed, and results suggested that chitohexaose application could dramatically stimulate the transcription of these genes.

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“…Degradation of O ‐glycosidic linkages of chitosan produces LMWC with varying degrees of polymerization. These methods include enzymatic hydrolysis, acid‐mediated hydrolysis, ultrasonic degradation, oxidative degradation and chemo‐enzymatic depolymerization…”

Section: Introductionmentioning

confidence: 99%

Effect of degree of deacetylation on solubility of low‐molecular‐weight chitosan produced via enzymatic breakdown of chitosan

Kapadnis

Dey

Dandekar

et al. 2019

Polymer International

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Chitosan has emerged as a unique biomaterial, possessing scope in diverse applications in the biomedical, food and chemical industries. However, its high molecular weight is a concern when handling the polymer. Various techniques have been explored for depolymerization of this polymer, wherein enzymes have emerged as the most economic method having minimum degrading effect on the polymer and resulting in formation of side products. Chitosan can be depolymerized using a broad range of enzymes. In this study, various enzymes like -amylase, papain, pepsin and bromelain were employed to depolymerize chitosan and convert it into its lower molecular weight counterpart. Further, attempts were made to elucidate the process of depolymerization of chitosan, primarily by determining the change in its viscosity and hence its molecular weight. The process of depolymerization was optimized using a one-factor-at-a-time approach. The molecular weight of the resultant chitosan was estimated using gel permeation chromatography and infrared spectroscopy. These studies revealed a considerable decrease in molecular weights of chitosan depolymerized by pepsin, papain, bromelain and -amylase, resulting in recovery of the low-molecular-weight chitosan of 76.09 ± 5, 74.18 ± 5, 55.75 ± 5 and 49.18 ± 5%, respectively. Maximum yield and depolymerization were obtained using pepsin and papain due to their enzymatic recognition pattern, which was also validated using studies involving molecular dynamics.

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In vitro antitumor activity of heterochitooligosaccharides (Review)

Abstract: This review presents an analysis of the literature data over the last decade in order to reveal the relationship between the structure and composition of chitin/chitosan oligomers and their antitumor activity.

Cited by 14 publications

References 34 publications

Water state in chemically and physically crosslinked chitosan membranes

Water state in chemically and physically crosslinked chitosan membranes

Effects of Different Oligochitosans on Isoflavone Metabolites, Antioxidant Activity, and Isoflavone Biosynthetic Genes in Soybean (Glycine max) Seeds during Germination

Effect of degree of deacetylation on solubility of low‐molecular‐weight chitosan produced via enzymatic breakdown of chitosan

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