In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake

Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands

“…[34,35] Nevertheless, one of the main limitations of these compounds is their poor water solubility, which can hinder bioavailability in vivo and lead to complicated formulation protocols. Based on a previous study describing compounds 1-5, [24,25] which contain hydrophilic phosphine ligands, we decided to further investigate the biological properties of these complexes, together with two novel related complexes 6 and 7 ( Figure 1).…”

Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Nonsymmetrically 4‐(Methoxycarbonyl)benzyl‐Substituted N‐Heterocyclic Carbene–Silver Acetate Complexes

“…Zhu et al has reported that silver carboxylate dimers possess anticancer activity against human carcinoma cells [36]. McKeage and co-workers have shown phosphine complexes of silver to be active anticancer agents, even against cisplatin-resistant cell lines [37]. Youngs and coworkers have reported anticancer activities of NHC -silver complexes derived from 4,5-dichloro-1H-imidazole against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and HeLa (cervical) [38].…”

Variable coordination of tris(2-pyridyl)phosphine and its oxide toward M(hfac)2: a metal-specifiable switching between the formation of mono- and bis-scorpionate complexes

“…On the cathodic potential sweep in the solutions of Co II (6) and Ni II (7) complexes at potentials more negative than −0.5 V, the growth of a cathodic current was observed, although there were no cathodic peaks in the studied potential window. Even so, the products of cathodic reduction appeared in the solution and might be responsible for the anodic peak at −0.150/−0.140 V on the anodic branch of the CV.…”

“…Thus, the metal atom adopts a distorted octahedral geometry. It should be noted that in the CuN 6 hydrogen bonds (their parameters are given in the captions of Fig. 4 …”

“…[1][2][3] The combination of "soft" (P-atom) and "hard" (N-atoms) donor sites in pyridylphosphines makes them very important and versatile ligands for the design of unique catalysts, 4 luminescent materials 5 and prospective drugs. 6 Among pyridylphosphines, tris (2-pyridyl) phosphine (Py 3 P) is gaining a special interest owing to the useful properties of its metal complexes. For instance, Pd, 7,8 Cr, 9 Mo, 9 W, 9,10 Ru 11 and Rh, 11 Fe, 12 Co, 12,13 Ni 13 and Mn 13 complexes with Py 3 P have been explored as catalysts for methoxycarbonylation of alkynes, 7,8 Diels-Alder cycloaddition, 9 Friedel-Crafts/aldehyde cyclotrimerization, 10 hydroformylation of alkenes, 11 ethylene polymerization, 12 and O 2 -oxidation of tetraline.…”