In-vitro antiviral activity and in-silico targeted study of quinoline-3-carboxylate derivatives against SARS-Cov-2 isolate

Mittal, Ravi Kumar; Purohit, Priyank; Murugesan, Sankaranarayanan; Muzaffar-Ur-Rehman, Mohammed; Taramelli, Donatella; Signorini, Lucia; Dolci, Maria; Basilico, Nicoletta

doi:10.1007/s11030-023-10703-w

A procedure for temperature-sensitive, fluorescence-active carrageenan nanogel using disoriented conformation of carrageenan with de-solvating agent.

purohit,

Bhatt,

Khailkhura

2023

Preprint

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Polymers, in their grafted and derivatized forms, are frequently used in medical research due to their unique properties as diagnostic, targeted, sustained, and regulated carriers. The method of iota carrageenan nanogel has been developed in this invention. The method is based on solubility, which was first investigated using the solvent screening technique. The de-solvating agent was then used to reduce the particle size and produce the gel in nano form, moreover, the viscosity and other physical properties were evaluated. Furthermore, it was compared to the basic gel, which was formed by adding polymer to hot water without any additional procedures, as opposed to the nano gel. The nanogel has an advantage over the regular gel due to its increased stability, fluorescence activity, and other favorable qualities. The special benefit of nanogel was discovered to be that it is an effective spreader material due to its low gel point and viscosity. The breakthrough technique that depends just on temperature and desolation without the need for crosslinking compounds will be more ecologically friendly and advantageous to polymer scientists, particularly in the domain of medical science.

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A procedure for temperature-sensitive, fluorescence-active carrageenan nanogel using disoriented conformation of carrageenan with de-solvating agent.

purohit,

Bhatt,

Kailkhura

2024

Preprint

Self Cite

1

0

View full text Add to dashboard Cite

Polymers, in their grafted and derivatized forms, are frequently used in medical research due to their unique properties as diagnostic, targeted, sustained, and regulated carriers. The method of iota carrageenan nanogel has been developed in this invention. The method is based on solubility, which was first investigated using the solvent screening technique. The de-solvating agent was then used to reduce the particle size and produce the gel in nano form, moreover, the viscosity and other physical properties were evaluated. Furthermore, it was compared to the basic gel, which was formed by adding polymer to hot water without any additional procedures, as opposed to the nano gel. The nanogel has an advantage over the regular gel due to its increased stability, fluorescence activity, and other favorable qualities. The special benefit of nanogel was discovered to be that it is an effective spreader material due to its low gel point and viscosity. The breakthrough technique that depends just on temperature and desolation without the need for crosslinking compounds will be more ecologically friendly and advantageous to polymer scientists, particularly in the domain of medical science.

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Nitrogen-fused Heterocycles: Empowering Anticancer Drug Discovery

Biswas,

Mittal,

Sharma

et al. 2024

MC

5

0

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The worldwide impact of cancer is further compounded by the constraints of current anticancer medications, which frequently exhibit a lack of selectivity, raise safety apprehensions, result in significant adverse reactions, and encounter resistance mechanisms. The current situation highlights the pressing need to develop novel and more precise anticancer agents that prioritize safety and target specificity. Remarkably, more than 85% of drugs with physiological activity contain heterocyclic structures or at least one heteroatom. Nitrogen-containing heterocycles hold a significant position among these compounds, emerging as the most prevalent framework within the realm of heterocyclic chemistry. This article explores the medicinal chemistry behind these molecules, highlighting their potential as game-changing possibilities for anticancer medication development. The analysis highlights the inherent structural variety in nitrogen-containing heterocycles, revealing their potential to be customized for creating personalized anticancer medications. It also emphasizes the importance of computational techniques and studies on the relationships between structure and activity, providing a road map for rational medication design and optimization. Nitrogen-containing heterocycles are a promising new area of study in the fight against cancer, and this review summarises the state of the field so far. By utilizing their inherent characteristics and exploiting cooperative scientific investigations, these heterocyclic substances exhibit potential at the forefront of pioneering therapeutic approaches in combating the multifaceted obstacles posed by cancer.

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In-vitro antiviral activity and in-silico targeted study of quinoline-3-carboxylate derivatives against SARS-Cov-2 isolate

Cited by 5 publications

References 57 publications

A procedure for temperature-sensitive, fluorescence-active carrageenan nanogel using disoriented conformation of carrageenan with de-solvating agent.

A procedure for temperature-sensitive, fluorescence-active carrageenan nanogel using disoriented conformation of carrageenan with de-solvating agent.

A procedure for temperature-sensitive, fluorescence-active carrageenan nanogel using disoriented conformation of carrageenan with de-solvating agent.

Nitrogen-fused Heterocycles: Empowering Anticancer Drug Discovery

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