In-vitro Antiviral Activity of a Novel Phthalic Acid Ester Derivative Isolated from the Bangladeshi Mangrove Fern Acrostichum aureum

Uddin, Shaikh Jamal; Bettadapura, Jayaram; Guillon, Patrice; Grice, I. Darren; Mahalingam, Suresh; Tiralongo, Evelin

doi:10.4172/jaa.1000078

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…These phytochemicals are aferoside C, suginal, dibutyl phthalate, nerolidol, and alphaterpinene. Phthalic acid esters may have antiviral activity as demonstrated for 2"-(methoxycarbonyl)-5"-methylpentyl 2'-methylhexyl phthalate from the aerial parts of the Bangladeshi mangrove fern Acrostichum aureum, which was found to show antiviral activity against dengue, chikungunya, and human parainfluenza virus (Uddin et al, 2013). Any antiviral activities of the other four compounds have not been reported to our knowledge.…”

Section: Physico-chemical Properties Of Selected Phytochemicals and Adme Analysismentioning

confidence: 81%

Can Costus afer be used for co-treatment of COVID-19, its symptoms and comorbidities? A novel approach for combating the pandemic and implications for sub-Saharan Africa

Jannat¹

2021

Trop Biomed

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Despite the huge loss of lives and massive disruption of the world economy by the COVID-19 pandemic caused by SARS-CoV-2, scientists are yet to come out with an effective therapeutic against this viral disease. Several vaccines have obtained 'emergency approval', but difficulties are being faced in the even distribution of vaccines amongst high-and lowincome countries. On top of it, comorbidities associated with COVID-19 like diabetes, hypertension and malaria can seriously impede the treatment of the main disease, thus increasing the fatality rate. This is more so in the context of sub-Saharan African and south Asian countries. Our objective was to demonstrate that a single plant containing different phytoconstituents may be used for treatment of COVID-19 and comorbidities. Towards initial selection of a plant, existing scientific literature was scanned for reported relevant traditional uses, phytochemicals and pharmacological activities of a number of plants and their phytoconstituents pertaining to treatment of COVID-19 symptoms and comorbidities. Molecular docking studies were then performed with phytochemicals of the selected plant and SARS-CoV-2 components -Mpro, and spike protein receptor binding domain and hACE2 interface using AutoDock V ina. We showed that crude extracts of an indigenous African plant, Costus afer having traditional antidiabetic and antimalarial uses, has phytochemicals with high binding affinities for Mpro, and/or spike protein receptor binding domain and hACE2 interface; the various phytochemicals with predicted high binding energies include aferoside C, dibutyl phthalate, nerolidol, suginal, and ±-terpinene, making them potential therapeutics for COVID-19. The results suggest that crude extracts and phytochemicals of C. afer can function as a treatment modality for COVID-19 and comorbidities like especially diabetes and malaria.

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Section: Physico-chemical Properties Of Selected Phytochemicals and Adme Analysismentioning

confidence: 81%

Can Costus afer be used for co-treatment of COVID-19, its symptoms and comorbidities? A novel approach for combating the pandemic and implications for sub-Saharan Africa

Jannat¹

2021

Trop Biomed

View full text Add to dashboard Cite

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In-vitro Antiviral Activity of a Novel Phthalic Acid Ester Derivative Isolated from the Bangladeshi Mangrove Fern Acrostichum aureum

Cited by 1 publication

References 37 publications

Can Costus afer be used for co-treatment of COVID-19, its symptoms and comorbidities? A novel approach for combating the pandemic and implications for sub-Saharan Africa

Can Costus afer be used for co-treatment of COVID-19, its symptoms and comorbidities? A novel approach for combating the pandemic and implications for sub-Saharan Africa

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