In-vitro antiviral activity of Carica papaya formulations against dengue virus type 2 and chikungunya virus

Patil, Poonam; Alagarasu, Kalichamy; Chowdhury, Dr Sukanta; Kakade, Mahadeo; Cherian, Sarah; Yadav, Jp; Kaushik, Samander; Parashar, Deepti

doi:10.1016/j.heliyon.2022.e11879

Cited by 13 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We evaluated the in vitro antiviral activity (on Vero CCL-81 cells) of certain papaya-based tonics/drugs commercially available in the market to treat thrombocytopenia in DENV infection. The results revealed that there was no significant reduction in virus titre in drug-treated cells compared to virus control 35 . It is possible that the methods used to prepare these commercial products may not lead to the extraction of possible antiviral agents present in the CPLE but may be sufficient to retain the agents involved in immunomodulation.…”

mentioning

confidence: 85%

Antiviral & platelet-protective properties of Carica papaya in dengue

Shrivastava

Alagarasu

Cherian

et al. 2022

Indian Journal of Medical Research

View full text Add to dashboard Cite

mentioning

confidence: 85%

Antiviral & platelet-protective properties of Carica papaya in dengue

Shrivastava

Alagarasu

Cherian

et al. 2022

Indian Journal of Medical Research

View full text Add to dashboard Cite

“…Carica papaya (Caricaceae) has been explored for various biological activities. The different parts of C. papaya having anticancer, antidiabetic, wound healing, antiulcer, larvicidal, antioxidant, and anti-inflammatory components like flavonoids and phenolic compounds are particularly used for heavy metal toxicity because the flavonoids act as both antioxidants and chelating agents. − The chelating property of flavonoids reduces the bioavailability of heavy metals in biological tissues. − …”

Section: Introductionmentioning

confidence: 99%

Mercuric Chloride Induced Nephrotoxicity: Ameliorative Effect of Carica papaya Leaves Confirmed by Histopathology, Immunohistochemistry, and Gene Expression Studies

Maria Francis,

Karunakaran,

Ashfaq

et al. 2023

ACS Omega

View full text Add to dashboard Cite

The present study analyzes the efficacy of the ethanolic extract of C. papaya leaves (ECP) against HgCl 2 -induced nephrotoxicity. The effects on the biochemical and percentage of body and organ weight against HgCl 2 -induced nephrotoxicity in female Wistar rats were studied. Wistar rats were divided into five groups with six animals in each group: control, HgCl 2 (2.5 mg/kg b.w.), N-acetylcysteine (NAC 180 mg/kg) + HgCl 2 , ECP (300 mg/kg b.w.) + HgCl 2 , and ECP (600 mg/kg) + HgCl 2 groups. After 28 days of study, animals were sacrificed on the 29th day to harvest the blood and kidneys for further analysis. The effect ECP was analyzed by immunohistochemistry (NGAL) and real-time PCR (KIM-1 and NGAL mRNA) in HgCl 2 -induced nephrotoxicity. The results revealed that the HgCl 2 group showed prominent damage in the proximal tubules and glomerulus of nephrons and enormous expression of NGAL in immunohistochemistry and KIM-1 and NGAL in real-time PCR compared to the control group. The simultaneous pretreatment with NAC (180 mg/kg) and ECP (600 and 300 mg/kg) reduced renal damage and expression of NGAL in immunohistochemistry and KIM-1 and NGAL gene in real-time PCR. This study attests to the nephroprotective effect of ECP against HgCl 2 -induced toxicity.

show abstract

“…Among these bioactive compounds are polysaccharides, alkaloids, terpenoids, terpenes, and flavonoids [ 4 ]. Interestingly, medicinal plants have showcased superior anti-DENV and CHIKV activity when compared to their synthetic counterparts [ 5 ]. The exploration of natural products is poised to become a preferred avenue for the development of novel therapeutics.…”

Section: Introductionmentioning

confidence: 99%

“…In in vitro tests involving THP-1 cells treated with papaya leaf extract (PLE), the antiviral activity was evident, leading to a notable reduction in viral load and an increase in the expression of type I interferon (IFN- α ) [ 5 ]. Through in vivo studies conducted on DENV-infected mice, the treatment with papaya plant leaf extract demonstrated the modulation of genes related to regulating endothelial permeability in the liver [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective

Kamaraj,

Ragavendran,

Prem

et al. 2023

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Malaria, a highly perilous infectious disease, impacted approximately 230 million individuals globally in 2019. Mosquitoes, vectors of over 10% of worldwide diseases, pose a significant public health menace. The pressing need for novel antimalarial drugs arises due to the imminent threat faced by nearly 40% of the global population and the escalating resistance of parasites to current treatments. This study comprehensively addresses prevalent parasitic and viral illnesses transmitted by mosquitoes, leading to the annual symptomatic infections of 400 million individuals, placing 100 million at constant risk of contracting these diseases. Extensive investigations underscore the pivotal role of traditional plants as rich sources for pioneering pharmaceuticals. The latter half of this century witnessed the ascent of bioactive compounds within traditional medicine, laying the foundation for modern therapeutic breakthroughs. Herbal medicine, notably influential in underdeveloped or developing nations, remains an essential healthcare resource. Traditional Indian medical systems such as Ayurveda, Siddha, and Unani, with a history of successful outcomes, highlight the potential of these methodologies. Current scrutiny of Indian medicinal herbs reveals their promise as cutting-edge drug reservoirs. The propensity of plant-derived compounds to interact with biological receptors positions them as prime candidates for drug development. Yet, a comprehensive perspective is crucial. While this study underscores the promise of plant-based compounds as therapeutic agents against malaria and dengue fever, acknowledging the intricate complexities of drug development and the challenges therein are imperative. The journey from traditional remedies to contemporary medical applications is multifaceted and warrants prudent consideration. This research aspires to offer invaluable insights into the management of malaria and dengue fever. By unveiling plant-based compounds with potential antimalarial and antiviral properties, this study aims to contribute to disease control. In pursuit of this goal, a thorough understanding of the mechanistic foundations of traditional antimalarial and antidengue plants opens doors to novel therapeutic avenues.

show abstract

In-vitro antiviral activity of Carica papaya formulations against dengue virus type 2 and chikungunya virus

Cited by 13 publications

References 26 publications

Antiviral & platelet-protective properties of Carica papaya in dengue

Antiviral & platelet-protective properties of Carica papaya in dengue

Mercuric Chloride Induced Nephrotoxicity: Ameliorative Effect of Carica papaya Leaves Confirmed by Histopathology, Immunohistochemistry, and Gene Expression Studies

Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective

Contact Info

Product

Resources

About