In Vitro Approach to investigating the phototoxicity of the diuretic drug triamterene

Vargas, Franklin; Fuentes, Alberto; Sequera, J; Méndez, H; Fraile, Germán; Velásquez, Mait; Medina, Rafael

doi:10.1016/s0887-2333(98)00057-5

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…To investigate its capacity as antioxidant, DIP was used as a preservative in the known photohemolysis process induced by triamterene (Vargas and Fuentes 1997;Vargas et al 1998b). The photohemolysis process was reduced to 50% and 67% at concentrations of 1.0 £ 10 ¡6 M and 1.0 £ 10 ¡5 M of DIP, respectively (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

“…Our results suggest that the DIP properties as a protector against 1 O 2 photohemolysis mediated by other phototoxic compounds such as triamterene may be due to an alternative mechanism whereby DIP may function as a quencher of triamterene consisting of a uorescence energy transfer. The relative quantum yields of uorescence of DIP at room temperature was 8 F D 0.23 (¸e x D 305 nm, emit D 483 nm) (Vargas et al 1998b;Iuliano et al 2000). We should also add that therapeutically relevant concentrations are below the level associated with photohemolysis.…”

Section: Discussionmentioning

confidence: 97%

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In Vitro Antioxidant and Photo-oxidant Properties of Dipyridamole

et al. 2001

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The in vitro antioxidant and photo-oxidant activity of dipyridamole was studied by its effect on superoxide- and singlet oxygen-mediated photohemolysis and viability of neutrophils. Dipyridamole was found to be phototoxic when examined by the photohemolysis on human erythrocytes and on linoleic acid as lipid peroxidation model at concentrations above 3.0 x 10(-5) M. On the contrary, when lower concentrations (1.0 x 10(-5) to 1.0 x 10(-6) M) were used, dipyridamole showed a protector action against singlet oxygen-mediated photohemolysis by other phototoxic compounds like triamterene. This antioxidant property is proposed to result from quenching of triamterene mediated by fluorescence energy transfer. Auto-oxidation and fluorescence-energy transfer is clearly an important mechanism for protection for this drug.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

In Vitro Antioxidant and Photo-oxidant Properties of Dipyridamole

et al. 2001

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“…LC/UV was also used to quantify the FA trapped in photochemical studies of a phototoxic muscle relaxant drug [13]. LC is the recommended method for furanic compounds in electrical insulating liquids [14].…”

Section: Introductionmentioning

confidence: 99%

Determination of free furfuryl alcohol in foundry resins by chromatographic techniques

Oliva-Teles

Delerue–Matos

Alvim-Ferraz

2005

Analytica Chimica Acta

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Two chromatographic methods, gas chromatography with flow ionization detection (GC-FID) and liquid chromatography with ultraviolet detection (LC-UV), were used to determine furfuryl alcohol in several kinds of foundry resins, after application of an optimised extraction procedure. The GC method developed gave feasibility that did not depend on resin kind. Analysis by LC was suitable just for furanic resins. The presence of interference in the phenolic resins did not allow an appropriate quantification by LC. Both methods gave accurate and precise results. Recoveries were >94%; relative standard deviations were ≤7 and ≤0.3%, respectively for GC and LC methods. Good relative deviations between the two methods were found (≤3%).

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Mechanistic Studies on the Photochemistry and Phototoxicity of Diuretic Drugs

Vargas¹,

Rivas²

2003

CRC Handbookof Organic Photochemistry and Photobiology, Volumes 1 &Amp; 2, Second Edition

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In Vitro Approach to investigating the phototoxicity of the diuretic drug triamterene

Cited by 3 publications

References 16 publications

In Vitro Antioxidant and Photo-oxidant Properties of Dipyridamole

In Vitro Antioxidant and Photo-oxidant Properties of Dipyridamole

Determination of free furfuryl alcohol in foundry resins by chromatographic techniques

Mechanistic Studies on the Photochemistry and Phototoxicity of Diuretic Drugs

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