In vitro assessment of mitral valve function in cyclically pressurized porcine hearts

Vismara, Riccardo; Leopaldi, Alberto Maria; Piola, Marco; Asselta, Chiara; Lemma, Massimo; Antona, Carlo; Redaelli, Alberto; Vosse, F.N. van de; Rutten, Marcel; Fiore, Gianfranco Beniamino

doi:10.1016/j.medengphy.2016.01.007

Cited by 22 publications

(18 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hemodynamic performance of this simulator has been validated to provide near normal mitral valve function that is representative of in vivo conditions. 4 In addition, physiologic leaflet coaptation was demonstrated without mitral insufficiency, unless there was previous chordal disruption. Although this biosimulator was used to recapitulate mitral valve dysfunction requiring valve repair, the platform can model other heart valve structural changes and can be used with other devices.…”

Section: Commentmentioning

confidence: 99%

“…For this reason, new generations of simulators that use biological organs have emerged that recreate realistic anatomic and hemodynamic cardiac conditions. [1][2][3][4][5][6][7] Herein, we describe a dynamic heart simulator (LifeTec Group, Inc, Eindhoven, The Netherlands) that presents an effective method for learning and perfecting intracardiac valve procedures that require Cartesian X-Y-Z plane navigation with proficiency in hand/eye coordination. This dynamic ex vivo beating heart biosimulator combines the benefits of real-time echocardiographic imaging, videoscopic vision, and hemodynamic changes during off-pump mitral valve repairs via the use of extruded polytetrafluoroethylene (ePTFE) artificial chord implantations.…”

Section: See Editorial Commentary Page 156mentioning

confidence: 99%

“…The current system allows for continual echocardiographic and videoscopic cardiac valve visualization and also is compatible with fluoroscopy. [2][3][4] In addition, this platform can be connected to patient-specific vascular models to replicate many transcatheter procedures. The hemodynamic performance of this simulator has been validated to provide near normal mitral valve function that is representative of in vivo conditions.…”

Section: Commentmentioning

confidence: 99%

See 2 more Smart Citations

The dynamic cardiac biosimulator: A method for training physicians in beating-heart mitral valve repair procedures

Leopaldi¹,

Wróbel²,

Speziali³

et al. 2018

The Journal of Thoracic and Cardiovascular Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Commentmentioning

confidence: 99%

Section: See Editorial Commentary Page 156mentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

The dynamic cardiac biosimulator: A method for training physicians in beating-heart mitral valve repair procedures

Leopaldi¹,

Wróbel²,

Speziali³

et al. 2018

The Journal of Thoracic and Cardiovascular Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…1) of Sorin Biomedica Cardio (Italy). Transplantation of such a valve with a diameter d  25 mm is performed mainly in the left ventricle of the heart with aortic or mitral valve prosthetics [13,14]. In research, a mechanical bileaflet valve was placed in the mitral valve position between the left atrium and the left ventricular chamber.…”

Section: Experimental Setup and Research Techniquementioning

confidence: 99%

Effect of Fluid Viscosity on Noise of Bileaflet Prosthetic Heart Valve

Voskoboinick¹,

Redaelli²,

Chertov³

et al. 2017

Research Bulletin of the National Technical University of Ukraine "Kyiv Politechnic Institute"

Self Cite

View full text Add to dashboard Cite

Background. Numerical simulation and experimental research have been used as powerful tools to understand and predict the behavior and mechanics of the operation of natural heart valves and their prostheses in natural and pathological conditions. Such studies help to evaluate the effectiveness of the valves, their design and the results of surgical procedures, to diagnose healthy and impaired function of the heart valves. There is an actual problem in creating more reliable methods and tools for the operation diagnostics of mechanical heart valves. Objective. The aim of the research is to investigate the effect of fluid viscosity on the hydroacoustic characteristics of jets that flow from a semi-closed and open mechanical bileaflet heart valve. To study the possibility of using hydroacoustic measuring instruments as diagnostic equipment for determining the working conditions of the bileaflet prosthetic heart valve. Methods. The experimental research was carried out by means of hydroacoustic measurements of the hydrodynamic noise in the near wake of the side and central jets of the glycerin solution and the pure water flow downstream of the prosthetic bileaflet heart valve. Results. The effect of fluid viscosity on the hydroacoustic characteristics of the jets that flow from a semi-closed and open mechanical bileaflet heart valve has been experimentally determined. Integral and spectral characteristics of the hydrodynamic noise of jets of the glycerin solution and the pure water flow downstream of the bileaflet mitral heart valve for different fluid rate were detected. Conclusions. In the stream conditions of pure water, the integral characteristics of the pressure field are lower than in stream conditions of the aqueous glycerin solution. As the glycerin concentration in the solution increases, increase average pressures and especially RMS pressure fluctuations. The spectral levels of the hydrodynamic noise in the near wake of the side jet of the glycerin solution are lower than for water flow in the frequency ranges from 1 to 7-8 Hz and from 100 to 1000 Hz for fluid rate 5 l/min. For higher fluid rates, the spectral components of the hydrodynamic noise in the near wake of the side jet of the glycerin solution of the semi-closed mitral valve are higher than that for the pure water. The greatest difference (1.5-1.8 times) in the spectral levels is observed in the frequency range from 10 to 100 Hz for the fluid rate 15 l/min.

show abstract

“…However, it needs to be taken into account that the mock host valves did not model the physiological contraction, and cordae tendineae and papillary muscles were absent. Ex vivo isolated beating heart or pressurised animal heart platforms17,57 and acute in animal trials could provide more reliable insights on the fitting and performance of a transcatheter valve 44. These studies would also be essential to verify the efficacy of the anchoring mechanism to avoid left ventricular outflow tract obstruction by preventing the systolic motion of the native anterior leaflet.…”

Section: Discussionmentioning

confidence: 99%

Design, Analysis and Testing of a Novel Mitral Valve for Transcatheter Implantation

et al. 2017

View full text Add to dashboard Cite

Mitral regurgitation is a common mitral valve dysfunction which may lead to heart failure. Because of the rapid aging of the population, conventional surgical repair and replacement of the pathological valve are often unsuitable for about half of symptomatic patients, who are judged high-risk. Transcatheter valve implantation could represent an effective solution. However, currently available aortic valve devices are inapt for the mitral position. This paper presents the design, development and hydrodynamic assessment of a novel bi-leaflet mitral valve suitable for transcatheter implantation. The device consists of two leaflets and a sealing component made from bovine pericardium, supported by a self-expanding wireframe made from superelastic NiTi alloy. A parametric design procedure based on numerical simulations was implemented to identify design parameters providing acceptable stress levels and maximum coaptation area for the leaflets. The wireframe was designed to host the leaflets and was optimised numerically to minimise the stresses for crimping in an 8 mm sheath for percutaneous delivery. Prototypes were built and their hydrodynamic performances were tested on a cardiac pulse duplicator, in compliance with the ISO5840-3:2013 standard. The numerical results and hydrodynamic tests show the feasibility of the device to be adopted as a transcatheter valve implant for treating mitral regurgitation.Electronic supplementary materialThe online version of this article (doi:10.1007/s10439-017-1828-2) contains supplementary material, which is available to authorized users.

show abstract

In vitro assessment of mitral valve function in cyclically pressurized porcine hearts

Cited by 22 publications

References 17 publications

The dynamic cardiac biosimulator: A method for training physicians in beating-heart mitral valve repair procedures

The dynamic cardiac biosimulator: A method for training physicians in beating-heart mitral valve repair procedures

Effect of Fluid Viscosity on Noise of Bileaflet Prosthetic Heart Valve

Design, Analysis and Testing of a Novel Mitral Valve for Transcatheter Implantation

Contact Info

Product

Resources

About