In-vitro assessment of oxidative stress generated by orthodontic archwires

Špalj, Stjepan; Zrinski, Magda Mlacović; Spalj, Vedrana Tudor; Buljan, Zorana Ivanković

doi:10.1016/j.ajodo.2011.11.020

Cited by 35 publications

(28 citation statements)

References 28 publications

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“…In our study, any difference in cell viability levels was found between ion-implanted and nonimplanted archwires, and these findings suggest that the rhodium layer does not limit the release of metal ions in solution, as was reported in a previous study. 21 EverWhite, BioCosmetic, and Titanol Cosmetic were the polymer-coated NiTi archwires evaluated. Significantly lower cell viability levels were found for EverWhite and BioCosmetic compared to Titanol Cosmetic on day 30.…”

Section: Discussionmentioning

confidence: 99%

In vitro biocompatibility of nickel-titanium esthetic orthodontic archwires

Rongo

Valletta

Bucci

et al. 2016

The Angle Orthodontist

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Objective: To investigate the cytotoxicity of nickel-titanium (NiTi) esthetic orthodontic archwires with different surface coatings. Materials and Methods: Three fully coated, tooth-colored NiTi wires (BioCosmetic, Titanol Cosmetic, EverWhite), two ion-implanted wires (TMA Purple, Sentalloy High Aesthetic), five uncoated NiTi wires (BioStarter, BioTorque, Titanol Superelastic, Memory Wire Superelastic, and Sentalloy), one b-titanium wire (TMA), and one stainless steel wire (Stainless Steel) were considered for this study. The wire samples were placed at 37uC in airtight test tubes containing Dulbecco's Modified Eagle's Medium (0.1 mg/mL) for 1, 7, 14, and 30 days. The cell viability of human gingival fibroblasts (HGFs) cultured with this medium was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Data were analyzed by a twoway analysis of variance (a 5 .05). Results: The highest cytotoxic effect was reached on day 30 for all samples. The archwires exhibited a cytotoxicity on HGFs ranging from "none" to "slight," with the exception of the BioTorque, which resulted in moderate cytotoxicity on day 30. Significant differences were found between esthetic archwires and their uncoated pairs only for BioCosmetic (P 5 .001) and EverWhite (P , .001). Conclusions: Under the experimental conditions, all of the NiTi esthetic archwires resulted in slight cytotoxicity, as did the respective uncoated wires. For this reason their clinical use may be considered to have similar risks to the uncoated archwires. (Angle Orthod. 2016;86:789-795.)

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Section: Discussionmentioning

confidence: 99%

In vitro biocompatibility of nickel-titanium esthetic orthodontic archwires

Rongo

Valletta

Bucci

et al. 2016

The Angle Orthodontist

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“…[3][4][5][6][7] Changes in surface composition (for improved esthetic or reduced friction) could affect wires' roughness parameters 8,9 and working and corrosive properties, [10][11][12][13] and as a result, archwires could behave differently within the oral cavity. 14,15 The surface roughness of archwires in orthodontics is still considered a controversial parameter as far as its relation to friction and corrosion are concerned as well as its relation to clinical use. 5,[16][17][18] Uncoated NiTi wires have titanium oxides (TiO x ) as anticorrosive components; rhodium-coated NiTi (Rh NiTi) has gold and rhodium in a 0.5-mm thin layer (as stated by the manufacturer).…”

Section: Introductionmentioning

confidence: 99%

“…It is common to perform in vitro studies of corrosion processes using electrochemical methods [5][6][7]17,18,21,22 because the release of metal ions within the oral cavity occurs over a long period and is associated with discoloration of adjacent structures and teeth as well as allergic and toxic reactions. 14,15 Electrochemical impedance spectroscopy (EIS) testing determines the polarization resistance, a direct measure of corrosion resistance; cyclic polarization testing helps in the observation of the pitting tendencies of the alloy; and in vitro anodic polarization studies simulate the natural corrosion mechanism that usually happens over a protracted duration of time. With all of these reasons taken into account, clinicians should be informed about limitations and potential risks when using various materials.…”

Section: Introductionmentioning

confidence: 99%

Influence of surface layer on mechanical and corrosion properties of nickel-titanium orthodontic wires

Katić

Ćurković

Semenski

et al. 2014

The Angle Orthodontist

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To analyze the effect of various coating formulations on the mechanical and corrosion properties of nickel-titanium (NiTi) orthodontic wires. Materials and Methods: Uncoated, rhodium-coated, and nitrified NiTi wires were observed with a three-point-bend test, surface roughness (Ra) measurement, scanning electron microscopy, energy dispersive spectroscopy, and electrochemical testing (open circuit potential, electrochemical impedance spectroscopy, and cyclic polarization scan). Differences in the properties of tested wire types were analyzed with analysis of variance and Tukey post hoc test. Results: Uncoated and nitrified NiTi wires showed similar mechanical and anticorrosive properties, while rhodium-coated NiTi wires showed the highest Ra and significantly higher modulus of elasticity, yield strength, and delivery of forces during loading but not in unloading. Rhodium-coated NiTi wires also had the highest corrosion current density and corrosion potential, lowest impedance modulus, and two time constants on Bode plot, one related to the Rh/Au coating and the other to underlying NiTi. Conclusion: Working properties of NiTi wires were unaffected by various coatings in unloading. Nitrification improved corrosion resistance. Rhodium coating reduced corrosion resistance and pronounced susceptibility to pitting corrosion in artificial saliva because of galvanic coupling between the noble coating and the base alloy.

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“…Bu harabiyet, hücrelerde DNA hasarına sebep olarak gerçekleşmekte ve bu durum da hücresel DNA tamir mekanizmalarıyla giderilmektedir. 4 Yani bu defans mekanizmaları reaktif oksijen türlerinin artmış üretimi sonucu baskılanırsa, karsinogenezis mekanizmasına bağlantılı olarak oksidatif stres oluşmaktadır. 3 Günümüzde teknolojik ürünlerin hızla artması ve bu ürünlerin kullanımı ile vücuttaki (hatta oral kavitedeki) oksidatif stresin arttığını bildiren birçok çalışma bulunmaktadır.…”

Section: Introductionunclassified

“…Otoklavlama sırasında ark tellerinin kalitesinin ve karakteristiklerinin etkilenebildiği ve oksidasyona daha eğilimli hale geldiği de rapor edilmiştir. 4 Ancak konuyla ilgili yapılmış olan çalışmalarda, tellerin zamanla deforme olmasının ve PH değişimleri gibi klinik koşulların yeteri kadar taklit edilemediği belirtilmiştir. Genel olarak biyolojik dokularla veya sıvılarla kontak halinde yerleştirilen materyaller için, PH dalgalanmaları veya sıcaklık değişiklikleri gibi lokal mikro-çevresel faktörler tarafından oluşturulan organometalik bileşik oluşumları alaşımın korozyon miktarını arttırabilmektedir.…”

Section: Introductionunclassified

Ortodonti̇de Kullanilan Malzemeleri̇n Si̇totoksi̇si̇tesi̇ni̇n Değerlendi̇ri̇lmesi̇

Karakaş¹,

Esenlik²

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZETHastaların güvenli tedavisini sağlamak için, dental materyallerin sitotoksisitesini tanımlamak çok önemlidir. Sitotoksisite, çeşitli makromoleküllerin sentezlenmesinin engellenmesi sonucu hücrenin fonksiyonlarında ve yapısında hasar meydana gelmesidir. Sitotoksisite mekanizmaları; oksidatif stres ve korozyon odaklıdır. Oksidatif stres mekanizması serbest radikal üretimi ve DNA hasarı sonucu mutasyonlar ile, korozyon ise metal iyon salınımı ile etki göstermektedir. Ortodontide en sık kullanılan materyaller; ark telleri, braketler, rezin adezivler ve bonding ajanlar, mini implantlar, akrilik rezinler, elastomerik maddeler, cam iyonomer simanlar, lehim alaşımlar, magnetler ve invisalign apareylerdir. Bu materyallerin biyo-uyumlulukları metal kompozisyonuna, ısıl işlem görüp görmediğine, üretim yöntemine veya polimerizasyon derecesine bağlıdır. Bu nedenle ortodontik malzemeler sitotoksisite ve iyon salınımı açısından iyi değerlendirilmeli ve sitotoksik özellikleri azaltmak için bazı önlemler alınmalıdır. Anahtar Kelimeler: Ortodontik materyal, biyouyumluluk, sitotoksisite GİRİŞGelişen teknoloji ile birlikte ortodontik malzemelerin çeşitliliği de artmış ve alternatif birçok sistem geliştirilmiştir. Bu sistemlerin kullanımında hastaların güvenli tedavisini sağlamak için, dental materyallerin biyo-uyumluğunu ve olası sitotoksisitesini tanımlamak çok önemlidir. Sitotoksisite, moleküler olaylar sonucu çeşitli makromoleküllerin sentezlenmesinin engellen- ABSTRACTThe defining the cytotoxicity of dental materials is of great important to ensure the safe treatment of patients. Cytotoxicity is defined as damaging the cell structure and function as a result of inhibition of the synthesis of various macromolecules. Cytotoxicity mechanisms are focused on oxidative stress and corrosion. Mechanisms of oxidative stress show effects as mutations resulted from free radicals production and DNA damage; mechanism of corrosion exhibits metal ion release as well. The most common materials used in orthodontics are; arch wires, brackets, adhesives and resin bonding agents, mini implants, acrylic resins, elastomeric materials, glass ionomer cements, solder alloys, magnets and Invisalign appliances. Biocompatibility of these materials depends on the metal composition,whether they are exposed to heat process, production method of them or the degree of polimerization of it. Therefore orthodontic materials should be considered in terms of cytotoxicity and ion release and certain measures should be taken for decreasing cytotoxic properties. Key-words: Orthodontic materials, bio-compatibility, cytotoxicity. mesi ve buna bağlı olarak hücrenin fonksiyonlarında ve yapısında belirgin hasarlar meydana gelmesi olarak tanımlanır.1 Sitotoksisite mekanizmaları daha çok 1) oksidatif stres ve 2) korozyon üzerinde odaklanmaktadır. Oksidatif stres mekanizması serbest radikal üretimi ve DNA hasarı sonucu mutasyonlar ile, korozyon ise metal iyon salınımı ile etki göstermektedir.

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In-vitro assessment of oxidative stress generated by orthodontic archwires

Cited by 35 publications

References 28 publications

In vitro biocompatibility of nickel-titanium esthetic orthodontic archwires

In vitro biocompatibility of nickel-titanium esthetic orthodontic archwires

Influence of surface layer on mechanical and corrosion properties of nickel-titanium orthodontic wires

Ortodonti̇de Kullanilan Malzemeleri̇n Si̇totoksi̇si̇tesi̇ni̇n Değerlendi̇ri̇lmesi̇

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