In Vitro Assessment of Poly-iodinated Triglyceride Reconstituted Low-Density Lipoprotein

Hill, Melissa L.; Corbin, Ian R.; Levitin, R.; Cao, Weiguo; Mainprize, James G.; Yaffe, Martin J.; Zheng, Gang

doi:10.1016/j.acra.2010.06.006

Cited by 36 publications

(29 citation statements)

References 23 publications

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“…Hill and coworkers used 2-oleoylglycerol 1,3-bis(iodopanoate), a poly-iodinated triglyceride, to reconstitute the core of LDL. 31 Incubation of the resultant rLDL with HepG2 cells led to the enhancement in imaging contrast as compared to the control group in which excess LDL was used to block the endocytic pathway. In extending the labeling category of exogenous substances, Allijn and coworkers developed a micelle-translocation method to label LDL with a variety of contrast agents, including Au nanoparticles and lipophilic or amphiphilic fluorophores (Fig.…”

Section: Reconstituted Ldl For Contrast Enhancement and Therapymentioning

confidence: 98%

Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications

Zhu

Xia

2017

Chem. Soc. Rev.

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Low-density lipoprotein (LDL), one of the four major groups of lipoproteins for lipid transport in vivo, is emerging as an attractive carrier for the targeted delivery of theranostic agents. In contrast to the synthetic systems, LDL particles are intrinsically biocompatible and biodegradable, together with reduced immunogenicity and natural capabilities to target cancerous cells and to escape from the recognition and elimination by the reticuloendothelial system. Enticed by these attributes, a number of strategies have been developed for reconstituting LDL particles, including conjugation to the apolipoprotein, insertion into the phospholipid layer, and loading into the core. Here we present a tutorial review on the development of reconstituted LDL (rLDL) particles for theranostic applications. We start with a brief introduction to LDL and LDL receptor, as well as the advantages of using rLDL particles as a natural and versatile platform for the targeted delivery of theranostic agents. After a discussion of commonly used strategies for the reconstitution of LDL, we highlight the applications of rLDL particles in the staging of disease progression, treatment of lesioned tissues, and delivery of photosensitizers for photodynamic cancer therapy. We finish this review with a perspective on the remaining challenges and future directions.

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Section: Reconstituted Ldl For Contrast Enhancement and Therapymentioning

confidence: 98%

Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications

Zhu

Xia

2017

Chem. Soc. Rev.

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“…Differently sized AuNPs have been evaluated for micro CT for example, and some are under the consideration for approval for use in the clinic [301,302,303]. A low-density lipoprotein (LDL)-based iodinated nanoparticle targeting the LDL receptor (LDLR), expressed in PCa, for example, has also been evaluated for CT imaging [304,305,306], as well as polyvinyl pyrrolidone coated bismuth sulfide (Bi 2 S 3 ) based nanocrystals [307]. For tomosynthesis, the same general principle applies as described above for CT, namely that the contrast in an image could be increased approximately three times using AuNPs as compared to using the same amount of iodine-based contrast agent.…”

Section: Multimodal Imaging Options For Prostate and Breast Cancermentioning

confidence: 99%

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Elgqvist

2017

IJMS

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Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates. By using nanoparticles as vehicles carrying both diagnostic and therapeutic molecular entities, individualized targeted theranostic nanomedicine has emerged as a promising option to increase the sensitivity and the specificity during diagnosis, as well as the likelihood of survival or prolonged survival after therapy. This article presents and discusses important and promising different kinds of nanoparticles, as well as imaging and therapy options, suitable for theranostic applications. The presentation of different nanoparticles and theranostic applications is quite general, but there is a special focus on prostate cancer. Some references and aspects regarding breast cancer are however also presented and discussed. Finally, the prostate cancer case is presented in more detail regarding diagnosis, staging, recurrence, metastases, and treatment options available today, followed by possible ways to move forward applying theranostics for both prostate and breast cancer based on promising experiments performed until today.

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“…Nevertheless, reconstituted LDL contrast agents have been reported. For example, Hill et al synthesized iodinated triglycerides to label LDL to form a contrast agent for x-ray based imaging techniques such as CT.[140] Labeling was done via the Krieger method,[141] which involves lyophilization of LDL, extraction of the original triglyceride core, addition of the iodinated triglycerides in toluene, removal of the solvents and reconstitution of the LDL in buffer. CT imaging of solutions of this labeled LDL and of pellets of HepG2 cells that had been incubated with the labeled LDL demonstrated that this formulation could act as a CT contrast agent.…”

Section: Lipoprotein-based Contrast Agentsmentioning

confidence: 99%

Lipoproteins and lipoprotein mimetics for imaging and drug delivery

Thaxton

Rink

Naha

et al. 2016

Advanced Drug Delivery Reviews

121

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Lipoproteins are a set of natural nanoparticles whose main role is the transport of fats within the body. While much work has been done to develop synthetic nanocarriers to deliver drugs or contrast media, natural nanoparticles such as lipoproteins represent appealing alternatives. Lipoproteins are biocompatible, biodegradable, non-immunogenic and are naturally targeted to some disease sites. Lipoproteins can be modified to act as contrast agents in many ways, such as by insertion of gold cores to provide contrast for computed tomography. They can be loaded with drugs, nucleic acids, photosensitizers or boron to act as therapeutics. Attachment of ligands can re-route lipoproteins to new targets. These attributes render lipoproteins attractive and versatile delivery vehicles. In this review we will provide background on lipoproteins, then survey their roles as contrast agents, in drug and nucleic acid delivery, as well as in photodynamic therapy and boron neutron capture therapy.

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In Vitro Assessment of Poly-iodinated Triglyceride Reconstituted Low-Density Lipoprotein

Cited by 36 publications

References 23 publications

Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications

Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

Lipoproteins and lipoprotein mimetics for imaging and drug delivery

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