In Vitro Bioactivity and Antibacterial Effects of a Silver-Containing Mesoporous Bioactive Glass Film on the Surface of Titanium Implants

Abstract

Peri-implantitis is defined as a bacterial infection-induced inflammation and suppuration of soft and hard tissues surrounding a dental implant. If bacteria further invade the alveolar bone, they can easily cause bone loss and even lead to the early failure of a dental implant surgery. In the present study, an 80SiO2–15CaO–5P2O5 mesoporous bioactive glass film system containing 1, 5, and 10 mol% of silver was prepared on titanium implant discs (MBG–Ag–coated Ti) using sol-gel and spin coating methods. The wettability and adhesion strength of the films were evaluated using contact angle measurements and adhesion strength tests, respectively. The phase composition, chemical bonding, morphology, and oxidation states of the films were analyzed via X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS). In vitro bioactivity analysis of the films was performed by immersion in a simulated body fluid (SBF) for 24 h. Disk diffusion tests were performed on the early colonizing bacteria Aggregatibacter actinomycetemcomitans and Streptococcus mutans to evaluate the antibacterial ability of the films. A silver-containing mesoporous bioactive glass film with excellent biocompatibility and antibacterial properties was successfully prepared.

Advanced materials and technologies for oral diseases

“…Wang et al found that the MBG – Ag coating can convert the hydrophobicity of the titanium implant surface into hydrophilicity, and this mesoporous structure can also prolong the antibacterial time by controlling the release of Ag. May help prevent and treat early implant failure and peri-implantitis [ 218 ]. These results suggest that nanosilver coating is a promising material with antibacterial properties for implant abutments and prostheses to prevent peri-implantitis.…”

Antibacterial Adhesion Strategy for Dental Titanium Implant Surfaces: From Mechanisms to Application

“…To improve their performance, researchers have chosen to functionalize them further. Some studies have demonstrated that being loaded with antimicrobial peptides, antibiotics, bactericidal agents, or some metal ions can enhance their antibacterial properties [ 119 , 157 , 158 ]. Researchers previously grafted an antimicrobial peptide, Magainin I (Mag), to a titanium oxide surface [ 159 ].…”

Surface Modification and Functionalities for Titanium Dental Implants

“…The success rate of Ti dental implant surgery can reach over 90%, but there are still about 10% failures . The key that determines the success of Ti implants is the effective osseointegration. − In addition, improving the antibacterial properties of the implant and suppressing peri-implant inflammation are also important factors for the success of the surgery. − Osteogenesis requires osteoblasts to adhere and grow on the surface of the implant. − And the occurrence of inflammation is mostly related to bacterial adsorption and biofilm formation on the surface of implants. − All of the above processes are closely related to the surface conditions of Ti implants. However, during the Ti implant manufacturing process, if the overall material is changed to achieve good surface conditions, the overall performance of the implant may be seriously affected.…”