In vitro bioactivity and antibacterial capacity of 45S5 Bioglass®-based compositions containing alumina and strontium

Araujo, Mariana Silva de; Silva, A.C.; Cabal, Belén; Bartolomé, José F.; Mello-Castanho, Sonia Regina Homem de

doi:10.1016/j.jmrt.2021.04.053

Cited by 20 publications

(14 citation statements)

References 31 publications

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“…This was attributed to the HCA formed during SBF immersion. However, the HCA peaks detected in hybrids were slightly different to those of bioactive glasses (Ting et al, 2017;Araujo et al, 2021). It indicates that the HCA crystals formed on hybrids have slightly different preferred growth orientation to the HCA crystal formed on bioactive glasses.…”

Section: Dissolution In Sbfmentioning

confidence: 90%

Bioactive, Degradable and Tough Hybrids Through Calcium and Phosphate Incorporation

Tallia

Ting²,

Page³

et al. 2022

Front. Mater.

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We report the first inorganic/organic hybrids that show outstanding mechanical properties (withstanding cyclic loading) and bone bioactivity. This new hybrid material may fulfil the unmet clinical need for bioactive synthetic bone grafts that can withstand cyclic loading. A SiO2/PTHF/PCL-diCOOH sol-gel hybrid system, that combined inorganic and organic co-networks at the molecular level, previously demonstrated unprecedented synergy of properties, with excellent flexibility and promoted formation of articular cartilage matrix in vitro. Here, for the first time, calcium and phosphate ions were incorporated into the inorganic component of the hybrid network, to impart osteogenic properties. Calcium methoxyethoxide and triethyl phosphate were the calcium and phosphate precursors because they allow for incorporation into the silicate network at low temperature. The hybrid network was characterised with ATR-FTIR, XRD and solid-state Nuclear Magnetic Resonance, which proved calcium and phosphate incorporation and suggested the Ca2+ ions also interacted with PCL-diCOOH through ionic bonds. This resulted in an increased strength (17–64 MPa) and modulus of toughness (2.5–14 MPa) compared to the original SiO2/PTHF/PCL-diCOOH hybrid material (which showed strength of ∼3 MPa and modulus of toughness of ∼0.35 MPa), while also maintaining the ability to withstand cyclic loading. The presence of calcium and phosphates in the silicate network resulted in a more congruent dissolution of the inorganic and organic co-networks in TRIS buffer. This was shown by the presence of silicon, calcium and phosphate ions along with PCL in the TRIS buffer after 1 week, whereas Ca-free hybrids mainly released PCL with negligible Si dissolution. The presence of calcium and phosphates also enabled deposition of hydroxycarbonate apatite following immersion in simulated body fluid, which was not seen on Ca-free hybrid. All hybrids passed cell cytotoxicity tests and supported pre-osteoblast cell attachment. The phosphate-free hybrid showed the best mechanical behaviour and supported better cell attachment, spreading and potentially differentiation of cells. Therefore, the SiO2-CaO/PTHF/PCL-diCOOH hybrid represents a promising biomaterial for use in bone regeneration.

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Section: Dissolution In Sbfmentioning

confidence: 90%

Bioactive, Degradable and Tough Hybrids Through Calcium and Phosphate Incorporation

Tallia

Ting²,

Page³

et al. 2022

Front. Mater.

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“…In our study, the Mg discs displayed higher antibacterial activity than Mg‐Sc discs in S. aureus growth medium owing to their higher corrosion rate and pH values 6,13,38,61‐63 . To combat this reduction in antibacterial properties in Mg‐Sc, we added Sr to improve antibacterial properties of the alloy 64‐67 . Gao et al reported that the in vitro antibacterial tests on Mg‐Sr‐Ga alloy placed it on the top of the ranking list of germ‐killing ability.…”

Section: Discussionmentioning

confidence: 77%

“…Additionally, Baheiraei et al showed Sr incorporation on Gelatin‐bioglass scaffolds effectively enhanced antibacterial activities against both S. aureus and Escherichia coli 64 . Moghanian and Araujo also confirmed the Sr substituted bioglass exhibited antibacterial effect against methicillin‐resistant Staphylococcus aureus bacteria 65,66 …”

Section: Discussionmentioning

confidence: 97%

An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications

Aboutalebianaraki

Zeblisky

Sarker

et al. 2022

J Biomedical Materials Res

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The aim of this study was to develop a novel biodegradable magnesium (Mg) alloy for bone implant applications. We used scandium (Sc; 2 wt %) and strontium (Sr; 2 wt %) as alloying elements due to their high biocompatibility, antibacterial efficacy, osteogenesis, and protective effects against corrosion. In the present work, we also examined the effect of a heat treatment process on the properties of the Mg‐Sc‐Sr alloy. Alloys were manufactured using a metal casting process followed by heat treatment. The microstructure, corrosion, mechanical properties, antibacterial activity, and osteogenic activity of the alloy were assessed in vitro. The results showed that the incorporation of Sc and Sr elements controlled the corrosion, reduced the hydrogen generation, and enhanced mechanical properties. Furthermore, alloying with Sc and Sr demonstrated a significantly enhanced antibacterial activity and decreased biofilm formation compared to control Mg. Also, culturing Mg‐Sc‐Sr alloy with human bone marrow‐derived mesenchymal stromal cells showed a high degree of biocompatibility (>90% live cells) and a significant increase in osteoblastic differentiation in vitro shown by Alizarin red staining and alkaline phosphatase activity. Based on these results, the Mg‐Sc‐Sr alloy heat‐treated at 400°C displayed optimal mechanical properties, corrosion rate, antibacterial efficacy, and osteoinductivity. These characteristics make the Mg‐Sc‐Sr alloy a promising candidate for biodegradable orthopedic implants in the fixation of bone fractures such as bone plate‐screws or intramedullary nails.

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“…Zinc was also added into the bioglass structure due to its beneficial properties on bone formation in vitro and in vivo [ 157 , 158 , 159 ]. Raman spectra, EDX microscopy, and studies performed on cell culture revealed that the incorporation of Zn 2+ into the bioglass system is beneficial for cell attachment.…”

Section: Focus On Bioactive Glasses Bioglass ® 45s5mentioning

confidence: 99%

“…Moreover, the studied samples exhibited an antibacterial effect against E. coli strains. The combined effect of antibacterial activity and biocompatibility promotes bioactive glasses to be used for bone regeneration [ 157 ].…”

Section: Focus On Bioactive Glasses Bioglass ® 45s5mentioning

confidence: 99%

Current Development in Biomaterials—Hydroxyapatite and Bioglass for Applications in Biomedical Field: A Review

Filip

Surdu

Paduraru

et al. 2022

JFB

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Inorganic biomaterials, including different types of metals and ceramics are widely used in various fields due to their biocompatibility, bioactivity, and bioresorbable capacity. In recent years, biomaterials have been used in biomedical and biological applications. Calcium phosphate (CaPs) compounds are gaining importance in the field of biomaterials used as a standalone material or in more complex structures, especially for bone substitutes and drug delivery systems. The use of multiple dopants into the structure of CaPs compounds can significantly improve their in vivo and in vitro activity. Among the general information included in the Introduction section, in the first section of this review paper, the authors provided a background on the development of hydroxyapatite, methods of synthesis, and its applications. The advantages of using different ions and co-ions for substitution into the hydroxyapatite lattice and their influence on physicochemical, antibacterial, and biological properties of hydroxyapatite are also presented in this section of the review paper. Larry Hench’s 45S5 Bioglass®, commercially named 45S5, was the first bioactive glass that revealed a chemical bond with bone, highlighting the potential of this biomaterial to be widely used in biomedicine for bone regeneration. The second section of this article is focused on the development and current products based on 45S5 Bioglass®, covering the historical evolution, importance of the sintering method, hybrid bioglass composites, and applications. To overcome the limitations of the original biomaterials, studies were performed to combine hydroxyapatite and 45S5 Bioglass® into new composites used for their high bioactivity and improved properties. This particular type of combined hydroxyapatite/bioglass biomaterial is discussed in the last section of this review paper.

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In vitro bioactivity and antibacterial capacity of 45S5 Bioglass®-based compositions containing alumina and strontium

Cited by 20 publications

References 31 publications

Bioactive, Degradable and Tough Hybrids Through Calcium and Phosphate Incorporation

Bioactive, Degradable and Tough Hybrids Through Calcium and Phosphate Incorporation

An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications

Current Development in Biomaterials—Hydroxyapatite and Bioglass for Applications in Biomedical Field: A Review

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