2018
DOI: 10.1016/j.jmbbm.2018.03.016
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In-vitro biocompatibility, bioactivity, and mechanical strength of PMMA-PCL polymer containing fluorapatite and graphene oxide bone cements

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Cited by 94 publications
(62 citation statements)
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“…However, the poor bonding interactions between polymers and bioceramics have significantly affected the performance of their composites. To tackle this challenge, several groups have introduced GO into the polymer and bioceramic composites as an interface phase to enhance the interfacial bonding between polymers and bioceramics . On one hand, GO could interact with polymers through strong π‐π stacking interaction or Van Der Waals interaction via the nonpolar carbon sheet; on the other hand, the negatively charged oxygen‐containing functional groups could adsorb the positively charged Ca 2+ and then interact with bioceramics through electrostatic interaction.…”
Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning
confidence: 99%
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“…However, the poor bonding interactions between polymers and bioceramics have significantly affected the performance of their composites. To tackle this challenge, several groups have introduced GO into the polymer and bioceramic composites as an interface phase to enhance the interfacial bonding between polymers and bioceramics . On one hand, GO could interact with polymers through strong π‐π stacking interaction or Van Der Waals interaction via the nonpolar carbon sheet; on the other hand, the negatively charged oxygen‐containing functional groups could adsorb the positively charged Ca 2+ and then interact with bioceramics through electrostatic interaction.…”
Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning
confidence: 99%
“…Studies involving different types of polymers with calcium phosphates (CaPs), HA, as well as fluorapatite have been reported. With the introduction of GO, enhancement of mechanical strength, increase in hydrophilicity, and promotion in cell adhesion, proliferation, and osteogenic differentiation have been observed in these studies. For example, in Bi and co‐workers' study, their system of GO, CaPs and pluronic F127 realized a significant synergistic effect on accelerating hMSCs differentiation to osteoblast ( Figure A) .…”
Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning
confidence: 99%
“…This behavior revealed that the incorporation of the P(MMA-AA) into the cement could improve the cement-cell interfacial bioactivity and promote the cell adhesion on the cement. Since the hydrophilicity of the materials promoted the cell adhesion and biocompatibility of polymeric components, [31] the hydrophilicity of PMMA bone cement was modified by the P(MMA-AA) copolymer with the hydroxyl groups, which provided more attachment sites for cells, [32] subsequently contributing to the higher cell proliferation and cell adhesion on the EBC 5. In addition, the promoted surface wettability would affect cell adhesion on biomaterial, [33] and the increased surface energy also promoted cell adhesion and spreading.…”
Section: Cytotoxicity and Biocompatibilitymentioning
confidence: 99%
“…1,2 PMMAbased bone cements are vital materials for orthopedic applications such as artificial joint fixations and also as filler for bone defects. 6 These cements also experience low the mechanical properties, thus incorporation of bioceramics enhances both bioactivity and mechanical properties of the cements. 3 Therefore, numerous studies were carried out in order to enhance PMMA properties by mixing this polymer with other polymers.…”
Section: Introductionmentioning
confidence: 99%
“…In fact, PMMA-based cements with low bioactivity provide less osseointegration with periprosthetic bone. 6 These cements also experience low the mechanical properties, thus incorporation of bioceramics enhances both bioactivity and mechanical properties of the cements. It was reported 7 that blend polymer suffers from low bioactivity, hence the incorporation of bioceramics such calcium phosphates (Ca-P) and silicate-based ceramics into the polymer-based bone cements will enhance bioactivity which is favorable for bone-bonding ability.…”
Section: Introductionmentioning
confidence: 99%