In vitro biocompatibility of new bioactive lithia-silica glass-ceramics

Daguano, Juliana Kelmy Macário Barboza; Milesi, Mariana T.B.; Rodas, Andrea C.D.; Weber, Aline F.; Sarkis, J.E.S.; Hortellani, Marcos Antonio; Zanotto, Edgar Dutra

doi:10.1016/j.msec.2018.09.006

Cited by 41 publications

(31 citation statements)

References 39 publications

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“…An advantageous aspect of bioactive glass is its bioactivity and biocompatibility. Previous studies adopted the direct contact cell viability method to evaluate the biocompatibility of bioactive glass and showed a high cell survival rate [43,44]. As a very safe material and based on the merits stated above, a potential new application of bioactive glass is for dental caries prevention and remineralization of early caries lesions [45].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Bioactive Glass on Caries Management: A Review

2019

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This review investigates the mechanisms of bioactive glass on the management of dental caries. Four databases (PubMed, Web of Science, EMBASE (via Ovid), Medline (via Ovid)) were systematically searched using broad keywords and terms to identify the literature pertaining to the management of dental caries using “bioactive glass”. Titles and abstracts were scrutinized to determine the need for full-text screening. Data were extracted from the included articles regarding the mechanisms of bioactive glass on dental caries management, including the aspect of remineralizing effect on enamel and dentine caries, and antimicrobial effect on cariogenic bacteria. After removal of duplicates, 1992 articles were identified for screening of the titles and abstracts. The full texts of 49 publications were scrutinized and 23 were finally included in this review. Four articles focused on the antimicrobial effect of bioactive glass. Twelve papers discussed the effect of bioactive glass on demineralized enamel, while 9 articles investigated the effect of bioactive glass on demineralized dentine. In conclusion, bioactive glass can remineralize caries and form apatite on the surface of enamel and dentine. In addition, bioactive glass has an antibacterial effect on cariogenic bacteria of which may help to prevent and arrest dental caries.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of Bioactive Glass on Caries Management: A Review

2019

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“…Numerous studies have also demonstrated that surfaces with high surface free energy foster microbial adherence in vitro and in vivo [35][36][37][38]. In addition, bacteria with high cell surface free energy appear to adhere preferentially to surfaces with high surface free energy.…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial adhesion to a substrate and the initial biofilm composition is also related to surface hydrophobicity, and communication between existing microorganisms [28,37,38]. Although the literature shows that bacteria adhere better to hydrophobic surfaces, biofilm formation depends not only on the surface topography but also on the bacteria species involved.…”

Section: Discussionmentioning

confidence: 99%

Anti-Bacterial Properties and Biocompatibility of Novel SiC Coating for Dental Ceramic

Camargo

Mohiuddeen

Fares

et al. 2020

JFB

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A 200 nm plasma-enhanced chemical vapor-deposited SiC was used as a coating on dental ceramics to improve anti-bacterial properties for the applications of dental prosthesis. A thin SiO2 (20 nm) in the same system was deposited first, prior to SiC deposition, to improve the adhesion between SiC to dental ceramic. Silane and methane were the precursors for SiC deposition, and the SiO2 deposition employed silane and nitrous oxide as the precursors. SiC antimicrobial activity was evaluated on the proliferation of biofilm, Streptococcus sanguinis, and Streptococcus mutans on SiC-coated and uncoated dental ceramics for 24 h. The ceramic coating with SiC exhibited a biofilm coverage of 16.9%, whereas uncoated samples demonstrated a significantly higher biofilm coverage of 91.8%, measured with fluorescence and scanning electron microscopic images. The cytotoxicity of the SiC coating was evaluated using human periodontal ligament fibroblasts (HPdLF) by CellTiter-BlueCell viability assay. After 24 h of HPdLF cultivation, no obvious cytotoxicity was observed on the SiC coating and control group; both sets of samples exhibited similar cell adhesion and proliferation. SiC coating on a ceramic demonstrated antimicrobial activity without inducing cytotoxic effects.

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“…The orientation, shape, and distribution of crystal sizes, homogeneity, and the proportion of the glassy matrix and crystalline phase control the exural strength and fracture toughness of the glass-ceramic materials [2,28]. The surface morphology showed for all groups that the crystals have lath-shaped [6,29] and an interlocked microstructure that is an important characteristic for the mechanical performance of the material [3,10,11,23,30] because it allows during the de ection of the crack that the path that it would have to travel increases and consequently consumes more energy [3,10,11].…”

Section: Discussionmentioning

confidence: 99%

“…It is considered that the greater the aesthetics of ceramic materials, the lower their fracture resistance, since they present a greater glass phase and a lower crystalline phase, as is the case of glass-ceramics that are considered a special group of materials and have their microstructure composed of one or more crystalline phases embedded in glass matrix [3], with crystallinity ranging from 30-70% and crystals with needle morphology with dimensions from 3 µm to 6 µm [3,9]. This con guration results in a microstructure with lithium disilicate crystals interlocked lath-shaped that promote an increase in the exural resistance of these materials and result in the limitation of the propagation of the crack, because the conformation of the crystals make that, during the de ection of the crack, the path that the crack would have to go through increases [3,[9][10][11] and, consequently, consumes more energy.…”

Section: Introductionmentioning

confidence: 99%

Nucleation Heat Treatment on the Crystalline Fraction and Crystal Morphology of Lamav Cad Lithium Disilicate

Vallerini

Villas-Bôas

Pinelli

2020

Preprint

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Thus, this study aimed to evaluate the influence of different nucleation heat treatments on the crystalline fraction and crystal morphology of the LS2 LaMaV CAD. Discs (12 mm diameter x 1.2 mm thickness) of LS2 LaMaV CAD and IPS e.max CAD (C, control group, n=3) were made. LS2 LaMaV CAD discs were annealed at 380oC/2h followed by different nucleation heat treatments in which time and temperature were varied composing 4 groups (n=3): T1 (1h30/500oC), T2 (3h/500oC), T3 (6h/500oC) and T4 (6h/480oC). Scanning Electron Microscopy images were obtained to characterize the microstructure and to quantify the crystalline fraction using the ImageJ software. X-ray diffraction with Rietveld refinement was performed. ANOVA one-way with Tukey post-hoc test (a = 0.05) was used to analyze the ImageJ images and the Rietveld refinements for X-ray diffraction data. X-ray diffraction analysis showed peaks of approximately 86% of lithium disilicate for all groups. The morphology of crystals was in lath-shaped and homogeneous format for all groups; the group that most resembled the C group was T1. The crystalline fraction (%) was: C = 59.33 ± 0.47, T1 = 61.63 ± 0.61, T2 = 61.07 ± 1.09, T3 = 56.39 ± 0.32, and T4 = 57.48 ± 0.90, all the groups were statistically different to the C group. It was concluded that the nucleation temperature influenced the size and quantity of the crystals of lithium disilicate; treatment that showed the best result was that that received nucleation treatment for 1 hour and 30 minutes at 500ºC.

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In vitro biocompatibility of new bioactive lithia-silica glass-ceramics

Cited by 41 publications

References 39 publications

Mechanisms of Bioactive Glass on Caries Management: A Review

Mechanisms of Bioactive Glass on Caries Management: A Review

Anti-Bacterial Properties and Biocompatibility of Novel SiC Coating for Dental Ceramic

Nucleation Heat Treatment on the Crystalline Fraction and Crystal Morphology of Lamav Cad Lithium Disilicate

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